House musk shrew (Suncus murinus, order: Insectivora) as a new model animal for motilin study.

abstract：:Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...

journal_title：Peptides

authors： Zhuo JL,Li XC

更新日期：2011-07-01 00:00:00

abstract：:The ability to measure changes in brain levels of corticotropin-releasing factor (CRF) is an important step toward understanding the role of this neuropeptide in mood states. Here, we report for the first time that the protein (Western) immunoblot assay can be used to detect and quantify CRF (4.7 kDa) from the rat bra...

journal_title：Peptides

authors： Meloni EG,Jackson AV,Cohen BM,Carlezon WA Jr

更新日期：2005-11-01 00:00:00

abstract：:We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...

journal_title：Peptides

authors： Wanke IE,Huang M,Rorstad OP

更新日期：1990-11-01 00:00:00

abstract：:It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...

journal_title：Peptides

authors： Ku YH,Chang YZ

更新日期：2001-09-01 00:00:00

abstract：:The very first step in the study of the endocrine control of insect molting was taken in 1922. Stefan Kopec characterized a factor in the brain of the gypsy moth, Lymantria dispar which appeared to be essential for metamorphosis. This factor was later identified as the neuropeptide prothoracicotropic hormone (PTTH), t...

journal_title：Peptides

authors： Marchal E,Vandersmissen HP,Badisco L,Van de Velde S,Verlinden H,Iga M,Van Wielendaele P,Huybrechts R,Simonet G,Smagghe G,Vanden Broeck J

更新日期：2010-03-01 00:00:00

abstract：:We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...

journal_title：Peptides

authors： Kanduc D,Lucchese A,Mittelman A

更新日期：2001-12-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) has been implicated in the itch-scratch cycle. We investigated if this gut-brain-skin peptide plays a role in the compulsive, hindleg scratching of the neck of mice by 5'-guanidinonaltrindole (GNTI), the kappa opioid receptor antagonist, and in the antipruritic activity of nalfurafine, ...

journal_title：Peptides

authors： Inan S,Dun NJ,Cowan A

更新日期：2011-02-01 00:00:00

abstract：:The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...

journal_title：Peptides

authors： Lalani S,Gew LT,Poh CL

更新日期：2020-11-07 00:00:00

abstract：:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...

journal_title：Peptides

authors： Britz FC,Deitmer JW

更新日期：2002-12-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...

journal_title：Peptides

authors： Botz B,Imreh A,Sándor K,Elekes K,Szolcsányi J,Reglődi D,Quinn JP,Stewart J,Zimmer A,Hashimoto H,Helyes Z

更新日期：2013-05-01 00:00:00

abstract：:A linear peptide containing two reduced cysteine residues can be rapidly converted to its oxidized cyclic form containing an intramolecular disulfide bond by adding an excess of 2,2'-bispyridyl disulfide (2,2'-dipyridyl disulfide or 2,2'-dithiodipyridine) to conventional buffer solutions. The reactants and products ar...

journal_title：Peptides

authors： Maruyama K,Nagasawa H,Suzuki A

更新日期：1999-01-01 00:00:00

abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...

journal_title：Peptides

authors： Micanovic R,Kruggel W,Ray P,Lewis RV

更新日期：1984-09-01 00:00:00

abstract：:We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...

journal_title：Peptides

authors： Ochiai T,Chijiiwa Y,Motomura Y,Yasuda O,Harada N,Nawata H

更新日期：2001-06-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...

journal_title：Peptides

authors： Devemy E,Blaschuk OW

更新日期：2008-11-01 00:00:00

abstract：:Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...

journal_title：Peptides

authors： Disa J,Floyd LE,Edwards RM,Douglas SA,Aiyar NV

更新日期：2006-06-01 00:00:00

abstract：:In this Festschrift, I discuss the career and guiding principles to which Abba J. Kastin has adhered during the last 20 years we worked together. I briefly describe the history of our joint laboratory group, the context of studies of peptide permeation across the blood-brain barrier (BBB), and newer developments in th...

journal_title：Peptides

authors： Pan W

更新日期：2015-10-01 00:00:00

abstract：:Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperp...

journal_title：Peptides

authors： Polidori C,de Caro G,Massi M

更新日期：2000-07-01 00:00:00

abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...

journal_title：Peptides

authors： Hornby PJ,Piekut DT

更新日期：1989-11-01 00:00:00

abstract：:More than 40 peptides belonging to the -Y/FXFGL-NH(2) allatostatin superfamily have been isolated and identified from the central nervous system (CNS) of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea). The peptides can be arranged in seven sub-groups according to the variable post-tyrosyl residue represented ...

journal_title：Peptides

authors： Duve H,Johnsen AH,Scott AG,Thorpe A

更新日期：2002-06-01 00:00:00

abstract：:Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

journal_title：Peptides

authors： Dees WL,Kozlowski GP

更新日期：1984-01-01 00:00:00

abstract：:CR 1409, a glutaramic acid derivative with competitive cholecystokinin-antagonistic activity, was administered IP and evaluated in comparison with proglumide (the model CCK-receptor antagonist), gabexate (protease inhibitor) and PGE2 (cytoprotective) on two different models of experimental pancreatitis. Acute pancreat...

journal_title：Peptides

authors： Makovec F,Bani M,Cereda R,Chistè R,Revel L,Rovati LC,Setnikar I,Rovati LA

更新日期：1986-11-01 00:00:00

abstract：:Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...

journal_title：Peptides

authors： Pinheiro-Júnior EL,Boldrini-França J,de Campos Araújo LMP,Santos-Filho NA,Bendhack LM,Cilli EM,Arantes EC

更新日期：2018-04-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Neuromedin B (NMB), which was originally isolated from porcine spinal cord, is a mammalian bombesin-related peptide that exerts various physiological effects. Previously, we observed expression of NMB in rib cartilage from chicken. Here, we report the initial attempt to elucidate the role of NMB in cartilage. We used ...

journal_title：Peptides

authors： Saito H,Ikeda R,Inoue K,Nagata S,Kitamura K,Minamino N,Kangawa K,Miyata A

更新日期：2012-08-01 00:00:00

abstract：:Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin n...

journal_title：Peptides

authors： Corwin RL,Corp ES,Gibbs J,Smith GP

更新日期：1992-11-01 00:00:00

abstract：:Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...

journal_title：Peptides

authors： Hikosaka T,Tsuruda T,Nagata S,Kuwasako K,Tsuchiya K,Hoshiko S,Inatsu H,Chijiiwa K,Kitamura K

更新日期：2011-09-01 00:00:00

abstract：:Cocaine- and amphetamine regulated transcript (CART) is a recently discovered anorexigenic peptide, widely expressed in the central nervous system. Included among presumed hypothalamic mediated functions of CART are inhibition of food intake, stimulation of energy expenditure and regulation of hypothalamic-pituitary a...

journal_title：Peptides

authors： Fekete C,Lechan RM

更新日期：2006-08-01 00:00:00

abstract：:The purpose of this work was to determine the mechanism of the antisecretory effect of peptide YY in the rat colon and whether this effect is physiological. In this prospect, doses of exogenous peptide YY producing physiological and supraphysiological plasma levels were intravenously infused in rats provided with colo...

journal_title：Peptides

authors： Chariot J,Tsocas A,Souli A,Presset O,Rozé C

更新日期：2000-01-01 00:00:00