Abstract:
:Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then examined the immunohistochemical localization of BNP in the monkey hypothalamus. Japanese and cynomologus monkey prepro-BNP consisted of 132 amino acid residues with biologically active C-terminal 32 amino acids. Comparisons of deduced amino acid sequences among different species revealed high homology between monkey and human (91% in prerpro-BNP and 97% in the mature region). Immunohistochemical examination showed that BNP immunoreactive dots were observed in the paraventricular, periventricular, and supraoptic nuclei of the monkey hypothalamus. The present result suggests the central role of BNP in the neuroendocrine system in the hypothalamus.
journal_name
Peptidesjournal_title
Peptidesauthors
Abdelalim EM,Takada T,Torii R,Tooyama Idoi
10.1016/j.peptides.2006.01.001subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1886-93issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00005-2journal_volume
27pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remain...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2015.04.009
更新日期:2015-07-01 00:00:00
abstract::Peptic digestion of bovine hemoglobin at low degree of hydrolysis yields an intermediate peptide fraction exhibiting antibacterial activity against Micrococcus luteus A270, Listeria innocua, Escherichia coli and Salmonella enteritidis after separation by reversed-phase HPLC. From this fraction a pure peptide was isola...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.12.008
更新日期:2005-05-01 00:00:00
abstract::We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.05.003
更新日期:2017-07-01 00:00:00
abstract::We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.010
更新日期:2006-12-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.007
更新日期:2013-04-01 00:00:00
abstract::Angiotensin IV (Ang IV) is formed by aminopeptidase N from Ang III by removing the first N-terminal amino acid. Previously, we reported that Ang III has some cardioprotective effects against global ischemia in Langendorff heart. However, it is not clear whether Ang IV has cardioprotective effects. The aim of the prese...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.017
更新日期:2016-05-01 00:00:00
abstract::Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic functio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90098-p
更新日期:1990-03-01 00:00:00
abstract::We examined the expressions of the prepro-orexin gene in the lateral hypothalamic area (LHA), the genes of the neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the arcuate nucleus (ARC), the orexin type 1 receptor (OX1R) gene in the ventromedial hypothalamic nucleus (VMH) and the orexin type 2 receptor (OX2R) ge...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00111-0
更新日期:2002-09-01 00:00:00
abstract::Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02003-f
更新日期:1995-01-01 00:00:00
abstract::Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90006-q
更新日期:1990-09-01 00:00:00
abstract::Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.12.017
更新日期:2004-02-01 00:00:00
abstract::Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170369
更新日期:2020-09-01 00:00:00
abstract::Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA). In this study, we investigated the effect of carnosine treatment on TAA-induced oxidative stress and hepatotoxicity. Rats were injected in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.11.008
更新日期:2008-03-01 00:00:00
abstract::By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90090-1
更新日期:1984-05-01 00:00:00
abstract::Interdigestive migrating contractions (IMC) were analyzed for their occurrence interval, duration, migrating velocity, and frequently in long term records obtained by means of chronically implanted force transducers in the main stomach and the extrinsically denervated fundic pouches or in the intact jejunum and the ex...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90035-8
更新日期:1981-01-01 00:00:00
abstract::Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00461-2
更新日期:2001-08-01 00:00:00
abstract::There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00131-4
更新日期:1998-01-01 00:00:00
abstract::Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00569-1
更新日期:2001-12-01 00:00:00
abstract::Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00139-0
更新日期:2002-10-01 00:00:00
abstract::Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.08.015
更新日期:2008-12-01 00:00:00
abstract::Combined modulation of peptide hormone receptors including, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established benefits for the treatment of diabetes. The present study has assessed the biological actions and therapeutic efficacy of a novel exendin-4/xenin-8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.10.015
更新日期:2018-02-01 00:00:00
abstract::The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.034
更新日期:2008-02-01 00:00:00
abstract::Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.06.014
更新日期:2007-01-01 00:00:00
abstract::To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(95)00024-e
更新日期:1995-01-01 00:00:00
abstract::High affinity 125I-angiotensin II (Ang II) binding sites were characterized in the canine pancreas. Total binding increased with protein concentration and equilibrium was reached within 60-90 min at 22 degrees C. Specific binding was saturable and averaged 70% of total. Scatchard analysis of binding yielded a KD of 0....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90114-i
更新日期:1992-03-01 00:00:00
abstract::The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(88)90098-8
更新日期:1988-09-01 00:00:00
abstract::STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned S...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.015
更新日期:2005-01-01 00:00:00
abstract::The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.11.007
更新日期:2011-02-01 00:00:00
abstract::Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.014
更新日期:2012-02-01 00:00:00
abstract::We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.02.003
更新日期:2005-07-01 00:00:00