Abstract：
:The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantification of angiotensin II (ANG II) receptors and angiotensin converting enzyme (ACE) binding sites using quantitative autoradiography. In both neonatal and adult animals of either strain, ANG II receptors were of AT1 subtype. In all kidney areas of 1-week-old rats. ANG II receptor density was higher in SHR than WKY. Binding density increased with age in WKY rats; thus, in the glomeruli and the outer stripe of the outer medulla of 12-week-old WKY, binding was significantly higher than that present in age-matched SHR. [125I]351A binding to ACE was highest in the outer medulla and not detectable in glomeruli. In 1-week-old rats, binding to ACE was higher in WKY than in SHR strain. No differences in ACE binding were found between adult SHR and WKY rats, with the exception of the inner stripe of the outer medulla, where no binding was detected in SHR. Our results support the hypothesis that the RAS in kidney is developmentally regulated and is involved in the development and maintenance of genetic hypertension in SHR.
journal_name
Peptidesjournal_title
Peptidesauthors
Correa FM,Viswanathan M,Ciuffo GM,Tsutsumi K,Saavedra JMdoi
10.1016/0196-9781(94)00150-5subject
Has Abstractpub_date
1995-01-01 00:00:00pages
19-24issue
1eissn
0196-9781issn
1873-5169pii
0196978194001505journal_volume
16pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90175-1
更新日期：1988-05-01 00:00:00
abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90145-9
更新日期：1989-05-01 00:00:00
abstract：:Pinealectomized (PX) and sham animals were administered either AVT (1 ng/kg) or vehicle (1 ml H20). Boxing-kicking-biting episodes were significantly reduced by administration of AVT, F(1,21) = 8.09, p less than 0.009. Crawling under behavior was increased in PXH20 animals (p less than 0.05). Non-aggressive rearing wa...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90179-7
更新日期：1984-11-01 00:00:00
abstract：:Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00035-6
更新日期：1996-01-01 00:00:00
abstract：:Nesfatin-1 is well established to reduce food intake upon brain injection in rats, while in mice its anorexigenic action and brain expression are largely unexplored. We characterized the influence of intracerebroventricular (icv) and peripheral (intraperitoneal, ip, subcutaneous, sc) injection of nesfatin-1 on dark ph...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.09.027
更新日期：2011-01-01 00:00:00
abstract：:We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(81)90050-4
更新日期：1981-01-01 00:00:00
abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90014-3
更新日期：1987-05-01 00:00:00
abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90105-0
更新日期：1984-09-01 00:00:00
abstract：:To further characterize the structure and function of calcitonin gene-related peptide (CGRP) related peptides in fish, we have cloned cDNA sequences for CGRP, amylin, adrenomedullin (AM) and adrenomedullin-2/intermedin (IMD) in goldfish (Carassius auratus) and examined their tissue distribution. CGRP, amylin, AM and I...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.04.013
更新日期：2008-09-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.10.022
更新日期：2008-01-01 00:00:00
abstract：:Ghrelin is a 28 amino acid peptide, primarily produced by the oxyntic mucosa X/A like neuroendocrine cells in the stomach. It is also found in the small intestine, hypothalamus, pituitary gland, pancreas, heart, adipose tissue, and immune system. In gastrointestinal neuroendocrine tumors (NETs) ghrelin release has bee...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2011.10.006
更新日期：2011-11-01 00:00:00
abstract：:Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90019-0
更新日期：1983-09-01 00:00:00
abstract：:VIP was given intravenously over 1 min at the doses 0.1 and 0.2 micrograms X kg X min-1 to twenty-one anesthetized patients undergoing abdominal surgery. Intra-arterial blood pressure was monitored and various blood flows were measured simultaneously by electromagnetic technique. Following VIP, intra-arterial blood pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90227-4
更新日期：1984-03-01 00:00:00
abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90051-2
更新日期：1984-01-01 00:00:00
abstract：:The aims of these studies were to determine the precise molecular nature of immunoreactive (IR-) vasopressin (AVP) in the ovine hypothalamo-pituitary axis and to examine a possible role for glucocorticoids in regulating both AVP processing and levels in this axis. The IR-AVP in extracts of paraventricular nucleus, med...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90119-2
更新日期：1993-07-01 00:00:00
abstract：:Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.07.030
更新日期：2012-10-01 00:00:00
abstract：:CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170309
更新日期：2020-06-01 00:00:00
abstract：:In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00108-4
更新日期：1999-01-01 00:00:00
abstract：:MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00043-0
更新日期：1997-01-01 00:00:00
abstract：:To evaluate the effects of exogenous ghrelin or obestatin on intestinal injury and accompanying pulmonary injury, intestinal ischemia-reperfusion (I/R) was induced in rats by obstructing the superior mesenteric artery for 60min, whereas laparotomy was performed in the sham group. At the beginning of the 90-min reperfu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.04.014
更新日期：2015-09-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.09.005
更新日期：2008-12-01 00:00:00
abstract：:A 20-kDa protein with substantial N-terminal sequence homology to thaumatin-like proteins was isolated from ripe fruits of the emperor banana, Musa basjoo cv. 'emperor banana'. The isolation procedure entailed (NH(4))(2)SO(4) precipitation, ion exchange chromatography on DEAE-cellulose, and affinity chromatography on ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.01.005
更新日期：2007-04-01 00:00:00
abstract：:Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.09.014
更新日期：2006-04-01 00:00:00
abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.03.009
更新日期：2011-06-01 00:00:00
abstract：:Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...
journal_title：Peptides
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.peptides.2019.170117
更新日期：2019-09-01 00:00:00
abstract：:Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY signi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00345-x
更新日期：2001-03-01 00:00:00
abstract：:The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.12.015
更新日期：2008-05-01 00:00:00
abstract：:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00378-8
更新日期：2001-02-01 00:00:00
abstract：:Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membran...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2013.10.021
更新日期：2014-01-01 00:00:00
abstract：:Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.07.004
更新日期：2014-09-01 00:00:00
