Ghrelin in neuroendocrine tumors.

abstract：:NLP-12a and b have been identified as cholecystokinin/sulfakinin-like neuropeptides in the free-living nematode Caenorhabditis elegans. They are suggested to play an important role in the regulation of digestive enzyme secretion and fat storage. This study reports on the identification and characterization of an NLP-1...

journal_title：Peptides

authors： Peeters L,Janssen T,De Haes W,Beets I,Meelkop E,Grant W,Schoofs L

更新日期：2012-03-01 00:00:00

abstract：:The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...

journal_title：Peptides

authors： Aguilar AJ,Conde-Sieira M,López-Patiño MA,Míguez JM,Soengas JL

更新日期：2011-02-01 00:00:00

abstract：:Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...

journal_title：Peptides

authors： Ruohonen ST,Abe K,Kero M,Toukola L,Ruohonen S,Röyttä M,Koulu M,Pesonen U,Zukowska Z,Savontaus E

更新日期：2009-04-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) has a similar structure to that of vasoactive intestinal peptide (VIP) and both the polypeptides belong to the same molecular group, the secretin-glucagon superfamily. PACAP and VIP have possible potency as hypothalamic factors mediating the release of pituita...

journal_title：Peptides

authors： Matsuda K,Maruyama K,Nakamachi T,Miura T,Uchiyama M,Shioda S

更新日期：2005-09-01 00:00:00

abstract：:Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...

journal_title：Peptides

authors： Duque HM,Mourão CBF,Tibery DV,Barbosa EA,Campos LA,Schwartz EF

更新日期：2017-09-01 00:00:00

abstract：:We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...

journal_title：Peptides

authors： Zhu YX,Höllt V,Loh H

更新日期：1983-11-01 00:00:00

abstract：:Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...

journal_title：Peptides

authors： Simonet G,Claeys I,Van Soest S,Breugelmans B,Franssens V,De Loof A,Vanden Broeck J

更新日期：2004-06-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...

journal_title：Peptides

authors： Zhang S,Guo H,Shi F,Wang H,Li L,Jiao X,Wang Y,Yu H

更新日期：2012-02-01 00:00:00

abstract：:Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...

journal_title：Peptides

authors： Wang M,Rong M,Xiao Y,Liang S

更新日期：2012-03-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs are positively charged, mucins negatively. It was the aim of the study to test whether these opposite charges result in interactions between AMPs and mucins. We measur...

journal_title：Peptides

authors： Felgentreff K,Beisswenger C,Griese M,Gulder T,Bringmann G,Bals R

更新日期：2006-12-01 00:00:00

abstract：:Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...

journal_title：Peptides

authors： Lin C,Wang N,Shen ZP,Zhao ZY

更新日期：2013-04-01 00:00:00

abstract：:Urotensin II (UII), which was originally isolated from the teleost urophysis, was identified as an endogenous ligand for orphan G protein-coupled receptor 14 (GPR14). The structure of mammalian UII was confirmed by isolation from spinal cord in porcine, or was easily predicted from the sequence of prepro-UII in human....

journal_title：Peptides

authors： Sugo T,Mori M

更新日期：2008-05-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:Diadenosine polyphosphates (APnAs) are endogenous compounds and exert diverse cardiovascular functions. However, the effects of APnAs on atrial ANP release and contractility have not been studied. In this study, the effects of diadenosine tetraphosphate (AP4A) on atrial ANP release and contractility, and their mechani...

journal_title：Peptides

authors： Yuan K,Cao C,Bai GY,Kim SZ,Kim SH

更新日期：2007-07-01 00:00:00

abstract：:Urotensin II (UII), first identified from goby urophysis, is a potent vasoactive peptide hormone and an endogenous ligand for an orphan G protein-coupled receptor GPR14, now named urotensin II receptor (UT-R). In addition to its vascular actions, UII has been shown to have mitogenic effects on tumor growth and some re...

journal_title：Peptides

authors： Morimoto R,Satoh F,Murakami O,Totsune K,Arai Y,Suzuki T,Sasano H,Ito S,Takahashi K

更新日期：2008-05-01 00:00:00

abstract：:On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...

journal_title：Peptides

authors： Mahjoubi-Boubaker B,Crest M,Khalifa RB,El Ayeb M,Kharrat R

更新日期：2004-04-01 00:00:00

abstract：:Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...

journal_title：Peptides

authors： Jönsson M,Norrgård O,Forsgren S

更新日期：2005-05-01 00:00:00

abstract：:Orexin is one of the orexigenic neuropeptides in the hypothalamus. Orexin neurons in the lateral hypothalamus (LH) project into the cerebral cortex and hippocampus in which the receptors are distributed in high concentrations. Therefore, to elucidate the actions of orexin in the cerebral cortex, we examined its effect...

journal_title：Peptides

authors： Yamada N,Katsuura G,Tatsuno I,Asaki T,Kawahara S,Ebihara K,Saito Y,Nakao K

更新日期：2008-09-01 00:00:00

abstract：:Incorporation of N-succinimidyl-3(4-hydroxyphenyl) propionate (Bolton-Hunter reagent) or its 125I-labeled derivative into peptides can be selectively directed towards either alpha- or epsilon-amine functions by modifying the pH of the reaction. Acylation of alpha-amino groups is favored at pH 6.5 whereas epsilon-amino...

journal_title：Peptides

authors： Gaudriault G,Vincent JP

更新日期：1992-11-01 00:00:00

abstract：:The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta op...

journal_title：Peptides

authors： Stanojević S,Radulović J,Kovacević-Jovanović V,Vujić V,Dimitrijević M

更新日期：2002-09-01 00:00:00

abstract：:In vitro pepsin treatment of plasma proteins generates biologically active peptides such as enkephalin-related peptides. These peptides were characterized using chromatographic techniques along with a radioimmunoassay procedure involving the use of Leu-enkephalin and Met-enkephalin antisera. Serum albumin is the only ...

journal_title：Peptides

authors： Garreau I,Pejoan C,Bressollier P,Verneuil B,Cucumel K,Cupo A

更新日期：1994-01-01 00:00:00

abstract：:Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...

journal_title：Peptides

authors： Shi JB,Guo ZF,Zheng X,Wang ZB,Ma YJ

更新日期：2012-12-01 00:00:00

abstract：:The cervical sympathetic trunk-submandibular gland neuroendocrine axis plays an integral role in physiological adaptations and contributes to the maintenance of systemic homeostasis, particularly under the 'stress conditions' seen with tissue damage, inflammation, and aggressive behavior. The variety of polypeptides, ...

journal_title：Peptides

authors： Rougeot C,Rosinski-Chupin I,Mathison R,Rougeon F

更新日期：2000-03-01 00:00:00

abstract：:Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...

journal_title：Peptides

authors： Wewer Albrechtsen NJ

更新日期：2018-02-01 00:00:00

abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...

journal_title：Peptides

authors： Katsoulis S,Clemens A,Schwörer H,Creutzfeldt W,Schmidt WE

更新日期：1993-05-01 00:00:00

abstract：:Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The concentration of mature kisspeptins may not directly correlate with Kiss1 mRNA levels, because mRNA translation and...

journal_title：Peptides

authors： Overgaard A,Tena-Sempere M,Franceschini I,Desroziers E,Simonneaux V,Mikkelsen JD

更新日期：2013-07-01 00:00:00

abstract：:Neuropeptide S (NPS) produces several biological actions by activating a formerly orphan GPCR, now named NPS receptor (NPSR). It has been previously demonstrated that NPS stimulates murine leukocyte chemotaxis in vitro. In the present study we investigated the ability of NPS, in comparison with the proinflammatory pep...

journal_title：Peptides

authors： Filaferro M,Novi C,Ruggieri V,Genedani S,Alboni S,Malagoli D,Caló G,Guerrini R,Vitale G

更新日期：2013-01-01 00:00:00

abstract：:Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...

journal_title：Peptides

authors： Valdes-Gonzalez T,Inagawa J,Ido T

更新日期：2001-07-01 00:00:00

abstract：:VIP was given intravenously over 1 min at the doses 0.1 and 0.2 micrograms X kg X min-1 to twenty-one anesthetized patients undergoing abdominal surgery. Intra-arterial blood pressure was monitored and various blood flows were measured simultaneously by electromagnetic technique. Following VIP, intra-arterial blood pr...

journal_title：Peptides

authors： Thulin L,Nyberg B,Tyden G,Sonnenfeld T

更新日期：1984-03-01 00:00:00