Abstract:
:Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 126 healthy children and 126 children with acute severe TBI were measured by enzyme-linked immunosorbent assay. Twenty-one patients (16.7%) died and 38 patients (30.2%) had an unfavorable outcome (Glasgow Outcome Scale score of 1-3) at 6 months. Plasma copeptin level was obviously higher in patients than in healthy children (46.2±20.8 pmol/L vs. 9.6±3.0 pmol/L, P<0.001). Plasma copeptin level was identified as an independent predictor for 6-month mortality [odds ratio (OR) 1.261, 95% confidence interval (CI) 1.112-1.538, P=0.005] and unfavorable outcome (OR 1.313, 95% CI 1.146-1.659, P=0.003). The predictive value of copeptin was similar to that of Glasgow Coma Scale (GCS) score for 6-month mortality [area under curve (AUC) 0.832, 95% CI 0.755-0.892 vs. AUC 0.873, 95% CI 0.802-0.926, P=0.412] and unfavorable outcome (AUC 0.863, 95% CI 0.790-0.918 vs. AUC 0.885, 95% CI 0.816-0.935, P=0.596). Copeptin improved the AUC of GCS score for 6-month unfavorable outcome (AUC 0.929, 95% CI 0.869-0.967, P=0.013), but not for 6-month mortality (AUC 0.887, 95% CI 0.818-0.936, P=0.600). Thus, plasma copeptin level represents a novel biomarker for predicting 6-month clinical outcome in children with TBI.
journal_name
Peptidesjournal_title
Peptidesauthors
Lin C,Wang N,Shen ZP,Zhao ZYdoi
10.1016/j.peptides.2013.01.015subject
Has Abstractpub_date
2013-04-01 00:00:00pages
43-7eissn
0196-9781issn
1873-5169pii
S0196-9781(13)00034-Xjournal_volume
42pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90052-3
更新日期:1982-03-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) immunoreactive material has been found in extracts of the intestine, however, the structure of intestinal CGRP is not known. Analytical reverse phase HPLC and ion-exchange FPLC revealed one predominant immunoreactive CGRP peak in rabbit intestinal extracts. This material was puri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90014-g
更新日期:1991-03-01 00:00:00
abstract::Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00432-6
更新日期:2001-07-01 00:00:00
abstract::Neuropeptide Y (NPY) receptor binding sites have been characterized in rat brain using both membrane preparations and receptor autoradiography. Radiolabelled NPY binds with high affinity and specificity to an apparent single class of sites in rat brain membrane preparations. The ligand selectivity pattern reveals stro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90061-6
更新日期:1986-01-01 00:00:00
abstract::The interaction of two cathelicidin antimicrobial peptides, LL-37 and SMAP-29, with three bacterial polysaccharides, respectively, produced by Pseudomonas aeruginosa, Burkholderia cepacia and Klebsiella pneumoniae, was investigated to identify possible mechanisms adopted by lung pathogens to escape the action of innat...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.01.020
更新日期:2005-07-01 00:00:00
abstract::A series of Locusta adipokinetic hormone I (AKH-I), < QLNFTPNWGTa, analogues, were synthesized with modifications at the C-terminal threonine residue using a combination of solid- and liquid-phase methodology and evaluated in Locusta migratoria, in a lipid mobilization assay in vivo and an acetate uptake assay in vitr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00224-0
更新日期:1996-01-01 00:00:00
abstract::Atrial natriuretic peptide (ANP) is increasingly expressed on airway and inhibits pulmonary arterial remodeling. However, the role of ANP in remodeling of respiratory system is still unclear. The role of ANP on airway remodeling and the possible mechanism was explored in this study. Both human bronchial epithelial 16H...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.02.002
更新日期:2017-04-01 00:00:00
abstract::Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00481-6
更新日期:1998-01-01 00:00:00
abstract::In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.026
更新日期:2007-02-01 00:00:00
abstract::Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.022
更新日期:2008-10-01 00:00:00
abstract::Plasma adrenomedullin (AM) levels are elevated in various pathological states including cardiovascular and inflammatory diseases. The present study investigated whether an increased AM level is a marker of vascular complications in patients with atherosclerotic risks. In 114 patients with cardiovascular risks and/or d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.04.007
更新日期:2004-08-01 00:00:00
abstract::Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90171-x
更新日期:1992-07-01 00:00:00
abstract::Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. With the aim to further explore position 6 in the sequence of SHU-9119 and MT-II, we have designed, syn...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.02.012
更新日期:2007-06-01 00:00:00
abstract::Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90008-x
更新日期:1980-01-01 00:00:00
abstract::Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90159-7
更新日期:1985-07-01 00:00:00
abstract::The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cell...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00638-6
更新日期:2002-03-01 00:00:00
abstract::Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00253-9
更新日期:2000-07-01 00:00:00
abstract::A new, p -carborane containing analog of tyrosine, 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]alanine, was prepared from protected 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]propionic acid in five steps using Oppolzer's sultam methodology for asymmetric hydroxyamination as the key step. The tyr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00650-7
更新日期:2002-04-01 00:00:00
abstract::Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2017.11.016
更新日期:2018-02-01 00:00:00
abstract::Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90070-0
更新日期:1983-11-01 00:00:00
abstract::As part of a continuing search for potential anticancer drug candidates from antimicrobial peptides of marine organisms, tilapia (Oreochromis mossambicus) hepcidin TH2-3 was evaluated in several tumor cell lines. The results indicated that TH2-3, a synthetic 20-mer antimicrobial peptide, specifically inhibited human f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.009
更新日期:2009-09-01 00:00:00
abstract::Endokinins are novel tachykinins encoded on the human TAC4 and consist of Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of Endokinins in pain processing was not fully understood. Therefore the aim of this study was to investigate the effects of Endokinin A/B (EKA/B, the common C-terminal decap...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.10.013
更新日期:2010-01-01 00:00:00
abstract::The endangered anuran species, Odorrana ishikawae, is endemic to only two small Japanese Islands, Amami and Okinawa. To assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. Nine novel antimicrobial peptides containing the C-terminal cyclic he...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.12.013
更新日期:2011-04-01 00:00:00
abstract::In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation. PACAP also protects cereb...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2007.04.013
更新日期:2007-09-01 00:00:00
abstract::In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00108-4
更新日期:1999-01-01 00:00:00
abstract::We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00539-3
更新日期:2001-12-01 00:00:00
abstract::Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.013
更新日期:2008-06-01 00:00:00
abstract::The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90110-0
更新日期:1987-03-01 00:00:00
abstract::A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00591-5
更新日期:2002-01-01 00:00:00
abstract::Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00137-4
更新日期:1996-01-01 00:00:00