Abstract:
:Neuropeptide Y (NPY) receptor binding sites have been characterized in rat brain using both membrane preparations and receptor autoradiography. Radiolabelled NPY binds with high affinity and specificity to an apparent single class of sites in rat brain membrane preparations. The ligand selectivity pattern reveals strong similarities between central and peripheral NPY receptors. NPY receptors are discretely distributed in rat brain with high densities found in the olfactory bulb, superficial layers of the cortex, ventral hippocampus, lateral septum, various thalamic nuclei and area postrema. The presence of high densities of NPY and NPY receptors in such areas suggests that NPY could serve important functions as a major neurotransmitter/neuromodulator in the central nervous system.
journal_name
Peptidesjournal_title
Peptidesauthors
Martel JC,St-Pierre S,Quirion Rdoi
10.1016/0196-9781(86)90061-6subject
Has Abstractpub_date
1986-01-01 00:00:00pages
55-60issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(86)90061-6journal_volume
7pub_type
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