Branching patterns and projections of enteric neurons containing different putative transmitters.

abstract：:Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord....

journal_title：Peptides

authors： Naftchi NE,Abrahams SJ,St Paul HM,Vacca LL

更新日期：1981-01-01 00:00:00

abstract：:Although several low amphipathic peptides have been known to exhibit antimicrobial activity, their mode of action has not been completely elucidated. In this study, using designed low amphipathic peptides that retain different alpha-helical content and hydrophobicity, we attempted to investigate the mechanism of these...

journal_title：Peptides

authors： Yamamoto N,Tamura A

更新日期：2010-05-01 00:00:00

abstract：:This mass spectrometric study confines itself to peptide masses in the range of 500-1500Da. Adipokinetic hormones (AKHs) that are predicted from the genome of the red flour beetle, Tribolium castaneum, and the silk moth, Bombyx mori, are shown to exist as expressed peptides in the corpora cardiaca (CC) of the respecti...

journal_title：Peptides

authors： Gäde G,Marco HG,Simek P,Audsley N,Clark KD,Weaver RJ

更新日期：2008-07-01 00:00:00

abstract：:The involvement of spinal opioid receptors and spinal monoaminergic systems, in the antinociceptive effect of intrathecal (IT) salmon calcitonin, has been evaluated by means of the hot plate test, in the rat. Intrathecal pretreatment with 40 micrograms MR 1452 and 40 micrograms ICI 154,129, purported selective antagon...

journal_title：Peptides

authors： Candeletti S,Romualdi P,Spadaro C,Spampinato S,Ferri S

更新日期：1985-01-01 00:00:00

abstract：:Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin...

journal_title：Peptides

authors： Helke CJ,Selsky JH

更新日期：1983-09-01 00:00:00

abstract：:Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...

journal_title：Peptides

authors： Mattson MP,Spaziani E

更新日期：1985-07-01 00:00:00

abstract：:Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...

journal_title：Peptides

authors： Chaturvedi CM,Cornett LE,Koike TI

更新日期：1997-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs are positively charged, mucins negatively. It was the aim of the study to test whether these opposite charges result in interactions between AMPs and mucins. We measur...

journal_title：Peptides

authors： Felgentreff K,Beisswenger C,Griese M,Gulder T,Bringmann G,Bals R

更新日期：2006-12-01 00:00:00

abstract：:By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in th...

journal_title：Peptides

authors： Lundberg JM,Fahrenkrug J,Hökfelt T,Martling CR,Larsson O,Tatemoto K,Anggård A

更新日期：1984-05-01 00:00:00

abstract：:The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...

journal_title：Peptides

authors： Ferri GL,Morreale RA,Dockray GJ

更新日期：1986-09-01 00:00:00

abstract：:Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum...

journal_title：Peptides

authors： King JC,Anthony EL

更新日期：1983-11-01 00:00:00

abstract：:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...

journal_title：Peptides

authors： Reymann KG,Chepkova AN,Matthies H

更新日期：1983-05-01 00:00:00

abstract：:alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...

journal_title：Peptides

authors： Vinson GP,Whitehouse BJ,Thody AJ

更新日期：1981-07-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:Urotensin-II (U-II), a cyclic peptide widely expressed in blood vessels, has diverse vascular actions that range from potent vasoconstriction to vasodilation. Although, U-II-induced vasodilation has been shown to be partially dependent on nitric oxide (NO), the involvement of vascular adventitia-derived NO, remains un...

journal_title：Peptides

authors： Lin L,Ding WH,Jiang W,Zhang YG,Qi YF,Yuan WJ,Tang CS

更新日期：2004-11-01 00:00:00

abstract：:This study was designed to test the possibility that antimicrobial peptides could be derived from the genomic sequences of phage lysins. Using two lysins (D3 and PhiKZ) we selected and produced two putative peptides (X and Z, respectively) believed to possess antimicrobial properties based on their physicochemical cha...

journal_title：Peptides

authors： Rotem S,Radzishevsky I,Inouye RT,Samore M,Mor A

更新日期：2006-01-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:Receptor binding analysis was performed in the renal medulla from 2-month-old rats, an extrapituitary tissue containing the highest level of GHRH receptor mRNA. At 4 degrees C, in the presence of a cocktail of protease inhibitors, binding of [125I-Tyr(10)]hGHRH (1-44)NH(2) to medullary homogenates was specific, time-d...

journal_title：Peptides

authors： Boulanger L,Girard N,Strecko J,Gaudreau P

更新日期：2002-06-01 00:00:00

abstract：:The interindividual variability of the hydrolysis of leucine enkephalin, and of the formation of its hydrolysis by-products has been studied in human plasma. In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipepti...

journal_title：Peptides

authors： Marini M,Urbani A,Trani E,Bongiorno L,Roda LG

更新日期：1997-01-01 00:00:00

abstract：:High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...

journal_title：Peptides

authors： Overton RM,Vesely DL

更新日期：1996-01-01 00:00:00

abstract：:We examined the effect of adjuvant arthritis on the content of immunoreactive calcitonin gene-related peptide (iCGRP) in the dorsal root ganglia at L4-L6 levels and the spinal cord at a lumbar level in rats. Arthritis was induced by inoculating adjuvant into both hind-paws twice at a 10 day interval. In the arthritic ...

journal_title：Peptides

authors： Kuraishi Y,Nanayama T,Ohno H,Fujii N,Otaka A,Yajima H,Satoh M

更新日期：1989-03-01 00:00:00

abstract：:Mate attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, and temptin which are released during egg-laying. Other water-borne pheromones are predicted to act in concert with attractin, enticin, and temptin, but their identities were unknown. We recently identified a highl...

journal_title：Peptides

authors： Cummins SF,Nichols AE,Warso CJ,Nagle GT

更新日期：2005-03-01 00:00:00

abstract：:Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...

journal_title：Peptides

authors： Blais C Jr,Marc-Aurèle J,Simmons WH,Loute G,Thibault P,Skidgel RA,Adam A

更新日期：1999-01-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...

journal_title：Peptides

authors： Del Ry S,Cantinotti M,Cabiati M,Caselli C,Storti S,Prescimone T,Murzi B,Clerico A,Giannessi D

更新日期：2012-01-01 00:00:00

abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...

journal_title：Peptides

authors： Schwartz GJ,Moran TH,McHugh PR

更新日期：1990-11-01 00:00:00

abstract：:Japonicin-1 (FFPIGVFCKIFKTC) and japonicin-2 (FGLPMLSILPKALCILLKRKC), two peptides with differential growth-inhibitory activity against the Gram-negative bacterium, Escherichia coli and the Gram-positive bacterium Staphylococcus aureus, were isolated from an extract of the skin of the Japanese brown frog Rana japonica...

journal_title：Peptides

authors： Isaacson T,Soto A,Iwamuro S,Knoop FC,Conlon JM

更新日期：2002-03-01 00:00:00

abstract：:Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10(-9)-2.5 x 10(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in large axons had increased after ...

journal_title：Peptides

authors： Müller LJ,Moorer-van Delft CM,Boer HH

更新日期：1992-07-01 00:00:00

abstract：:Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...

journal_title：Peptides

authors： Fiedorowicz E,Jarmołowska B,Iwan M,Kostyra E,Obuchowicz R,Obuchowicz M

更新日期：2011-04-01 00:00:00

abstract：:We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...

journal_title：Peptides

authors： Stengaard-Pedersen K,Larsson LI

更新日期：1981-01-01 00:00:00

abstract：:Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), an endogenous mammalian antiopioid peptide, has been shown by other laboratories to attenuate the acute antinociceptive effects of morphine, the development of morphine tolerance, and naloxone-induced withdrawal in morphine-dependent rats. The present study determined the ef...

journal_title：Peptides

authors： Rothman RB,Brady LS,Xu H,Long JB

更新日期：1993-11-01 00:00:00