Abstract:
:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearance of additional spikes of CA1 pyramidal cells to Schaffer-commissural stimulation, which were partially antagonized by the opiate receptor antagonist naloxone. It is likely that this analgesic peptide in the hippocampus acts through mu-receptors and neuronal mechanisms already described for morphine and enkephalin analogs.
journal_name
Peptidesjournal_title
Peptidesauthors
Reymann KG,Chepkova AN,Matthies Hdoi
10.1016/0196-9781(83)90133-xsubject
Has Abstractpub_date
1983-05-01 00:00:00pages
283-6issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(83)90133-Xjournal_volume
4pub_type
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