The ACTH/MSH(4-9) analogue ORG 2766 stimulates microtubule formation in axons of central neurons of the snail Lymnaea stagnalis.

abstract：:Chicken-I and chicken-II gonadotropin-releasing hormone (cI-GnRH and cII-GnRH) were shown to be differentially distributed in the brain of a turtle, Trachemys scripta, by HPLC and specific radioimmunoassays. The cI-GnRH was most concentrated in the median eminence (ME), while cII-GnRH was most concentrated in the caud...

journal_title：Peptides

authors： Tsai PS,Licht P

更新日期：1993-03-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...

journal_title：Peptides

authors： Moriya R,Shirakura T,Hirose H,Kanno T,Suzuki J,Kanatani A

更新日期：2010-04-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:Oxytocin receptors have recently been demonstrated in human osteoblast-like (hOB) cells. In this study, oxytocin 100-1000 pmol/l increased cell proliferation of primary cultures of hOB cells, measured by [3H]thymidine incorporation, (P<0.01). In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell...

journal_title：Peptides

authors： Petersson M,Lagumdzija A,Stark A,Bucht E

更新日期：2002-06-01 00:00:00

abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...

journal_title：Peptides

authors： de Marco R,Lovato DV,Torquato RJ,Clara RO,Buarque DS,Tanaka AS

更新日期：2010-07-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:Urotensin II (UII) induces the development of cardiac remodeling and atherosclerosis by promoting hypertrophy of cardiomyocytes and mitogenesis of fibroblasts and vascular smooth muscle cells. But its effect on cardiac side population cells (CSPs), one of somatic stem cells, is unclear. The present study examined the ...

journal_title：Peptides

authors： Gong H,Ma H,Liu M,Zhou B,Zhang G,Chen Z,Jiang G,Yan Y,Yang C,Kanda M,Wu J,Yuan J,Li L,Nagai T,Komuro I,Ge J,Zou Y

更新日期：2011-05-01 00:00:00

abstract：:The corpora cardiaca (CC) of two water bug species, the water boatman Corixa punctata and the saucer bug Ilyocoris cimicoides, contain a substance that cause hyperlipemia in the migratory locust. The primary sequence of one octapeptide belonging to the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH...

journal_title：Peptides

authors： Gäde G,Simek P,Marco HG

更新日期：2007-03-01 00:00:00

abstract：:This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...

journal_title：Peptides

authors： Rao KR,Riehm JP

更新日期：1988-01-01 00:00:00

abstract：:Short synthetic peptides corresponding to sequences of complementarity-determining regions (CDRs) from different immunoglobulin families have been shown to induce antimicrobial, antiviral and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). Presently, we studied the in vitr...

journal_title：Peptides

authors： Figueiredo CR,Matsuo AL,Massaoka MH,Polonelli L,Travassos LR

更新日期：2014-09-01 00:00:00

abstract：:Methods have been developed for the microsurgical interruption of nerve pathways in the wall of the intestine and for the immunohistochemical localization of antigens in whole mounts. These methods have made it possible to determine accurately the distributions and projections of neurons containing different putative ...

journal_title：Peptides

authors： Furness JB,Costa M,Llewellyn-Smith IJ

更新日期：1981-01-01 00:00:00

abstract：:Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...

journal_title：Peptides

authors： Li A,Rinehart JP,Denlinger DL

更新日期：2009-03-01 00:00:00

abstract：:Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...

journal_title：Peptides

authors： Sakurada T,Komatsu T,Moriyama T,Sasaki M,Sanai K,Orito T,Sakurada C,Sakurada S

更新日期：2005-12-01 00:00:00

abstract：:Intrathecal injection of mice with substance P (SP) or its C-terminal fragments results in a behavioral syndrome characterized by reciprocal caudally directed biting and scratching. Repeated injection of SP, but not SP C-terminal fragments, results in a decrease in the intensity of, or desensitization to, these SP-ind...

journal_title：Peptides

authors： Igwe OJ,Sun X,Larson AA

更新日期：1990-07-01 00:00:00

abstract：:Angiotensin II (ANG II) receptors were present in the thymus of newborn rats (179 +/- 34 fmol/mg protein). In newborns, binding was predominantly localized in the trabecula, and was selectively displaced by the AT2 ligand CGP 42112A (83-85%) and to a lower extent by the AT1 antagonist losartan (15-17%), indicating a m...

journal_title：Peptides

authors： Corrêa FM,De Oliveira AM,Viswanathan M,Saavedra JM

更新日期：1994-01-01 00:00:00

abstract：:The objective of this study was to explore the effects of the endogenous opioid peptide dynorphin A(1-13) on the CNS regulation of blood pressure and heart rate. Wistar rats, anesthetized with pentobarbital and halothane, received dynorphin A(1-13) microinjected into the anterior hypothalamus area (AHA), the posterior...

journal_title：Peptides

authors： Rabkin SW

更新日期：1993-11-01 00:00:00

abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...

journal_title：Peptides

authors： Kurkowski R,Kummer W,Heym C

更新日期：1990-01-01 00:00:00

abstract：:Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. However, most of the subsequent studies failed to confirm the initially reported anorexigenic properties of obestatin. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. Here, we...

journal_title：Peptides

authors： Ren G,He Z,Cong P,Chen H,Guo Y,Yu J,Liu Z,Ji Q,Song Z,Chen Y

更新日期：2013-04-01 00:00:00

abstract：:Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...

journal_title：Peptides

authors： Zhuo JL,Li XC

更新日期：2011-07-01 00:00:00

abstract：:The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta op...

journal_title：Peptides

authors： Stanojević S,Radulović J,Kovacević-Jovanović V,Vujić V,Dimitrijević M

更新日期：2002-09-01 00:00:00

abstract：:We produced and characterized three anti-C-flanking peptides of neuropeptide Y (CPON) monoclonal antibodies. The Ka for these antibodies ranged from 0.4 to 0.8 x 10(8) l/mol with an IC50 for CPON(1-30) at about 20 nM as determined by ELISA. All these antibodies are IgG1 and recognize the 16-30 part of CPON. These anti...

journal_title：Peptides

authors： Grouzmann E,Alvarez-Bolado G,Meyer C,Osterheld MC,Burnier M,Brunner HR,Waeber B

更新日期：1994-01-01 00:00:00

abstract：:Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...

journal_title：Peptides

authors： Larsen PJ,Jessop DS,Chowdrey HS,Mikkelsen JD,Lightman SL

更新日期：1992-07-01 00:00:00

abstract：:Binding studies have shown that [125I]NKA is a selective ligand of tachykinin septide-sensitive binding sites from membranes of the rat submaxillary gland. Indeed, this ligand bound with high affinity to a single population of sites. In addition, competition studies indicated that natural tachykinins and tachykinin-re...

journal_title：Peptides

authors： Beaujouan JC,Saffroy M,Torrens Y,Sagan S,Glowinski J

更新日期：1999-11-01 00:00:00

abstract：:DDSDEEN chromatin peptide, after dansylation, was studied for its ability to bind N-CAM protein. The binding causes a quenching of the Dns-peptide fluorescence emission. Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown. Fluorescence quenching is completely lost if the Dns-peptide is subjected ...

journal_title：Peptides

authors： Marsili V,Lupidi G,Berellini G,Calzuola I,Perni S,Cruciani G,Gianfranceschi GL

更新日期：2008-12-01 00:00:00

abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...

journal_title：Peptides

authors： Howl J,Howl L,Jones S

更新日期：2018-03-01 00:00:00

abstract：:This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers i...

journal_title：Peptides

authors： Chronwall BM,Zukowska Z

更新日期：2004-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...

journal_title：Peptides

authors： Aldegunde M,Mancebo M

更新日期：2006-04-01 00:00:00

abstract：:VIP receptors on blood mononuclear leucocytes and plasma VIP concentrations were studied during a ranger training course lasting for five days with almost continuous physical activity, and energy deficiency. The maximum binding capacity (Bmax) for the high affinity receptor increased (p less than 0.0005) from 0.71 (SE...

journal_title：Peptides

authors： Wiik P,Opstad PK,Knardahl S,Bøyum A

更新日期：1988-01-01 00:00:00