Receptors for vasoactive intestinal peptide (VIP) on human mononuclear leucocytes are upregulated during prolonged strain and energy deficiency.

abstract：:In present study, we aimed to identify angiotensin I-converting enzyme (ACE)-inhibitory peptides from a salt-free soy sauce (SFS), a newly developed antihypertensive seasoning obtained by Aspergillus oryzae fermentation of soybean in the absence of salt, which can be transported through caco-2 cell monolayers. Through...

journal_title：Peptides

authors： Zhu XL,Watanabe K,Shiraishi K,Ueki T,Noda Y,Matsui T,Matsumoto K

更新日期：2008-03-01 00:00:00

abstract：:The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3 position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of physiological functions, affecting GH release, food intake, energy and glucose homeostasis, gastrointestinal, cardiovascular, pulmonary and ...

journal_title：Peptides

authors： Soares JB,Leite-Moreira AF

更新日期：2008-07-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:Mustard oil, which stimulates small diameter afferents, was used to evoke the expression of the oncogene c-fos in the lumbar spinal cord. C-fos-like immunoreactivity was concentrated in, but not limited to, neuronal nuclei of laminae I and II of the lumbar dorsal horn. Double-label immunocytochemistry was used to dete...

journal_title：Peptides

authors： Pretel S,Piekut DT

更新日期：1991-11-01 00:00:00

abstract：:Obesity is a chronic inflammatory disease significantly risen worldwide, especially among children. Adipokines, secreted from adipose tissue, are hormones involved in various cellular processes such as energy metabolism and inflammation. Among the others, adiponectin is gaining increasing interest for its insulin-sent...

journal_title：Peptides

authors： Nigro E,Piombino P,Scudiero O,Monaco ML,Schettino P,Chambery A,Daniele A

更新日期：2015-01-01 00:00:00

abstract：:Treatment of cultured rat hepatocytes with cyclosporin A (0.01-1 microM) for 24, 48, or 72 h in the presence of insulin and epidermal growth factor induced an inhibition on cell proliferation in a time- and concentration-dependent manner, with an IC50 = 0.05 microM CsA corresponding to 48-h treatment. The inhibitory e...

journal_title：Peptides

authors： Rodriguez-Henche N,Román ID,Fueyo J,Menor C,Zueco JA,Prieto JC,Guijarro LG

更新日期：1998-01-01 00:00:00

abstract：:Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...

journal_title：Peptides

authors： Han RW,Chang M,Peng YL,Qiao LY,Yin XQ,Li W,Wang R

更新日期：2009-07-01 00:00:00

abstract：:In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...

journal_title：Peptides

authors： Li W,Zheng S,Tang C,Zhu Y,Wang X

更新日期：2007-06-01 00:00:00

abstract：:In sheep, arginine vasopressin (AVP) and corticotropin-releasing factor (CRF) stimulate adrenocorticotropic hormone (ACTH) secretion. Increased hypothalamic secretion of these peptides at the end of gestation initiates parturition in this species. We hypothesized that CRF and/or AVP content in the fetal hypothalamus i...

journal_title：Peptides

authors： Saoud CJ,Wood CE

更新日期：1996-01-01 00:00:00

abstract：:Recent data suggests that neurons expressing the long form of the leptin receptor form at least two distinct groups within the caudal nucleus of the solitary tract (NTS): a group within the lateral NTS (Slt) and one within the medial (Sm) and gelantinosa (Sg) NTS. Discrete injections of leptin into Sm and Sg, a region...

journal_title：Peptides

authors： Ciriello J

更新日期：2013-06-01 00:00:00

abstract：:The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitu...

journal_title：Peptides

authors： Feng X,Liu T,Wang F,Cao R,Zhou B,Zhang Y,Mao X,Chen P,Zhang H

更新日期：2011-06-01 00:00:00

abstract：:We have investigated the effect of amyloid beta-peptide (Abeta) in rat pheochromocytoma PC 12h and murine C 1300 neuroblastoma cells by using MTT ¿3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction assay. Exposure of the cells to Abeta peptides, Abeta1-40 and its fragment Abeta25-35, induced a con...

journal_title：Peptides

authors： Takenouchi T,Munekata E

更新日期：1998-01-01 00:00:00

abstract：:As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...

journal_title：Peptides

authors： Wang K,Yan J,Dang W,Liu X,Chen R,Zhang J,Zhang B,Zhang W,Kai M,Yan W,Yang Z,Xie J,Wang R

更新日期：2013-01-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:Large species differences have been previously observed in the pharmacology of bradykinin (BK) B2 receptor antagonists. We investigated the effect of two novel non-peptide antagonists, compound 9 (a benzodiazepine peptidomimetic related to icatibant) and the thiosemicarbazide bradyzide on the rabbit B2 receptor (contr...

journal_title：Peptides

authors： Marceau F,Houle S,Bouthillier J,Said NB,Garratt PJ,Dziadulewicz EK

更新日期：2001-09-01 00:00:00

abstract：:A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...

journal_title：Peptides

authors： Anderson WG,Leprince J,Conlon JM

更新日期：2008-08-01 00:00:00

abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...

journal_title：Peptides

authors： Ruellan C,Scemama JL,Clerc P,Fagot-Revurat P,Clemente F,Ribet A

更新日期：1986-01-01 00:00:00

abstract：:We recently discovered that vascular responsiveness to adrenomedullin (AM), a vasoactive hormone, decreases after hemorrhage, which is markedly improved by the addition of its binding protein AMBP-1. One obstacle hampering the development of AM/AMBP-1 as resuscitation agents in trauma victims is the potential immunoge...

journal_title：Peptides

authors： Wu R,Dong W,Qiang X,Ji Y,Cui T,Yang J,Zhou M,Blau S,Marini CP,Ravikumar TS,Wang P

更新日期：2008-07-01 00:00:00

abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

journal_title：Peptides

authors： Shetzline MA,Zipf WB,Nishikawara MT

更新日期：1998-01-01 00:00:00

abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...

journal_title：Peptides

authors： Hewlett WA,Barchas JD

更新日期：1983-11-01 00:00:00

abstract：:Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...

journal_title：Peptides

authors： Toneff T,Funkelstein L,Mosier C,Abagyan A,Ziegler M,Hook V

更新日期：2013-08-01 00:00:00

abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...

journal_title：Peptides

authors： Tammen H,Hess R,Rose H,Wienen W,Jost M

更新日期：2008-12-01 00:00:00

abstract：:Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point value...

journal_title：Peptides

authors： Cytryńska M,Mak P,Zdybicka-Barabas A,Suder P,Jakubowicz T

更新日期：2007-03-01 00:00:00

abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...

journal_title：Peptides

authors： Yalow RS,Eng J

更新日期：1981-01-01 00:00:00

abstract：:To study structure-activity relationships of growth hormone-releasing hormone (GHRH), a competitive binding assay was developed using cloned porcine adenopituitary GHRH receptors expressed in human kidney 293 cells. Specific binding of [His1, 125I-Tyr10,Nle27]hGHRH(1-32)-NH2 increased linearly with protein concentrati...

journal_title：Peptides

authors： Hassan HA,Hsiung HM,Zhang XY,Smith DP,Smiley DL,Heiman ML

更新日期：1995-01-01 00:00:00

abstract：:CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...

journal_title：Peptides

authors： Maixnerová J,Hlavácek J,Blokesová D,Kowalczyk W,Elbert T,Sanda M,Blechová M,Zelezná B,Slaninová J,Maletínská L

更新日期：2007-10-01 00:00:00

abstract：:Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...

journal_title：Peptides

authors： Huang YH,Yang YL,Tiao MM,Kuo HC,Huang LT,Chuang JH

更新日期：2012-06-01 00:00:00

abstract：:Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...

journal_title：Peptides

authors： Scallet AC,Della-Fera MA,Baile CA

更新日期：1985-09-01 00:00:00

abstract：:Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...

journal_title：Peptides

authors： Lloyd PE,Kupfermann I,Weiss KR

更新日期：1987-01-01 00:00:00

abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...

journal_title：Peptides

authors： Sanders HM,Lust R,Teller JK

更新日期：2009-05-01 00:00:00