Characterization of growth hormone-releasing hormone (GHRH) binding to cloned porcine GHRH receptor.

abstract：:To characterize the endothelin (ET) receptor that mediates the contraction induced by ET-1 in the porcine myometrium, we carried out a contraction study, radioligand binding study and molecular study (reverse transcription polymerase chain reaction) for detection of ET receptor-coding genes (mRNA). ET-1 (1 nM-1 microM...

journal_title：Peptides

authors： Isaka M,Takaoka K,Yamada Y,Abe Y,Kitazawa T,Taneike T

更新日期：2000-04-01 00:00:00

abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

journal_title：Peptides

authors： Tanaka J,Kariya K,Nomura M

更新日期：2003-06-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:Urotensin II (UII), which was originally isolated from the teleost urophysis, was identified as an endogenous ligand for orphan G protein-coupled receptor 14 (GPR14). The structure of mammalian UII was confirmed by isolation from spinal cord in porcine, or was easily predicted from the sequence of prepro-UII in human....

journal_title：Peptides

authors： Sugo T,Mori M

更新日期：2008-05-01 00:00:00

abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...

journal_title：Peptides

authors： Davis J,Jones A,Lewis RJ

更新日期：2009-07-01 00:00:00

abstract：:The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...

journal_title：Peptides

authors： McCormack AM,Carter RJ,Thody AJ,Shuster S

更新日期：1982-01-01 00:00:00

abstract：:Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...

journal_title：Peptides

authors： Lloyd PE,Kupfermann I,Weiss KR

更新日期：1987-01-01 00:00:00

abstract：:We labeled substance P (SP), neurokinin A (NKA), and [Lys0]gastrin-releasing peptide-27 (GRP) with cyanine 3.18 (cy3). Cy3-peptides purified by HPLC were fully active, determined by [Ca2+]i mobilization. Binding was specific because it was abolished by unlabeled peptides and receptor antagonists. Transfected cells yie...

journal_title：Peptides

authors： Bunnett NW,Dazin PF,Payan DG,Grady EF

更新日期：1995-01-01 00:00:00

abstract：:The interaction of two cathelicidin antimicrobial peptides, LL-37 and SMAP-29, with three bacterial polysaccharides, respectively, produced by Pseudomonas aeruginosa, Burkholderia cepacia and Klebsiella pneumoniae, was investigated to identify possible mechanisms adopted by lung pathogens to escape the action of innat...

journal_title：Peptides

authors： Herasimenka Y,Benincasa M,Mattiuzzo M,Cescutti P,Gennaro R,Rizzo R

更新日期：2005-07-01 00:00:00

abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...

journal_title：Peptides

authors： Asakawa A,Inui A,Ueno N,Fujimiya M,Fujino MA,Kasuga M

更新日期：1999-12-01 00:00:00

abstract：:The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of insect species. A previous solution conformation study of an active, restricted-conformation cyclic analog, identified two possible turn conformations as the likel...

journal_title：Peptides

authors： Nachman RJ,Zabrocki J,Olczak J,Williams HJ,Moyna G,Ian Scott A,Coast GM

更新日期：2002-04-01 00:00:00

abstract：:Alternaria alternata protein, Alt a 1 is a major allergen associated with allergy in atopic patients. Although the molecule binds strongly to IgE antibody from patients, the epitopes involved have not been identified or defined. In the present study, we synthesized overlapping peptides spanning the whole sequence and ...

journal_title：Peptides

authors： Kurup VP,Vijay HM,Kumar V,Castillo L,Elms N

更新日期：2003-02-01 00:00:00

abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...

journal_title：Peptides

authors： Bender T,Török I,Barna I,Géher P

更新日期：2001-04-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)] develops its functions interacting with Mas receptor. Mas receptor was recently identified in the DRG and its activation by Ang-(1-7) resulted in peripheral antinociception against PGE2 hyperalgesia in an opioid-independent pathway. Nevertheless, the mechanism by which Ang-(1-7) induce pe...

journal_title：Peptides

authors： Castor MG,Santos RA,Duarte ID,Romero TR

更新日期：2015-07-01 00:00:00

abstract：:The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...

journal_title：Peptides

authors： Santiago JCP,Otto M,Kern W,Baier PC,Hallschmid M

更新日期：2018-04-01 00:00:00

abstract：:Ghrelin is a peptide that has protective effects on many tissues of the body. It has anti-inflammatory and anti-oxidant effects. Acetaminophen, a commonly used analgesic-antipyretic drug, has hepatotoxic side effects. The aim of this study was to evaluate the protective role of ghrelin in liver toxicity due to acetami...

journal_title：Peptides

authors： Golestan Jahromi M,Nabavizadeh F,Vahedian J,Nahrevanian H,Dehpour AR,Zare-Mehrjardi A

更新日期：2010-11-01 00:00:00

abstract：:Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patient...

journal_title：Peptides

authors： Liu L,Ding W,Li R,Ye X,Zhao J,Jiang J,Meng L,Wang J,Chu S,Han X,Peng F

更新日期：2013-08-01 00:00:00

abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...

journal_title：Peptides

authors： Palm S,Roman E,Nylander I

更新日期：2012-07-01 00:00:00

abstract：:Plasmodium falciparum malaria parasite invasion of erythrocytes is an essential step in host infection and the proteins involved in such invasion are the main target in developing an antimalarial vaccine. Secretory organelle-derived proteins (micronemal AMA1 protein and the RON2, 4, and 5 rhoptry neck proteins) have b...

journal_title：Peptides

authors： Curtidor H,Patiño LC,Arévalo-Pinzón G,Vanegas M,Patarroyo ME,Patarroyo MA

更新日期：2014-03-01 00:00:00

abstract：:The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...

journal_title：Peptides

authors： Singh R,Rai U

更新日期：2009-06-01 00:00:00

abstract：:Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, ...

journal_title：Peptides

authors： Pavone F,Populin R,Castellano C,Kreil G,Melchiorri P

更新日期：1990-05-01 00:00:00

abstract：:An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...

journal_title：Peptides

authors： Weindl A,Triepel J,Kuchling G

更新日期：1984-01-01 00:00:00

abstract：:The intracranial injection of an opioid antagonist (naloxone) caused aggregation of xanthophores in goldfish scales. This aggregating effect produced by naloxone was inhibited by an injection of methionine-enkephalin (M-ENK). M-ENK, when injected together with melatonin which normally produces aggregation of xanthopho...

journal_title：Peptides

authors： Satake N

更新日期：1980-04-01 00:00:00

abstract：:To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...

journal_title：Peptides

authors： Sakurada S,Hayashi T,Yuhki M,Fujimura T,Murayama K,Yonezawa A,Sakurada C,Takeshita M,Sato T,Zadina JE,Kastin AJ,Sakurada T

更新日期：2002-05-01 00:00:00

abstract：:Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...

journal_title：Peptides

authors： Muramatsu Y,Fukushima K,Iino K,Totsune K,Takahashi K,Suzuki T,Hirasawa G,Takeyama J,Ito M,Nose M,Tashiro A,Hongo M,Oki Y,Nagura H,Sasano H

更新日期：2000-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...

journal_title：Peptides

authors： Kinhult J,Egesten A,Uddman R,Cardell LO

更新日期：2002-10-01 00:00:00

abstract：:The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...

journal_title：Peptides

authors： Bennett-Clarke CA,Joseph SA

更新日期：1986-09-01 00:00:00

abstract：:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

journal_title：Peptides

authors： Garczynski SF,Crim JW,Brown MR

更新日期：2007-01-01 00:00:00

abstract：:NLP-12a and b have been identified as cholecystokinin/sulfakinin-like neuropeptides in the free-living nematode Caenorhabditis elegans. They are suggested to play an important role in the regulation of digestive enzyme secretion and fat storage. This study reports on the identification and characterization of an NLP-1...

journal_title：Peptides

authors： Peeters L,Janssen T,De Haes W,Beets I,Meelkop E,Grant W,Schoofs L

更新日期：2012-03-01 00:00:00

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00