Abstract:
:Alternaria alternata protein, Alt a 1 is a major allergen associated with allergy in atopic patients. Although the molecule binds strongly to IgE antibody from patients, the epitopes involved have not been identified or defined. In the present study, we synthesized overlapping peptides spanning the whole sequence and evaluated their IgE binding with sera from patients with Alternaria-induced allergy. The results identified four IgE binding linear regions. Two of these regions K41-P50 and Y54-K63 showed consistent reactivity with all four patients studied. The specific epitopes involved in the immune response may be of value in the immunodiagnosis and probably also in specific immunotherapy.
journal_name
Peptidesjournal_title
Peptidesauthors
Kurup VP,Vijay HM,Kumar V,Castillo L,Elms Ndoi
10.1016/s0196-9781(03)00024-xsubject
Has Abstractpub_date
2003-02-01 00:00:00pages
179-85issue
2eissn
0196-9781issn
1873-5169pii
S019697810300024Xjournal_volume
24pub_type
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