Cardiovascular effects of a PEGylated apelin.

abstract：:Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the p...

journal_title：Peptides

authors： Abdelalim EM,Tooyama I

更新日期：2010-01-01 00:00:00

abstract：:The influence of peripheral somatostatin immunoneutralization on intravenous (i.v.) and intracerebroventricular (ICV) bombesin-induced inhibition of gastric acid secretion (GAS) was investigated with the somatostatin monoclonal antibody, CURE.S6, in rats. The somatostatin antibody, injected i.v. in conscious rats with...

journal_title：Peptides

authors： Martínez V,Yang H,Wong HC,Walsh JH,Taché Y

更新日期：1995-01-01 00:00:00

abstract：:Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...

journal_title：Peptides

authors： Wolf SS,Moody TW

更新日期：1985-01-01 00:00:00

abstract：:We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...

journal_title：Peptides

authors： Stengaard-Pedersen K,Larsson LI

更新日期：1981-01-01 00:00:00

abstract：:High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...

journal_title：Peptides

authors： Overton RM,Vesely DL

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...

journal_title：Peptides

authors： Philipp E,Wilckens T,Friess E,Platte P,Pirke KM

更新日期：1992-01-01 00:00:00

abstract：:The reperfusion injury salvage kinase (RISK) pathway is a fundamental signal transduction cascade in the cardioprotective mechanism of ischemic postconditioning. In the present study, we examined the cardioprotective role of oxytocin as a postconditioning agent via activation of the RISK pathway (PI3K/Akt and ERK1/2)....

journal_title：Peptides

authors： Polshekan M,Jamialahmadi K,Khori V,Alizadeh AM,Saeidi M,Ghayour-Mobarhan M,Jand Y,Ghahremani MH,Yazdani Y

更新日期：2016-12-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is expressed in the vascular endothelium. It is not known whether CNP is specifically increased in patients with idiopathic left ventricular systolic dysfunction (ILVDys) with or without overt heart failure, and whether in these patients it is related with indicators of myocardial and/...

journal_title：Peptides

authors： Del Ry S,Giannessi D,Maltinti M,Prontera C,Iervasi A,Colotti C,Emdin M,L'Abbate A,Neglia D

更新日期：2007-05-01 00:00:00

abstract：:It is well known that glucoprivation induces the release of counterregulatory hormones such as glucagon, and that the response is attenuated when the stimuli are repeated. Glucoprivation also activates orexigenic neurons and induces hyperphagic responses, although it remains unclear whether these responses are attenua...

journal_title：Peptides

authors： Ozawa Y,Arima H,Watanabe M,Shimizu H,Ito Y,Banno R,Sugimura Y,Ozaki N,Nagasaki H,Oiso Y

更新日期：2011-04-01 00:00:00

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:Leptin signaling in the hypothalamus is critical for normal food intake and body weight regulation. Cumulative evidence suggests that besides the signal transducer and activator of transcription-3 (STAT3) pathway, several non-STAT3 pathways including the phosphodiesterase-3B (PDE3B) pathway mediate leptin signaling in...

journal_title：Peptides

authors： Sahu M,Sahu A

更新日期：2015-11-01 00:00:00

abstract：:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...

journal_title：Peptides

authors： Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JM

更新日期：1992-07-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...

journal_title：Peptides

authors： Del Ry S,Maltinti M,Cabiati M,Emdin M,Giannessi D,Morales MA

更新日期：2008-01-01 00:00:00

abstract：:Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 microgram/kg IP and 0.5-5.0 microgram/IVT, indicating a peripheral mechanism in ...

journal_title：Peptides

authors： Crawley JN,Hays SE,O'Donohue TL,Paul SM,Goodwin FK

更新日期：1981-01-01 00:00:00

abstract：:Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they are considered an important public health threat. In order to identify some of their naturally occurring toxin peptides available in very low amounts, we combine analytical protocols suc...

journal_title：Peptides

authors： Conceição K,Santos JM,Bruni FM,Klitzke CF,Marques EE,Borges MH,Melo RL,Fernandez JH,Lopes-Ferreira M

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). METHODS:Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anestheti...

journal_title：Peptides

authors： Yuan K,Kim SY,Oh YB,Yu J,Shah A,Park BH,Kim SH

更新日期：2010-07-01 00:00:00

abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...

journal_title：Peptides

authors： Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MV

更新日期：2010-11-01 00:00:00

abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...

journal_title：Peptides

authors： Hoover DB

更新日期：1991-09-01 00:00:00

abstract：:Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...

journal_title：Peptides

authors： Okuno A,Hasegawa Y,Ohira T,Nagasawa H

更新日期：2001-02-01 00:00:00

abstract：:The cross-immunoreactivity, topography, and fiber projections of the alpha MSH-immunoreactive specific neurons in the forebrain of the rat appear to be distinctly different from that of the neurons in the hypothalamic arcuate opiocortin system. The cell bodies, immunoreactive only to alpha-MSH, have a specific pattern...

journal_title：Peptides

authors： Piekut DT,Knigge KM

更新日期：1984-11-01 00:00:00

abstract：:Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Usi...

journal_title：Peptides

authors： Kumar P,Arise KK,Pandey KN

更新日期：2006-07-01 00:00:00

abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...

journal_title：Peptides

authors： Shoji I,Hirose T,Mori N,Hiraishi K,Kato I,Shibasaki A,Yamamoto H,Ohba K,Kaneko K,Morimoto R,Satoh F,Kohzuki M,Totsune K,Takahashi K

更新日期：2010-10-01 00:00:00

abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...

journal_title：Peptides

authors： Ruellan C,Scemama JL,Clerc P,Fagot-Revurat P,Clemente F,Ribet A

更新日期：1986-01-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...

journal_title：Peptides

authors： Toneff T,Funkelstein L,Mosier C,Abagyan A,Ziegler M,Hook V

更新日期：2013-08-01 00:00:00

abstract：:Neuromedin B (NMB), which was originally isolated from porcine spinal cord, is a mammalian bombesin-related peptide that exerts various physiological effects. Previously, we observed expression of NMB in rib cartilage from chicken. Here, we report the initial attempt to elucidate the role of NMB in cartilage. We used ...

journal_title：Peptides

authors： Saito H,Ikeda R,Inoue K,Nagata S,Kitamura K,Minamino N,Kangawa K,Miyata A

更新日期：2012-08-01 00:00:00

abstract：:Guinea pig VIP differs from VIP of several mammals by its amino acids in positions 5, 9, 19 and 26. We tested a) its ability to occupy VIP receptors in liver and lung membranes of rat and guinea pig and in the human lymphoblastic SUP-T1 cell line and b) the ensuing adenylate cyclase stimulation. In liver and lung memb...

journal_title：Peptides

authors： Cauvin A,Buscail L,Gourlet P,De Neef P,Robberecht P,Yanaihara N,Christophe J

更新日期：1991-01-01 00:00:00

abstract：:Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...

journal_title：Peptides

authors： Mazarguil H,Mollereau C,Czaplicki G,Zajac JM

更新日期：2012-09-01 00:00:00

abstract：:In this study, an amphibian (Odorrana hejiangensis) skin extract was fractionated by reverse phase HPLC and fractions were screened for trypsin inhibitory activity. Using this initial approach, a novel trypsin inhibitory peptide was detected with an apparent protonated molecular mass of 1804.83 Da, as determined by MA...

journal_title：Peptides

authors： Wang M,Wang L,Chen T,Walker B,Zhou M,Sui D,Conlon JM,Shaw C

更新日期：2012-02-01 00:00:00

abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...

journal_title：Peptides

authors： Betourne A,Marty V,Ceccom J,Halley H,Lassalle JM,Zajac JM,Frances B,Mouledous L

更新日期：2010-02-01 00:00:00