Central locomotor and cognitive effects of a NPFF receptor agonist in mouse.

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:A series of Locusta adipokinetic hormone I (AKH-I), < QLNFTPNWGTa, analogues, were synthesized with modifications at the C-terminal threonine residue using a combination of solid- and liquid-phase methodology and evaluated in Locusta migratoria, in a lipid mobilization assay in vivo and an acetate uptake assay in vitr...

journal_title：Peptides

authors： Lee MJ,Goldsworthy GJ,Poulos CP,Velentza A

更新日期：1996-01-01 00:00:00

abstract：:The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential ant...

journal_title：Peptides

authors： Brouwer CP,Bogaards SJ,Wulferink M,Velders MP,Welling MM

更新日期：2006-11-01 00:00:00

abstract：:The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...

journal_title：Peptides

authors： Singh R,Rai U

更新日期：2009-06-01 00:00:00

abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...

journal_title：Peptides

authors： Melrose PA,Knigge KM

更新日期：1985-03-01 00:00:00

abstract：:The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum diluti...

journal_title：Peptides

authors： Kovcs A,Telegdy G

更新日期：1994-01-01 00:00:00

abstract：:The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on th...

journal_title：Peptides

authors： Meisenberg G

更新日期：1981-04-01 00:00:00

abstract：:This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in controlling autoimmune diseases or inducing immunotolerance. ICAM-1/LFA-1 interaction is essential for T-cell activation as well as for migration of T-cells to targe...

journal_title：Peptides

authors： Anderson ME,Siahaan TJ

更新日期：2003-03-01 00:00:00

abstract：:Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

journal_title：Peptides

authors： Dees WL,Kozlowski GP

更新日期：1984-01-01 00:00:00

abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...

journal_title：Peptides

authors： Tang J,Song DL,Suen MZ,Xie CW,Chang D,Chang JK

更新日期：1986-01-01 00:00:00

abstract：:We labeled substance P (SP), neurokinin A (NKA), and [Lys0]gastrin-releasing peptide-27 (GRP) with cyanine 3.18 (cy3). Cy3-peptides purified by HPLC were fully active, determined by [Ca2+]i mobilization. Binding was specific because it was abolished by unlabeled peptides and receptor antagonists. Transfected cells yie...

journal_title：Peptides

authors： Bunnett NW,Dazin PF,Payan DG,Grady EF

更新日期：1995-01-01 00:00:00

abstract：:Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides lowered blood pressure of spontaneously hypertensive rats (SHR)...

journal_title：Peptides

authors： Marczak ED,Usui H,Fujita H,Yang Y,Yokoo M,Lipkowski AW,Yoshikawa M

更新日期：2003-06-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

journal_title：Peptides

authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

更新日期：2012-11-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:This work showed the effect of pheromone plantaricin A (PlnA) on the proliferation and migration of the human keratinocytes NCTC 2544. PlnA was chemically synthesized and used as pure peptide or biologically synthesized during co-cultivation of Lactobacillus plantarum DC400 and Lactobacillus sanfranciscensis DPPMA174....

journal_title：Peptides

authors： Pinto D,Marzani B,Minervini F,Calasso M,Giuliani G,Gobbetti M,De Angelis M

更新日期：2011-09-01 00:00:00

abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

journal_title：Peptides

authors： Peters J

更新日期：2012-04-01 00:00:00

abstract：:We have previously shown that brief, vena caval infusion of gastrin-releasing peptide1-27 (GRP), delivered shortly (5 min) after the end of the first spontaneous nocturnal meal, significantly prolongs the postprandial intermeal interval (IMI) without affecting the size of the subsequent meal in freely-feeding rats. In...

journal_title：Peptides

authors： Rushing PA,Gibbs J

更新日期：1998-01-01 00:00:00

abstract：:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...

journal_title：Peptides

authors： Theodorsson-Norheim E

更新日期：1983-07-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and endothelin (ET) are endogenous vasoactive factors that exert potent diuretic and natriuretic actions. We have previously shown that ANP and ET-3 act through an NO pathway to inhibit the sodium-glucose cotransporter (SGLT) in the intestine [Gonzalez Bosc LV, Elustondo PA, Ortiz MC, ...

journal_title：Peptides

authors： Majowicz MP,Gonzalez Bosc LV,Albertoni Borghese MF,Delgado MF,Ortiz MC,Sterin Speziale N,Vidal NA

更新日期：2003-12-01 00:00:00

abstract：:The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...

journal_title：Peptides

authors： Sharif NA,Hughes J

更新日期：1989-05-01 00:00:00

abstract：:In situ hybridization techniques have been developed that quantitate the relative levels of specific mRNAs in individual cell types of a heterogeneous tissue, the mammalian brain. Here, we discuss those special procedures and precautions necessary for hybridizing radiolabeled probes to developing and adult brain mRNAs...

journal_title：Peptides

authors： Griffin WS,Morrison MR

更新日期：1985-01-01 00:00:00

abstract：:Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...

journal_title：Peptides

authors： Ott MC,Costain WJ,Mishra RK,Johnson RL

更新日期：2000-02-01 00:00:00

abstract：:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise G

更新日期：1999-11-01 00:00:00

abstract：:A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...

journal_title：Peptides

authors： Anderson WG,Leprince J,Conlon JM

更新日期：2008-08-01 00:00:00

abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...

journal_title：Peptides

authors： Yalow RS,Eng J

更新日期：1981-01-01 00:00:00

abstract：:High plasma copeptin level has been associated with one-month mortality after traumatic brain injury. However, not much is known regarding its relation with long-term outcome. Thus, we investigated the ability of copeptin to predict 1-year outcome in patients with traumatic brain injury. One hundred and six healthy co...

journal_title：Peptides

authors： Yu GF,Huang Q,Dai WM,Jie YQ,Fan XF,Wu A,Lv Y,Li YP,Yan XJ

更新日期：2012-01-01 00:00:00

abstract：:The study was undertaken to investigate the oxidation and reduction of cholecystokinin (CCK) both as pure standards and as endogenous porcine peptides. Furthermore an attempt was made to prevent oxidation of the endogenous porcine peptides in the extraction procedure. CCK-8 and CCK-33 standards were always oxidized in...

journal_title：Peptides

authors： Bacarese-Hamilton AJ,Adrian TE,Chohan P,Antony T,Bloom SR

更新日期：1985-01-01 00:00:00

abstract：:Radiation enteritis occurs as a response to abdominal radiation, which can cause mucosal damage in the gastrointestinal mucosal epithelium. The small intestine is one of the most radiosensitive organs in the abdomen. The present study was undertaken to investigate the effect of octreotide (OCT) administration on heme ...

journal_title：Peptides

authors： Abbasoğlu SD,Erbil Y,Eren T,Giriş M,Barbaros U,Yücel R,Olgaç V,Uysal M,Toker G

更新日期：2006-06-01 00:00:00

abstract：:Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...

journal_title：Peptides

authors： Pennefather JN,Reynoldson NA,Handberg GM

更新日期：1990-09-01 00:00:00