Abstract:
:The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential antimicrobial activity of ubiquicidin and small synthetic fragments thereof towards methicillin resistant Staphylococcus aureus (MRSA), as a high priority target for novel antibiotics. In vitro killing of MRSA by synthetic peptides derived from the alpha-helix or beta-sheet domains of the human cationic peptide ubiquicidin (UBI 1-59), allowed selection of AMPs for possible treatment of MRSA infections. The strongest antibacterial activity was observed for the entire peptide UBI 1-59 and for synthetic fragments comprising amino acids 31-38. The availability, chemical synthesis opportunities, and size of these small peptides, combined with their strong antimicrobial activity towards MRSA make these compounds promising candidates for antimicrobial therapy and detection of infections in man.
journal_name
Peptidesjournal_title
Peptidesauthors
Brouwer CP,Bogaards SJ,Wulferink M,Velders MP,Welling MMdoi
10.1016/j.peptides.2006.05.022subject
Has Abstractpub_date
2006-11-01 00:00:00pages
2585-91issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00257-9journal_volume
27pub_type
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