Abstract:
:Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.
journal_name
Peptidesjournal_title
Peptidesauthors
Corwin RL,Corp ES,Gibbs J,Smith GPdoi
10.1016/0196-9781(92)90031-wsubject
Has Abstractpub_date
1992-11-01 00:00:00pages
1215-8issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(92)90031-Wjournal_volume
13pub_type
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