Abstract：
:Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses known to inhibit food consumption, and of (c) lithium chloride, at doses known to produce taste aversion. Parameters of exploration of a novel arena surface and investigation of a novel object placed in the center of the arena were analyzed by an automated video-tracking computer-assisted animal behavior monitor. Cholecystokinin reduced all parameters of exploration. Ingestion of at least one gram of chocolate chip cookie also reduced all exploratory parameters. Bombesin reduced only parameters of approach to the novel object and the center of the arena. Lithium chloride reduced only parameters of approach to the novel object and the center of the arena. CCK may influence exploratory behaviors through mechanisms similar to those produced by ingestion of palatable food, but somewhat different from those produced by lithium and bombesin.
journal_name
Peptidesjournal_title
Peptidesauthors
Crawley JNdoi
10.1016/0196-9781(83)90040-2subject
Has Abstractpub_date
1983-07-01 00:00:00pages
405-10issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(83)90040-2journal_volume
4pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.01.007
更新日期：2013-04-01 00:00:00
abstract：:Insect flight requires rapid mobilization of energy reserves during flight, which is mediated and regulated by hormonal control via adipokinetic hormones. The structure of the G-protein receptors to which these hormones bind, are crucial in understanding many of the physiological processes in which they play a central...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.08.017
更新日期：2011-03-01 00:00:00
abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00104-1
更新日期：1998-01-01 00:00:00
abstract：:This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.02.019
更新日期：2013-06-01 00:00:00
abstract：:We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.010
更新日期：2006-12-01 00:00:00
abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00158-3
更新日期：1995-01-01 00:00:00
abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90425-5
更新日期：1985-11-01 00:00:00
abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2016.01.015
更新日期：2016-04-01 00:00:00
abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.04.016
更新日期：2012-07-01 00:00:00
abstract：:Ghrelin is broadly expressed in myocardial tissues, where it exerts different functions. It also has been found to have a wide variety of biological functions on cell differentiation and tissue development. The aim of this study was to investigate the effect of ghrelin on human embryonic stem cell (hESC) differentiati...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.02.006
更新日期：2012-04-01 00:00:00
abstract：:The emergence of multidrug-resistant strains of Neisseria gonorrhoeae constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. Among the 18 clinical isolates of N. gonorrhoeae with susceptible to spectinomycin, ceftriaxone and cefixime, 14 isolates were resista...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression anal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00195-9
更新日期：2000-05-01 00:00:00
abstract：:Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90176-4
更新日期：1992-07-01 00:00:00
abstract：:Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.07.002
更新日期：2013-03-01 00:00:00
abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.03.005
更新日期：2012-05-01 00:00:00
abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.09.030
更新日期：2007-02-01 00:00:00
abstract：:Vascular permeability and endothelial cell damage has been shown to occur in rats subjected to trauma with hemorrhagic-shock. Although the factors responsible for the endothelial cell injury are unknown, it has been hypothesized that toxic factors produced in response to hemorrhagic-shock originate in the gut and are ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.05.001
更新日期：2005-12-01 00:00:00
abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.08.021
更新日期：2012-11-01 00:00:00
abstract：:We have used high performance liquid chromatography and radioimmunoassay to characterize the CCK-like molecules in the central nervous system. The major form of CCK is the sulfated octapeptide. This molecule is distributed unevenly among various brain regions; the highest levels are found in the cortex and striatum. W...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90015-2
更新日期：1981-01-01 00:00:00
abstract：:Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Dist...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.07.002
更新日期：2003-08-01 00:00:00
abstract：:To investigate the contribution of the N-terminal sequence of h-EGF to its biological activity and the formation of three intramolecular disulfide bonds by oxidative refolding via air oxidation, five derivatives of h-EGF with a single N-terminal amino acid deletion were synthesized by solid-phase synthesis. The homoge...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00181-2
更新日期：1995-01-01 00:00:00
abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90071-9
更新日期：1986-01-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.11.005
更新日期：2012-01-01 00:00:00
abstract：:Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90008-x
更新日期：1980-01-01 00:00:00
abstract：:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00255-3
更新日期：2002-12-01 00:00:00
abstract：:Endothelial neutral endopeptidase (EC 3.4.24.11, NEP) contributes to the inactivation of vasoactive and inflammatory peptides such as f-Met-Leu-Phe, substance P, atrial natriuretic peptide, and bradykinin. The aim of the present study was to investigate the cellular regulation of NEP expression in human endothelial ce...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)00077-w
更新日期：1995-01-01 00:00:00
abstract：:Morphologic and immunohistochemical studies were conducted to ascertain whether pumiliotoxin-B (PTX-B), an indolizine alkaloid from the skin of the Neotropical dendrobatid frog, Dendrobates pumilio, affects the anatomic and immunohistochemical features of the electrically stimulated mouse vas deferens preparations. PT...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00066-2
更新日期：1999-01-01 00:00:00
abstract：:The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90109-9
更新日期：1986-09-01 00:00:00
abstract：:The guinea pig ileum possesses NK-1 and NK-3 tachykinin receptors. As expected, [Pro9]SP and senktide, which are selective agonists of NK-1 and NK-3 receptors, respectively, were found to be highly potent in contracting the guinea pig ileum. Surprisingly, similar observations were made with septide, SP-O-CH3, [Apa9-10...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90125-m
更新日期：1992-03-01 00:00:00
abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00206-l
更新日期：1995-01-01 00:00:00
