Abstract:
:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), MMHir). The peptide evokes a membrane outward current (EC(50) approximately 2 microM), which neither desensitizes nor shows any sign of run-down, and elicits a K(+) conductance increase of the glial cell membrane. The peptidase inhibitor phenylmethylsulfonyl fluoride (PMSF) enhances the glial current response, suggesting the presence of endogenous extracellular peptidases.
journal_name
Peptidesjournal_title
Peptidesauthors
Britz FC,Deitmer JWdoi
10.1016/s0196-9781(02)00255-3subject
Has Abstractpub_date
2002-12-01 00:00:00pages
2117-25issue
12eissn
0196-9781issn
1873-5169pii
S0196978102002553journal_volume
23pub_type
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