Abstract：
:The cervical sympathetic trunk-submandibular gland neuroendocrine axis plays an integral role in physiological adaptations and contributes to the maintenance of systemic homeostasis, particularly under the 'stress conditions' seen with tissue damage, inflammation, and aggressive behavior. The variety of polypeptides, whose release from acinar and ductal cells is under sympathetic nervous system control, offers coordinated and progressive levels of endocrine communication. Proteolytic enzymes (e.g. the kallikreins and furin maturases) are involved in the conversion of inactive precursors (e. g. Pro-EGF and SMR1) into biologically active molecules (e.g. EGF, SMR1-pentapeptide), which act on local or distant targets and thereby modulate the homeostatic process.
journal_name
Peptidesjournal_title
Peptidesauthors
Rougeot C,Rosinski-Chupin I,Mathison R,Rougeon Fdoi
10.1016/s0196-9781(00)00158-3subject
Has Abstractpub_date
2000-03-01 00:00:00pages
443-55issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00158-3journal_volume
21pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract：:The degradation of synthetic Manduca sexta allatostatin (Manse-AS) and allatotropin (Manse-AT), by enzymes of the foregut of larvae of the tomato moth, Lacanobia oleracea was investigated using reversed-phase high performance liquid chromatography (RP-HPLC) together with matrix-assisted laser desorption ionization-tim...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00189-4
更新日期：2002-11-01 00:00:00
abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:In the cephalopod mollusk Octopus vulgaris, the gonadotropic hormone released by the optic gland controls sexual maturity. Several lobes of the central nervous system control the activity of this gland. In one of these lobes, the olfactory lobe, a gonadotropin releasing hormone (GnRH) neuronal system has been describe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.07.007
更新日期：2009-03-01 00:00:00
abstract：:The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.09.010
更新日期：2014-11-01 00:00:00
abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90080-3
更新日期：1983-11-01 00:00:00
abstract：:The peptide IIAEK derived from beta-lactoglobulin has a hypocholesterolemic activity greater than that of beta-sitosterol. To create food proteins with multiple copies of this valuable peptide sequence, we introduced tandem multimers of the nucleotide sequence encoding the peptide into DNA regions corresponding to the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.11.007
更新日期：2006-06-01 00:00:00
abstract：:Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90167-x
更新日期：1982-07-01 00:00:00
abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00122-9
更新日期：1999-01-01 00:00:00
abstract：:The somatostatin analogs D-Phe-Cys-D-Trp-Lys-Thr-Cys-Thr and the corresponding penicillamine compounds have been prepared and tested for their ability to displace [3H]naloxone and [3H] [D-Ala2, D-Leu5]enkephalin from rat brain receptors. While somatostatin and the cystine containing peptide displayed little or no pref...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90026-9
更新日期：1985-01-01 00:00:00
abstract：:The involvement of spinal opioid receptors and spinal monoaminergic systems, in the antinociceptive effect of intrathecal (IT) salmon calcitonin, has been evaluated by means of the hot plate test, in the rat. Intrathecal pretreatment with 40 micrograms MR 1452 and 40 micrograms ICI 154,129, purported selective antagon...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90385-7
更新日期：1985-01-01 00:00:00
abstract：:Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90018-x
更新日期：1985-01-01 00:00:00
abstract：:Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2009.05.002
更新日期：2009-11-01 00:00:00
abstract：:Neuropeptides related to vertebrate tachykinins have been identified in Drosophila and are referred to as drosotachykinins, or DTKs. Two Drosophila G protein-coupled receptors, designated NKD (neurokinin receptor from Drosophila; CG6515) and DTKR (Drosophila tachykinin receptor; CG7887), display sequence similarities ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.10.012
更新日期：2009-03-01 00:00:00
abstract：:Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.005
更新日期：2010-04-01 00:00:00
abstract：:Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.01.016
更新日期：2018-03-01 00:00:00
abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00194-0
更新日期：1997-01-01 00:00:00
abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90097-z
更新日期：1993-07-01 00:00:00
abstract：:The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.024
更新日期：2012-12-01 00:00:00
abstract：:A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed....
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90153-2
更新日期：1988-05-01 00:00:00
abstract：:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.04.010
更新日期：2004-07-01 00:00:00
abstract：:Cocaine- and amphetamine-regulated transcript peptide (CART) with its wide distribution in the brain of mammals has been the focus of considerable research in recent years. Last two decades have witnessed a steady rise in the information on the genes that encode this neuropeptide and regulation of its transcription an...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2014.01.004
更新日期：2014-04-01 00:00:00
abstract：:Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthesized as a precursor (prochemerin) and is proteolytically activated a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.05.030
更新日期：2009-08-01 00:00:00
abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00155-2
更新日期：1999-12-01 00:00:00
abstract：:Binding of [125I]PACAP-38 to rat liver membranes was investigated. It was rapid at 37 degrees C, reversible, and saturable, and it was time, concentration, and temperature dependent. Scatchard plots showed that [125I]PACAP-38 bound to single noninteracting site(s), and [125I]VIP bound to high- and low-affinity binding...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90206-2
更新日期：1994-01-01 00:00:00
abstract：:Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.03.012
更新日期：2015-06-01 00:00:00
abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.01.019
更新日期：2012-03-01 00:00:00
abstract：:This article is the eighteenth installment of our annual review of research concerning the opiate system. It includes articles published during 1995 reporting the behavioral effects of the opiate peptides and antagonists, excluding the purely analgesic effects. The specific topics covered this year include stress: tol...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(96)00225-2
更新日期：1996-01-01 00:00:00
abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90086-9
更新日期：1982-05-01 00:00:00
abstract：:Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00021-6
更新日期：1996-01-01 00:00:00
abstract：:The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90008-0
更新日期：1982-09-01 00:00:00
