Abstract:
:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP2. TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR and RAMP1/2 mRNAs, thereby diminishing AM-evoked cAMP production. The suppression of these three mRNAs was unaffected by inhibiting NOS, protein kinase G, protein kinase A, superoxide formation or NF-kappaB activation.
journal_name
Peptidesjournal_title
Peptidesauthors
Nagoshi Y,Kuwasako K,Cao YN,Imamura T,Kitamura K,Eto Tdoi
10.1016/j.peptides.2004.04.010subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1115-21issue
7eissn
0196-9781issn
1873-5169pii
S0196978104002074journal_volume
25pub_type
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