Receptors for GRP/bombesin-like peptides in the rat forebrain.

abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...

journal_title：Peptides

authors： Philipp E,Wilckens T,Friess E,Platte P,Pirke KM

更新日期：1992-01-01 00:00:00

abstract：:Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...

journal_title：Peptides

authors： Ibii N,Ikeda M,Takahara Y,Eigyo M,Akiyoshi T,Matsushita A

更新日期：1989-07-01 00:00:00

abstract：:The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...

journal_title：Peptides

authors： Lutz TA,Tschudy S,Rushing PA,Scharrer E

更新日期：2000-02-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...

journal_title：Peptides

authors： Radulović J,Dimitrijević M,Laban O,Stanojević S,Vasiljević T,Kovacević-Jovanović V,Marković BM

更新日期：1995-01-01 00:00:00

abstract：:This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...

journal_title：Peptides

authors： Harrold JA,Williams G

更新日期：2006-02-01 00:00:00

abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...

journal_title：Peptides

authors： Hoover DB

更新日期：1991-09-01 00:00:00

abstract：:Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...

journal_title：Peptides

authors： Brauns O,Brauns S,Jenke M,Zimmermann B,Dautzenberg FM

更新日期：2002-10-01 00:00:00

abstract：:Various growth factors and their receptors are present in the nervous system. This review focuses on the presence of epidermal growth factor (EGF) and its receptors in the central nervous system (CNS). Evidence indicates that EGF in the CNS is the result of local synthesis, by intrinsic and blood-derived macrophages, ...

journal_title：Peptides

authors： Plata-Salamán CR

更新日期：1991-05-01 00:00:00

abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...

journal_title：Peptides

authors： Taneja-Bageshwar S,Strey A,Zubrzak P,Williams H,Reyes-Rangel G,Juaristi E,Pietrantonio P,Nachman RJ

更新日期：2008-02-01 00:00:00

abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...

journal_title：Peptides

authors： Morley JE,Levine AS,Gosnell BA,Mitchell JE,Krahn DD,Nizielski SE

更新日期：1985-01-01 00:00:00

abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...

journal_title：Peptides

authors： Bender T,Török I,Barna I,Géher P

更新日期：2001-04-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...

journal_title：Peptides

authors： Lin P,Xia L,Ng TB

更新日期：2007-08-01 00:00:00

abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...

journal_title：Peptides

authors： Palm S,Roman E,Nylander I

更新日期：2012-07-01 00:00:00

abstract：:An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...

journal_title：Peptides

authors： Ling R,Dai Y,Huang B,Huang W,Yu J,Lu X,Jiang Y

更新日期：2020-08-01 00:00:00

abstract：:We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...

journal_title：Peptides

authors： Wanke IE,Huang M,Rorstad OP

更新日期：1990-11-01 00:00:00

abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...

journal_title：Peptides

authors： Kitabgi P,Kwan CY,Fox JE,Vincent JP

更新日期：1984-09-01 00:00:00

abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...

journal_title：Peptides

authors： Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra H

更新日期：2007-10-01 00:00:00

abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...

journal_title：Peptides

authors： Mata X,Renaud G,Mollereau C

更新日期：2019-12-01 00:00:00

abstract：:Chronic administration of neuroleptics has been shown to affect the endogenous levels, mRNA, posttranslational processing, and metabolism of neuropeptides in specific regions of rat brain. Neutral endopeptidase 24.11 (NEP) is known to metabolize a variety of neuropeptide substrates, including the enkephalins and neuro...

journal_title：Peptides

authors： Konkoy CS,Oakes MG,Davis TP

更新日期：1993-09-01 00:00:00

abstract：:D-Amino acid substitutions in the anti-inflammatory/antipyretic Ac-alpha-MSH(11-13)-NH2 tripeptide of Ac-alpha-MSH(1-13)-NH2 were made and the altered peptides were injected in mice treated with picryl chloride. Ear swelling, measured 3 and 6 h after application of the irritant, was reduced by IP injections of Ac-alph...

journal_title：Peptides

authors： Hiltz ME,Catania A,Lipton JM

更新日期：1991-07-01 00:00:00

abstract：:This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers i...

journal_title：Peptides

authors： Chronwall BM,Zukowska Z

更新日期：2004-03-01 00:00:00

abstract：:Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...

journal_title：Peptides

authors： Dosler S,Mataraci E

更新日期：2013-11-01 00:00:00

abstract：:A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...

journal_title：Peptides

authors： Stone SR,Giragossian C,Mierke DF,Jackson GE

更新日期：2007-11-01 00:00:00

abstract：:Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...

journal_title：Peptides

authors： Sato K,Koyama T,Shichiri M

更新日期：2008-12-01 00:00:00

abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...

journal_title：Peptides

authors： Wang S,Lin J,Ye M,Ng TB,Rao P,Ye X

更新日期：2006-12-01 00:00:00

abstract：:The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...

journal_title：Peptides

authors： Santiago JCP,Otto M,Kern W,Baier PC,Hallschmid M

更新日期：2018-04-01 00:00:00

abstract：:Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...

journal_title：Peptides

authors： Zhuo JL,Li XC

更新日期：2011-07-01 00:00:00

abstract：:A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...

journal_title：Peptides

authors： Varas M,Pérez M,Ramírez O,de Barioglio SR

更新日期：2002-01-01 00:00:00

abstract：:This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...

journal_title：Peptides

authors： Tao H,Rui C,Zheng J,Tang J,Wu L,Shi A,Chen N,He R,Wu C,Li J,Yin X,Zhang P,Zhu Z,Tao J,Xiao J,Mao C,Xu Z

更新日期：2013-06-01 00:00:00