Response of exocrine pancreatic secretion to CCK in adrenalectomized rats.


:A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed. The secretion of total protein and amylase decreases significantly after sixth day, reaching the lowest levels after 21 days. Despite this, after 6 days the adrenalectomized rats showed the same capacity of response to CCK as the non-adrenalectomized animals, while after longer periods of time (15 and 21 days) the response to CCK was inhibited. The fact that the lack of glucocorticoids prevents the maturation of zymogen granules seems to be the main reason why the acinar cells do not increase protein secretion in response to CCK at 15 and 21 days after adrenalectomy. It is concluded that the sensitivity of exocrine pancreas to CCK and the amount of zymogen granules in the acinar cells decrease as a function of the time over which the animals are deprived of glucocorticoids.






Manso MA,De Dios I,Garcia AM,Calvo JJ




Has Abstract


1988-05-01 00:00:00
















  • Regulation of hepcidin in HepG2 and RINm5F cells.

    abstract::Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...


    pub_type: 杂志文章


    authors: Fein E,Merle U,Ehehalt R,Herrmann T,Kulaksiz H

    更新日期:2007-05-01 00:00:00

  • Changes of beta-casomorphin content in human milk during lactation.

    abstract::Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...


    pub_type: 杂志文章


    authors: Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra H

    更新日期:2007-10-01 00:00:00

  • Increased acyl ghrelin but decreased total ghrelin and unacyl ghrelin in Chinese Han people with impaired fasting glucose combined with impaired glucose tolerance.

    abstract::We assessed the plasma acyl ghrelin (AG), unacyl ghrelin (UAG), and total ghrelin (TGhr) levels in Chinese adults with pre-diabetes and newly diagnosed diabetes mellitus (NDDM) after an oral glucose tolerance test (OGTT), and abdominal subcutaneous fat area and visceral fat area (VFA) were measured. Fasting AG level w...


    pub_type: 杂志文章


    authors: Huang L,Tong Y,Zhang F,Yang Q,Li D,Xie S,Li Y,Cao H,Tang L,Zhang X,Tong N

    更新日期:2014-10-01 00:00:00

  • Differential sensitivity to neurotensin-induced hypothermia, but not analgesia, in Fischer and Lewis rats.

    abstract::Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...


    pub_type: 杂志文章


    authors: Bauco P,Rompré PP

    更新日期:2003-08-01 00:00:00

  • Synthesis and biological activity of N-terminal-truncated derivatives of human epidermal growth factor (h-EGF).

    abstract::To investigate the contribution of the N-terminal sequence of h-EGF to its biological activity and the formation of three intramolecular disulfide bonds by oxidative refolding via air oxidation, five derivatives of h-EGF with a single N-terminal amino acid deletion were synthesized by solid-phase synthesis. The homoge...


    pub_type: 杂志文章


    authors: Shin SY,Shimizu M,Ohtaki T,Munekata E

    更新日期:1995-01-01 00:00:00

  • Antimicrobial activity of polycationic peptides.

    abstract::The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...


    pub_type: 杂志文章


    authors: Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise G

    更新日期:1999-11-01 00:00:00

  • Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated acid secretion in rats.

    abstract::Neurotensin and somatostatin have both been shown to inhibit gastric acid secretion, but no interaction between these peptides has been demonstrated. To determine whether somatostatin might be a mediator of neurotensin's effect on pentagastrin-stimulated gastric acid secretion, we performed the following three experim...


    pub_type: 杂志文章


    authors: Hammer RA,Ochoa A,Fernandez C,Ertan A,Arimura A

    更新日期:1992-11-01 00:00:00

  • Albuminamide: a novel peptide amide isolated from bovine serum.

    abstract::During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...


    pub_type: 杂志文章


    authors: Takamatsu K,Tatemoto K

    更新日期:1991-03-01 00:00:00

  • Blockade of gastric inhibitory polypeptide (GIP) action as a novel means of countering insulin resistance in the treatment of obesity-diabetes.

    abstract::Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes an...


    pub_type: 杂志文章,评审


    authors: Irwin N,Gault VA,O'Harte FPM,Flatt PR

    更新日期:2020-03-01 00:00:00

  • The diversity and evolution of anuran skin peptides.

    abstract::Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...


    pub_type: 杂志文章,评审


    authors: König E,Bininda-Emonds OR,Shaw C

    更新日期:2015-01-01 00:00:00

  • Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor.

    abstract::We tested the endogenous tripeptide TRH (thyrotropin releasing hormone) ability to bind to MC (melanocortin) receptor subtypes. We discovered that TRH binds to the human MCI receptor expressed in COS cells and to murine B16 melanoma cells with 5790+/-1010 nM and 6370+/-1260 nM Ki's, respectively. TRH did not bind to t...


    pub_type: 杂志文章


    authors: Schiöth HB,Prusis P,Muceniece R,Mutulis F,Mutule I,Wikberg JE

    更新日期:1999-01-01 00:00:00

  • Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium.

    abstract::The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...


    pub_type: 杂志文章


    authors: Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

    更新日期:2004-04-01 00:00:00

  • Induction of high level of specific antibody response to the neutralizing epitope ELDKWA on HIV-1 gp41 by peptide-vaccine.

    abstract::The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...


    pub_type: 杂志文章


    authors: Liao M,Lu Y,Xiao Y,Dierich MP,Chen Y

    更新日期:2000-04-01 00:00:00

  • Species differences in the efficacy of compounds at the nociceptin receptor (ORL1).

    abstract::Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...


    pub_type: 杂志文章


    authors: Burnside JL,Rodriguez L,Toll L

    更新日期:2000-07-01 00:00:00

  • Endothelin-1 induces bronchial myofibroblast differentiation.

    abstract::Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...


    pub_type: 杂志文章


    authors: Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

    更新日期:1997-01-01 00:00:00

  • Immunocytochemical localization of somatostatin in human brain.

    abstract::The distribution of somatostatin (SRIF) was examined in normal human forebrain, using thick vibratome cut sections. The unlabeled antibody enzyme method of immunocytochemistry revealed a widespread distribution of SRIF immunoreactive neurons and fibers throughout the septum, diencephalon and corpus striatum. Within th...


    pub_type: 杂志文章


    authors: Bennett-Clarke CA,Joseph SA

    更新日期:1986-09-01 00:00:00

  • Distribution of neuropeptide Y Y1 and Y2 receptors in the postmortem human heart.

    abstract::In the present study, we present for the first time the presence and distribution of neuropeptide Y (NPY) receptors Y1 and Y2 in the human postmortem heart using specific antibodies raised against extracellular parts of the receptors. A more intensive staining against the Y2 than against the Y1 receptors was detected ...


    pub_type: 杂志文章


    authors: Jönsson-Rylander AC,Nordlander M,Svindland A,Ilebekk A

    更新日期:2003-02-01 00:00:00

  • Discrete mapping of brain Mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptors.

    abstract::The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...


    pub_type: 杂志文章


    authors: Sharif NA,Hughes J

    更新日期:1989-05-01 00:00:00

  • Comparative peptidomics of four related hemipteran species: pyrokinins, myosuppressin, corazonin, adipokinetic hormone, sNPF, and periviscerokinins.

    abstract::We performed the first comprehensive peptidomic analysis of neurohormones from hemipteran insects by analyzing the neuropeptides of two major neurohemal organs, namely the corpora cardiaca and abdominal perisympathetic organs. For the experiments we selected four related species of polyphagous stinkbugs (Pentatomidae)...


    pub_type: 杂志文章


    authors: Predel R,Russell WK,Russell DH,Lopez J,Esquivel J,Nachman RJ

    更新日期:2008-02-01 00:00:00

  • Sequence of small cardioactive peptide A: a second member of a class of neuropeptides in Aplysia.

    abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...


    pub_type: 杂志文章


    authors: Lloyd PE,Kupfermann I,Weiss KR

    更新日期:1987-01-01 00:00:00

  • C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.

    abstract::Endomorphin1-ol (Tyr-Pro-Trp-Phe-ol, EM1-ol) and endomorphin2-ol (Tyr-Pro-Phe-Phe-ol, EM2-ol), with C-terminal alcohol (-ol) containing, have been shown to exhibit higher affinity and lower intrinsic efficacy in vitro than endomorphins. In the present study, in order to investigate the alterations of systemic hemodyna...


    pub_type: 杂志文章


    authors: Yu Y,Wang CL,Cui Y,Fan YZ,Liu J,Shao X,Liu HM,Wang R

    更新日期:2006-01-01 00:00:00

  • Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents.

    abstract::Obestatin is produced in the stomach from proghrelin by post-translational cleavage. The initial report claimed anorexigenic effects of obestatin in mice. Contrasting studies indicated no effect of obestatin on food intake (FI). We investigated influences of metabolic state (fed/fasted), environmental factors (dark/li...


    pub_type: 杂志文章


    authors: Kobelt P,Wisser AS,Stengel A,Goebel M,Bannert N,Gourcerol G,Inhoff T,Noetzel S,Wiedenmann B,Klapp BF,Taché Y,Mönnikes H

    更新日期:2008-06-01 00:00:00

  • The NMDA receptor antagonist, NPC 12626, reduces the pronociceptive effects of orphanin FQ and kappa opiate antinociception in the land snail, Cepaea nemoralis.

    abstract::The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...


    pub_type: 杂志文章


    authors: Kavaliers M,Choleris E,Saucier DM

    更新日期:1997-01-01 00:00:00

  • Different effects of methionine-enkephalin on paw edema in two inbred rat strains.

    abstract::The effect of intraplantarly ( methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta op...


    pub_type: 杂志文章


    authors: Stanojević S,Radulović J,Kovacević-Jovanović V,Vujić V,Dimitrijević M

    更新日期:2002-09-01 00:00:00

  • VIP receptors in mesenteric and coronary arteries: a radioligand binding study.

    abstract::Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...


    pub_type: 杂志文章


    authors: Huang M,Rorstad OP

    更新日期:1987-05-01 00:00:00

  • Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels.

    abstract::On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...


    pub_type: 杂志文章


    authors: Mahjoubi-Boubaker B,Crest M,Khalifa RB,El Ayeb M,Kharrat R

    更新日期:2004-04-01 00:00:00

  • Brain CCKA receptors mediate the colonic motor response to feeding in dogs.

    abstract::The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...


    pub_type: 杂志文章


    authors: Gue M,Bueno L

    更新日期:1991-05-01 00:00:00

  • Immunohistochemical demonstration of [D-Ala2]deltorphin-I in amacrine cells of rat retina.

    abstract::In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...


    pub_type: 杂志文章


    authors: Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

    更新日期:1994-01-01 00:00:00

  • Release of serotonin from RBL-2H3 cells by the Escherichia coli peptide toxin STb.

    abstract::Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...


    pub_type: 杂志文章


    authors: Harville BA,Dreyfus LA

    更新日期:1996-01-01 00:00:00

  • FMRFamide-related peptides in the gut of Locusta migratoria L.: a comprehensive map and developmental profile.

    abstract::The gut tissues and associated nervous system of the African migratory locust, Locusta migratoria, were found to contain FMRFamide-like immunoreactive (FLI) material throughout the five larval instars and 2 weeks into the adult stage in both males and females. FMRFamide-like immunoreactivity associated with the locust...


    pub_type: 杂志文章


    authors: Hill SR,Orchard I

    更新日期:2003-10-01 00:00:00