Response of exocrine pancreatic secretion to CCK in adrenalectomized rats.

abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...

journal_title：Peptides

authors： Ivars J,Butruille L,Knauf C,Bouckenooghe T,Mayeur S,Vieau D,Valet P,Deruelle P,Lesage J

更新日期：2012-05-01 00:00:00

abstract：:This study aimed to examine the effects of CPB on salusin-α, salusin-β and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. T...

journal_title：Peptides

authors： Aydin S,Eren MN,Aydin S,Ozercan IH,Dagli AF

更新日期：2012-10-01 00:00:00

abstract：:In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...

journal_title：Peptides

authors： Hernández F,Catalán RE,Martinez AM

更新日期：1999-01-01 00:00:00

abstract：:The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...

journal_title：Peptides

authors： Denbow DM

更新日期：1989-03-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...

journal_title：Peptides

authors： Romerio SC,Linder L,Flammer J,Haefeli WE

更新日期：2000-06-01 00:00:00

abstract：:ZP120 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) ligand. In previous studies, the effects of ZP120 were found to be sensitive to J-113397 in mouse tissues while resistant to UFP-101 in rat tissues. The aim of this study was to further investigate the ZP120 pharmacological profile using mouse and rat pr...

journal_title：Peptides

authors： Fischetti C,Rizzi A,Gavioli EC,Marzola G,Trapella C,Guerrini R,Petersen JS,Calo G

更新日期：2009-02-01 00:00:00

abstract：:Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...

journal_title：Peptides

authors： Chi AL,Lim S,Wang TC

更新日期：2004-05-01 00:00:00

abstract：:Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...

journal_title：Peptides

authors： Görcs TJ,Gottschall PE,Coy DH,Arimura A

更新日期：1986-11-01 00:00:00

abstract：:A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known proteins and peptides and a molecular mass of 8kDa, was isolated from seeds of the green chickpea Cicer arietinum cv green chickpea. Cicerarin was isolated with a procedure that involved ion exchange chrom...

journal_title：Peptides

authors： Chu KT,Liu KH,Ng TB

更新日期：2003-05-01 00:00:00

abstract：:We recently discovered that vascular responsiveness to adrenomedullin (AM), a vasoactive hormone, decreases after hemorrhage, which is markedly improved by the addition of its binding protein AMBP-1. One obstacle hampering the development of AM/AMBP-1 as resuscitation agents in trauma victims is the potential immunoge...

journal_title：Peptides

authors： Wu R,Dong W,Qiang X,Ji Y,Cui T,Yang J,Zhou M,Blau S,Marini CP,Ravikumar TS,Wang P

更新日期：2008-07-01 00:00:00

abstract：:Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY signi...

journal_title：Peptides

authors： Klemp K,Woldbye DP

更新日期：2001-03-01 00:00:00

abstract：:Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...

journal_title：Peptides

authors： Heidbreder C,Gewiss M,De Mot B,Mertens I,De Witte P

更新日期：1992-05-01 00:00:00

abstract：:Studies were conducted in order to determine if selected neurons could be isolated from the brain using Sepharose-linked recognition complexes directed against or related to the biosynthetic/neurosecretory product of the desired neuronal population. Immunoreactive LRF neurons were precipitated when dispersed cells of ...

journal_title：Peptides

authors： Melrose PA,Knigge KM

更新日期：1985-03-01 00:00:00

abstract：:Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and ...

journal_title：Peptides

authors： Deschodt-Lanckman M,Koulischer D,Przedborski S,Lauwereys M

更新日期：1984-05-01 00:00:00

abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...

journal_title：Peptides

authors： Cabot C,Grasa MM,Adán C,Pérez-Clausell J,Virgili J,Estruch J,Fernández-Löpez JA,Remesar X,Alemany M

更新日期：1998-01-01 00:00:00

abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...

journal_title：Peptides

authors： Wheway J,Herzog H,Mackay F

更新日期：2007-02-01 00:00:00

abstract：:The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...

journal_title：Peptides

authors： Moss RB,Golightly MG

更新日期：1991-07-01 00:00:00

abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...

journal_title：Peptides

authors： Howl J,Howl L,Jones S

更新日期：2018-03-01 00:00:00

abstract：:The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...

journal_title：Peptides

authors： Pournajafi-Nazarloo H,Kenkel W,Mohsenpour SR,Sanzenbacher L,Saadat H,Partoo L,Yee J,Azizi F,Carter CS

更新日期：2013-05-01 00:00:00

abstract：:It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...

journal_title：Peptides

authors： Ku YH,Chang YZ

更新日期：2001-09-01 00:00:00

abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...

journal_title：Peptides

authors： Zetler G

更新日期：1985-01-01 00:00:00

abstract：:Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...

journal_title：Peptides

authors： Inoue H,Ohira T,Nagasawa H

更新日期：2007-03-01 00:00:00

abstract：:The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...

journal_title：Peptides

authors： Xinan L,Suguang L,Liangchao Z,Lei C

更新日期：1998-01-01 00:00:00

abstract：:Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

journal_title：Peptides

authors： Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

更新日期：2001-10-01 00:00:00

abstract：:Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...

journal_title：Peptides

authors： Tölle M,van der Giet M

更新日期：2008-05-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...

journal_title：Peptides

authors： Kinhult J,Egesten A,Uddman R,Cardell LO

更新日期：2002-10-01 00:00:00

abstract：:A new CCK8 related peptide, Boc[Nle28,Nle31]CCK27-33 (Boc[diNle]CCK7) was synthesized and tested for cholecystokinic activity, at both the peripheral and the central level. This analogue, protected against both chemical oxidation and enzymatic degradation by aminopeptidases, was shown to be equipotent to CCK8 in relea...

journal_title：Peptides

authors： Ruiz-Gayo M,Daugé V,Menant I,Bégué D,Gacel G,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...

journal_title：Peptides

authors： Kastin AJ,Akerstrom V,Pan W

更新日期：2001-12-01 00:00:00