The substance P/neurokinin-1 receptor system in lung cancer: focus on the antitumor action of neurokinin-1 receptor antagonists.

abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...

journal_title：Peptides

authors： Bender T,Török I,Barna I,Géher P

更新日期：2001-04-01 00:00:00

abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...

journal_title：Peptides

authors： Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin G

更新日期：1984-03-01 00:00:00

abstract：:The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...

journal_title：Peptides

authors： Flanagan-Cato LM,Moga CN,Fluharty SJ

更新日期：1996-01-01 00:00:00

abstract：:Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...

journal_title：Peptides

authors： Sciani JM,Sampaio MC,Zychar BC,Gonçalves LR,Giorgi R,Nogueira Tde O,de Melo RL,Teixeira Cde F,Pimenta DC

更新日期：2014-03-01 00:00:00

abstract：:Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they are considered an important public health threat. In order to identify some of their naturally occurring toxin peptides available in very low amounts, we combine analytical protocols suc...

journal_title：Peptides

authors： Conceição K,Santos JM,Bruni FM,Klitzke CF,Marques EE,Borges MH,Melo RL,Fernandez JH,Lopes-Ferreira M

更新日期：2009-12-01 00:00:00

abstract：:The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulat...

journal_title：Peptides

authors： Cronin MJ,Zysk JR,Baertschi AJ

更新日期：1986-09-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...

journal_title：Peptides

authors： Mata X,Renaud G,Mollereau C

更新日期：2019-12-01 00:00:00

abstract：:ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic rece...

journal_title：Peptides

authors： Tonnaer JA,Van Vugt M,De Graaf JS

更新日期：1986-05-01 00:00:00

abstract：:We performed the first comprehensive peptidomic analysis of neurohormones from hemipteran insects by analyzing the neuropeptides of two major neurohemal organs, namely the corpora cardiaca and abdominal perisympathetic organs. For the experiments we selected four related species of polyphagous stinkbugs (Pentatomidae)...

journal_title：Peptides

authors： Predel R,Russell WK,Russell DH,Lopez J,Esquivel J,Nachman RJ

更新日期：2008-02-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...

journal_title：Peptides

authors： Kantyka T,Fischer J,Wu Z,Declercq W,Reiss K,Schröder JM,Meyer-Hoffert U

更新日期：2011-06-01 00:00:00

abstract：:We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...

journal_title：Peptides

authors： Fukuhara S,Mukai H,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...

journal_title：Peptides

authors： Tsutsui C,Kajihara K,Yanaka T,Sakata I,Itoh Z,Oda S,Sakai T

更新日期：2009-02-01 00:00:00

abstract：:Opioid receptor analyses of deltorphin A (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogues indicated the following: (a) increased negativity differentially affected affinities (Ki) and selectivity (Ki mu/Ki delta); (b) shifted sequence heptapeptides, [Asp5,Leu6,Met-NH2(7)] and [Asp4,His5,Leu6,Met-NH2(7)], reversed selec...

journal_title：Peptides

authors： Lazarus LH,Salvadori S,Attila M,Grieco P,Bundy DM,Wilson WE,Tomatis R

更新日期：1993-01-01 00:00:00

abstract：:The proteolytic conversion of oxytocin and vasopressin by purified rat brain synaptic membranes was studied at 37 degrees C and physiological pH 7.4. The formed peptide fragments were isolated by high performance liquid chromatography and characterized by amino acid analysis. When oxytocin was incubated with synaptic ...

journal_title：Peptides

authors： Stancampiano R,Melis MR,Argiolas A

更新日期：1991-09-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...

journal_title：Peptides

authors： Altstein M

更新日期：2004-09-01 00:00:00

abstract：:This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...

journal_title：Peptides

authors： Rao KR,Riehm JP

更新日期：1988-01-01 00:00:00

abstract：:Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperp...

journal_title：Peptides

authors： Polidori C,de Caro G,Massi M

更新日期：2000-07-01 00:00:00

abstract：:We have used high performance liquid chromatography and radioimmunoassay to characterize the CCK-like molecules in the central nervous system. The major form of CCK is the sulfated octapeptide. This molecule is distributed unevenly among various brain regions; the highest levels are found in the cortex and striatum. W...

journal_title：Peptides

authors： Beinfeld MC,Meyer DK,Brownstein MJ

更新日期：1981-01-01 00:00:00

abstract：:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...

journal_title：Peptides

authors： Reymann KG,Chepkova AN,Matthies H

更新日期：1983-05-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00

abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...

journal_title：Peptides

authors： Betourne A,Marty V,Ceccom J,Halley H,Lassalle JM,Zajac JM,Frances B,Mouledous L

更新日期：2010-02-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...

journal_title：Peptides

authors： Cabot C,Grasa MM,Adán C,Pérez-Clausell J,Virgili J,Estruch J,Fernández-Löpez JA,Remesar X,Alemany M

更新日期：1998-01-01 00:00:00

abstract：:Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...

journal_title：Peptides

authors： Resende JM,Moraes CM,Prates MV,Cesar A,Almeida FC,Mundim NC,Valente AP,Bemquerer MP,Piló-Veloso D,Bechinger B

更新日期：2008-10-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...

journal_title：Peptides

authors： Tao H,Rui C,Zheng J,Tang J,Wu L,Shi A,Chen N,He R,Wu C,Li J,Yin X,Zhang P,Zhu Z,Tao J,Xiao J,Mao C,Xu Z

更新日期：2013-06-01 00:00:00

abstract：:Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...

journal_title：Peptides

authors： Nongonierma AB,Fitzgerald RJ

更新日期：2012-10-01 00:00:00

abstract：:The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...

journal_title：Peptides

authors： Kavaliers M,Choleris E,Saucier DM

更新日期：1997-01-01 00:00:00