Abstract:
:The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulators of protein kinase C. This effect occurred within minutes, was concentration dependent, and exhibited the appropriate pharmacological specificity to attribute the effects to protein kinase C. Phorbol myristate acetate (PMA), phorbol dibutyrate (PDB) and teleocidin were active with appropriate EC50's, while 4-alpha-PMA was inactive. PMA and PDB were also ACTH secretagogues in their own right. We suggest that protein kinase C can modulate CRF receptor coupling to the adenylate cyclase holoenzyme in anterior pituitary cells.
journal_name
Peptidesjournal_title
Peptidesauthors
Cronin MJ,Zysk JR,Baertschi AJdoi
10.1016/0196-9781(86)90114-2subject
Has Abstractpub_date
1986-09-01 00:00:00pages
935-8issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(86)90114-2journal_volume
7pub_type
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