Abstract：
:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in circumventricular organs. Numerous immunoreactive cells were found covering the walls of the lateral ventricles in the telencephalon, as well as in the diencephalic and mesencephalic ventricles. In the hypothalamus, both the preoptic nucleus and the infundibular region showed numerous immunopositive cells. Ependymal cells lining the rhomboencephalic fourth ventricle and the central canal of the spinal cord were also immunoreactive. The concentration of endozepine-like immunoreactivity was measured in various regions of the brain using a sensitive and specific radioimmunoassay for rat ODN. The highest levels of ODN-like immunoreactivity were found in the infundibulum, cerebellum and preoptic area. Reverse phase high performance liquid chromatography and radioimmunoassay quantification were used to characterize endozepines in the frog brain. The elution profiles of the different brain regions revealed four major immunoreactive peaks. The present results demonstrate the presence of peptides immunologically related to the endozepine family in the central nervous system of the frog. The localization of immunoreactive endozepines in ependymal cells suggests that these peptides play important neuromodulatory functions in the amphibian brain.
journal_name
Peptidesjournal_title
Peptidesauthors
Malagon M,Vaudry H,Vallarino M,Gracia-Navarro F,Tonon MCdoi
10.1016/0196-9781(92)90146-tsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
99-107issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(92)90146-Tjournal_volume
13pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 microgram/kg IP and 0.5-5.0 microgram/IVT, indicating a peripheral mechanism in ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90066-8
更新日期：1981-01-01 00:00:00
abstract：:Nociceptin/orphanin FQ (NC), the endogenous ligand of the opioid receptor-like1 (ORL1) receptor, has been reported to stimulate feeding in rats. The present article reviews the studies so far published on the effect of NC on food intake and reports new findings concerning the sensitivity of brain regions to the hyperp...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00243-6
更新日期：2000-07-01 00:00:00
abstract：:Urotensin II (UII), first identified from goby urophysis, is a potent vasoactive peptide hormone and an endogenous ligand for an orphan G protein-coupled receptor GPR14, now named urotensin II receptor (UT-R). In addition to its vascular actions, UII has been shown to have mitogenic effects on tumor growth and some re...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.06.025
更新日期：2008-05-01 00:00:00
abstract：:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.06.006
更新日期：2005-12-01 00:00:00
abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90165-2
更新日期：1990-11-01 00:00:00
abstract：:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00421-1
更新日期：2001-07-01 00:00:00
abstract：:We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00416-8
更新日期：2001-06-01 00:00:00
abstract：:The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.04.020
更新日期：2011-06-01 00:00:00
abstract：:Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.005
更新日期：2010-04-01 00:00:00
abstract：:Neuropeptide Y (NPY) induces feeding in previously satiated animals after injection into the hypothalamus, especially the perifornical region (PFH). NPY also appears to have rewarding properties as evidenced by its ability to produce a conditioned place preference following injection into the nucleus accumbens (N.Acc)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00117-x
更新日期：1998-01-01 00:00:00
abstract：:Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90113-7
更新日期：1989-07-01 00:00:00
abstract：:Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90220-3
更新日期：1988-01-01 00:00:00
abstract：:Evidence on the relative roles of endothelin ET(A) and ET(B) receptors in mediating the nociceptive and hyperalgesic actions of endothelin-1 is still fragmented and conflicting, due to variations between species and/or models. This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.011
更新日期：2009-05-01 00:00:00
abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80126-x
更新日期：1981-10-01 00:00:00
abstract：:Smooth muscle cells isolated by enzymatic digestion were used to determine the direct effects of galanin on circular and longitudinal muscle layers from dog proximal colon and to investigate the intracellular pathways involved in these effects. Effects of galanin were compared to those observed with other contracting ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90088-4
更新日期：1994-01-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs are positively charged, mucins negatively. It was the aim of the study to test whether these opposite charges result in interactions between AMPs and mucins. We measur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.07.018
更新日期：2006-12-01 00:00:00
abstract：:Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90099-o
更新日期：1992-03-01 00:00:00
abstract：:Angiotensin II binding sites were localized and quantified in individual brain nuclei from single rats by incubation of tissue sections with 1 nM 125I-[Sar1]-angiotensin II, [3H]-Ultrofilm autoradiography, computerized microdensitometry and comparison with 125I-standards. High angiotensin II binding was present in the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90044-6
更新日期：1986-07-01 00:00:00
abstract：:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00070-8
更新日期：1996-01-01 00:00:00
abstract：:The present studies were undertaken to better characterize the pharmacological properties of oxytocin receptors (OTRs) of the porcine kidney cell line, LLC-PK1, in their natural membranous environment and after solubilization. In intact membranes, binding of a selective radioligand was rapid, reversible, saturable, an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02121-3
更新日期：1996-01-01 00:00:00
abstract：:The Y5 receptor has been postulated to be the main receptor mediating NPY-induced food intake in rats, based on its pharmacological profile and mRNA distribution. To further characterize this important receptor subtype, we isolated the Y5 gene in the guinea pig, a widely used laboratory animal in which all other known...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00338-2
更新日期：2001-03-01 00:00:00
abstract：:The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90158-d
更新日期：1993-05-01 00:00:00
abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90047-s
更新日期：1991-09-01 00:00:00
abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(81)90004-8
更新日期：1981-01-01 00:00:00
abstract：:Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(01)00508-3
更新日期：2001-11-01 00:00:00
abstract：:The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.09.010
更新日期：2014-11-01 00:00:00
abstract：:The aims of these studies were to determine the precise molecular nature of immunoreactive (IR-) vasopressin (AVP) in the ovine hypothalamo-pituitary axis and to examine a possible role for glucocorticoids in regulating both AVP processing and levels in this axis. The IR-AVP in extracts of paraventricular nucleus, med...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90119-2
更新日期：1993-07-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) has a similar structure to that of vasoactive intestinal peptide (VIP) and both the polypeptides belong to the same molecular group, the secretin-glucagon superfamily. PACAP and VIP have possible potency as hypothalamic factors mediating the release of pituita...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.02.022
更新日期：2005-09-01 00:00:00
