Abstract：
:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, Leu(13) psi(CH2NH)-Leu14] bombesin (6-14) (RC-3095) (0.2, 1.0 or 5.0mg/kg) 30 min before exposure to an open field or an elevated plus maze. Habituation to the open field was tested in a retention trial carried out 24 h after the first exposure to the open field. Rats given RC-3095 at the doses of 1.0 or 5.0mg/kg showed impaired habituation. Animals treated with 5.0mg/kg of RC-3095 spent significantly more time in the closed arms of the elevated plus maze. No effects of RC-3095 on locomotion or exploratory behavior were observed. The results implicate the GRPR in the regulation of non-emotional, non-associative memory as well as in anxiety.
journal_name
Peptidesjournal_title
Peptidesauthors
Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler Rdoi
10.1016/j.peptides.2005.06.006subject
Has Abstractpub_date
2005-12-01 00:00:00pages
2525-9issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00302-5journal_volume
26pub_type
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