Abstract:
:Numerous substance P (SP) immunoreactive nerve fibers were located around submucosal glands in the guinea pig nasal mucosa. Since these SP positive nerve fibers were also positive for vasoactive intestinal polypeptide, and to a lessor extent for neuropeptide Y, they were presumed to be parasympathetic fibers. SP receptor positive structures were observed exclusively on the membrane of myoepithelial cells in normal nasal mucosa, suggesting that myoepithelial cells are targets of SP positive fibers. SP receptor-like immunoreactivity was observed associated with intracellular organella of myoepithelial cells 5 min after intranasal histamine challenge, which may indicate the molecular basis for histamine-induced nasal discharge.
journal_name
Peptidesjournal_title
Peptidesauthors
Shibano A,Kawai Y,Senba Edoi
10.1016/s0196-9781(98)00100-4subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1365-71issue
8eissn
0196-9781issn
1873-5169pii
S0196-9781(98)00100-4journal_volume
19pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90031-j
更新日期:1991-03-01 00:00:00
abstract::The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80003-4
更新日期:1981-04-01 00:00:00
abstract::Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2017.11.016
更新日期:2018-02-01 00:00:00
abstract::Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.006
更新日期:2009-02-01 00:00:00
abstract::High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90090-6
更新日期:1994-01-01 00:00:00
abstract::The role of the D-Trp residues in the sequence of the NK2-selective tachykinin antagonist, MEN 10207 (Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Arg-NH2). has been examined by replacement of each D-Trp with either the L-isomer or the residue naturally occurring in the same position of neurokinin A(4-10). The biological activity of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90053-r
更新日期:1991-09-01 00:00:00
abstract::The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90149-b
更新日期:1993-05-01 00:00:00
abstract::Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed by gut mucus cells. Using specific antisera we have quantified and characterized the molecular forms and distribution of these peptides in the rat gut. SP predominates in the gastric antrum as a 12 kDa form. ITF (7 kDa) is ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00070-z
更新日期:1995-01-01 00:00:00
abstract::Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of micro-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K(+) conductance, inhibition of high-voltage-activated Ca(2+) channel currents, and impediment of neurotransmitter release. Differences in ORL(1) and micro-receptor distributio...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(00)00235-7
更新日期:2000-07-01 00:00:00
abstract::In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.008
更新日期:2005-04-01 00:00:00
abstract::VIP was given intravenously over 1 min at the doses 0.1 and 0.2 micrograms X kg X min-1 to twenty-one anesthetized patients undergoing abdominal surgery. Intra-arterial blood pressure was monitored and various blood flows were measured simultaneously by electromagnetic technique. Following VIP, intra-arterial blood pr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90227-4
更新日期:1984-03-01 00:00:00
abstract::Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.007
更新日期:2018-03-01 00:00:00
abstract::Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.009
更新日期:2011-06-01 00:00:00
abstract::A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90168-o
更新日期:1991-01-01 00:00:00
abstract::The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance re...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00214-q
更新日期:1995-01-01 00:00:00
abstract::The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.05.004
更新日期:2018-07-01 00:00:00
abstract::This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90013-7
更新日期:1993-01-01 00:00:00
abstract::Obestatin is produced in the stomach from proghrelin by post-translational cleavage. The initial report claimed anorexigenic effects of obestatin in mice. Contrasting studies indicated no effect of obestatin on food intake (FI). We investigated influences of metabolic state (fed/fasted), environmental factors (dark/li...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.020
更新日期:2008-06-01 00:00:00
abstract::Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00044-5
更新日期:2003-02-01 00:00:00
abstract::The teleost salmon calcitonin (sCT), but not mammalian CT, shows similar biologic actions in the skeletal muscle as amylin and calcitonin gene-related peptide (CGRP). The peptides have also been shown to reduce food intake in rams. Because sCT, but not amylin, binds irreversibly to amylin binding sites, the aim of the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00208-9
更新日期:2000-02-01 00:00:00
abstract::This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.07.022
更新日期:2009-03-01 00:00:00
abstract::We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P<0.01) in blood pressure, heart rate, endo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.001
更新日期:2005-12-01 00:00:00
abstract::We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02047-0
更新日期:1995-01-01 00:00:00
abstract::Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90005-3
更新日期:1989-11-01 00:00:00
abstract::The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90065-3
更新日期:1986-01-01 00:00:00
abstract::C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.10.022
更新日期:2008-01-01 00:00:00
abstract::We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90219-5
更新日期:1984-03-01 00:00:00
abstract::Echinometra lucunter is an abundant sea urchin found in Brazilian waters. Accidents caused by this animal are common and are characterized by the penetration of the spines in the skin, which raises an inflammatory reaction through mechanical trauma as well as by the presumable action of toxins. Additionally, there hav...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.07.031
更新日期:2014-03-01 00:00:00
abstract::A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00097-2
更新日期:1999-01-01 00:00:00
abstract::The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.09.010
更新日期:2014-11-01 00:00:00