Abstract:
:This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebrain, hypothalamus, midline and intralaminar thalamus, habenula, periaqueductal gray, locus coeruleus, parabrachial nucleus, medullary raphe and reticular nuclei, and nucleus tractus solitarius. Dual immunocytochemistry was used to identify corticotropin-releasing factor, neurotensin, and enkephalin neurons in DRN terminal fields, in some cases in close proximity to PHA-L-IR terminals. Terminal fields were identified in regions that influence nociception, and the neuroactive substances identified in these terminal fields may play modulatory roles in nociception.
journal_name
Peptidesjournal_title
Peptidesauthors
Sim LJ,Joseph SAdoi
10.1016/0196-9781(93)90013-7subject
Has Abstractpub_date
1993-01-01 00:00:00pages
75-83issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(93)90013-7journal_volume
14pub_type
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