Abstract:
:Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and a minor one at the Tyr27-Met28 bond were identified in the sequence of CCK-8. Replacements of the Met28 and Met31 residues by Thr and either Leu or Nle respectively, in CCK-9 analogues, did not improve the resistance of these peptides to enzymatic degradation. The regional distribution in rat brain of this CCK-8 cleaving endopeptidase displayed marked variations with the highest activity in striatal membranes; it closely followed that described for "enkephalinase" in mouse brain.
journal_name
Peptidesjournal_title
Peptidesauthors
Deschodt-Lanckman M,Koulischer D,Przedborski S,Lauwereys Mdoi
10.1016/0196-9781(84)90098-6subject
Has Abstractpub_date
1984-05-01 00:00:00pages
649-51issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(84)90098-6journal_volume
5pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.022
更新日期:2004-05-01 00:00:00
abstract::Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00149-3
更新日期:2002-10-01 00:00:00
abstract::This work showed the effect of pheromone plantaricin A (PlnA) on the proliferation and migration of the human keratinocytes NCTC 2544. PlnA was chemically synthesized and used as pure peptide or biologically synthesized during co-cultivation of Lactobacillus plantarum DC400 and Lactobacillus sanfranciscensis DPPMA174....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.07.004
更新日期:2011-09-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.05.002
更新日期:2009-11-01 00:00:00
abstract::To determine whether a sex difference exists in the biosynthetic capacity of vasopressingergic (AVP) neurons in the bed nucleus of the stria terminalis (BNST), we have used in situ hybridization and quantitative autoradiography to measure propressophysin messenger RNA levels in these cells from adult male and female r...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90152-6
更新日期:1989-05-01 00:00:00
abstract::Two cDNAs, size 969 bp and 1146 bp respectively, encoding goldfish gamma-preprotachykinin (gamma-PPT) were identified. Both cDNAs contain the same 345 bp open reading frame. The deduced 114-amino acid gamma-PPT contains the sequence of substance P, carassin and neurokinin A. sequence analysis of the two cDNA 5'-untran...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00013-2
更新日期:1997-01-01 00:00:00
abstract::Imidazole-related dipeptides, such as carnosine and anserine, occur widely in skeletal muscles of jawed vertebrates. All of the known enzymes that catalyze the hydrolysis of these dipeptides belong to the M20A metallopeptidase subfamily; two secretory enzymes, serum carnosinase (EC 3.4.13.20) and anserinase (EC 3.4.13...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.01.008
更新日期:2011-04-01 00:00:00
abstract::Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00335-x
更新日期:1997-01-01 00:00:00
abstract::This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.07.022
更新日期:2009-03-01 00:00:00
abstract::We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90083-9
更新日期:1983-11-01 00:00:00
abstract::The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(88)90098-8
更新日期:1988-09-01 00:00:00
abstract::In non-pregnant goats, ovariectomy on day 12 of oestrous cycle resulted in parallel decrease of oxytocin and progesterone jugular concentration. Similarly, luteolysis, indicated by decreasing progesterone concentration, was accompanied by simultaneous release of oxytocin and oxytocin-associated neurophysins (mean of n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90063-5
更新日期:1987-09-01 00:00:00
abstract::This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90013-7
更新日期:1993-01-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00
abstract::Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2007.08.029
更新日期:2008-05-01 00:00:00
abstract::We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.03.009
更新日期:2014-06-01 00:00:00
abstract::The present study sought to examine the mechanism of substance P to modulate the antinociceptive action of intrathecal (i.t.) morphine in paw-licking/biting response evoked by subcutaneous injection of capsaicin into the plantar surface of the hindpaw in mice. The i.t. injection of morphine inhibited capsaicin-induced...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.002
更新日期:2009-09-01 00:00:00
abstract::Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.025
更新日期:2006-03-01 00:00:00
abstract::We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghreli...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.03.021
更新日期:2010-06-01 00:00:00
abstract::Urocortin (Ucn) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related peptides recently characterized in mammals. Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands. They also have a distinct pattern of distribution, both in the ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.05.025
更新日期:2004-10-01 00:00:00
abstract::Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.016
更新日期:2018-03-01 00:00:00
abstract::The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170443
更新日期:2020-11-07 00:00:00
abstract::We studied the expression of the osteogenic and antinociceptive C-terminal histone H4-related peptide fragments, H4-(89-102) (OGP) and H4-(86-100), respectively, within various rat tissues and isolated alveolar macrophages (AM) by radioimmunoassay (RIA). OGP was located mainly within the bone marrow, spleen, thymus, a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.03.013
更新日期:2005-08-01 00:00:00
abstract::The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.024
更新日期:2012-12-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.019
更新日期:2008-11-01 00:00:00
abstract::Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.07.028
更新日期:2009-12-01 00:00:00
abstract::As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90046-2
更新日期:1981-01-01 00:00:00
abstract::Amyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived pepti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00058-x
更新日期:2002-07-01 00:00:00
abstract::Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00137-4
更新日期:1996-01-01 00:00:00