Abstract：
:We have previously shown that ghrelin is mainly localized to the stomach but also occurs, together with the prokinetic hormone motilin, in endocrine cells in the proximal small intestine. This study explored ghrelin and motilin concentrations in plasma in relation to gastrointestinal motility and whether plasma ghrelin is changed in patients with irritable bowel syndrome (IBS). Nine patients with severe IBS and 10 healthy subjects underwent stationary antro-duodeni-jejunal manometry; blood was sampled during similar motility phases in the two groups. The motility phases were monitored and blood samples were collected during fasting and after food intake. Plasma was analyzed for two forms of ghrelin (octanylated and desoctanylated) as well as for motilin. In IBS patients circulating motilin levels covaried with total ghrelin levels (r=0.90; p<0.004), octanylated ghrelin (r=0.77; p<0.02) and desoctanylated ghrelin (r=0.69; p<0.04). No such correlations were seen in the control group. Octanylated ghrelin comprised 35.3+/-3.9% (mean+/-SEM) of the total circulating ghrelin in the IBS patients compared to 40.4+/-4.5% (mean+/-SEM) in the control group (NS). Ghrelin covaried with motilin in plasma in IBS but not in plasma from healthy subjects. This suggests the two peptides act together in IBS.
journal_name
Peptidesjournal_title
Peptidesauthors
Sjölund K,Ekman R,Wierup Ndoi
10.1016/j.peptides.2010.03.021subject
Has Abstractpub_date
2010-06-01 00:00:00pages
1109-12issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00120-8journal_volume
31pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90120-9
更新日期：1988-07-01 00:00:00
abstract：:Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.06.022
更新日期：2008-10-01 00:00:00
abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.03.028
更新日期：2015-09-01 00:00:00
abstract：:In the present review we reevaluated the experimental and clinical evidence that there is a local renin angiotensin system in the heart as well as the presence of a functional intracrine component which is activated during pathological conditions like heart failure and hypertension. The implications of these findings ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2011.06.018
更新日期：2011-08-01 00:00:00
abstract：:Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inh...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00281-4
更新日期：2003-01-01 00:00:00
abstract：:Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90138-7
更新日期：1993-05-01 00:00:00
abstract：:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.04.027
更新日期：2006-10-01 00:00:00
abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90200-7
更新日期：1986-01-01 00:00:00
abstract：:The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90126-0
更新日期：1994-01-01 00:00:00
abstract：:The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90055-8
更新日期：1994-01-01 00:00:00
abstract：:Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.04.003
更新日期：2014-03-01 00:00:00
abstract：:The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.02.007
更新日期：2013-05-01 00:00:00
abstract：:In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00108-4
更新日期：1999-01-01 00:00:00
abstract：:alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80026-5
更新日期：1981-07-01 00:00:00
abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90149-b
更新日期：1993-05-01 00:00:00
abstract：:Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.06.025
更新日期：2006-03-01 00:00:00
abstract：:Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 microgram/kg IP and 0.5-5.0 microgram/IVT, indicating a peripheral mechanism in ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90066-8
更新日期：1981-01-01 00:00:00
abstract：:To characterize the endothelin (ET) receptor that mediates the contraction induced by ET-1 in the porcine myometrium, we carried out a contraction study, radioligand binding study and molecular study (reverse transcription polymerase chain reaction) for detection of ET receptor-coding genes (mRNA). ET-1 (1 nM-1 microM...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00169-8
更新日期：2000-04-01 00:00:00
abstract：:Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression anal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00195-9
更新日期：2000-05-01 00:00:00
abstract：:A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00591-5
更新日期：2002-01-01 00:00:00
abstract：:Amylin is a peptide hormone secreted from the beta cells of the pancreatic islets. Amylin was administered peripherally or centrally following weak or strong training on footshock avoidance conditioning in a T-maze. Under conditions of weak training, amylin improved memory retention in a dose-dependent manner. Under c...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90092-h
更新日期：1992-05-01 00:00:00
abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90425-5
更新日期：1985-11-01 00:00:00
abstract：:Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.03.012
更新日期：2015-06-01 00:00:00
abstract：:Plasmodium falciparum malaria parasite invasion of erythrocytes is an essential step in host infection and the proteins involved in such invasion are the main target in developing an antimalarial vaccine. Secretory organelle-derived proteins (micronemal AMA1 protein and the RON2, 4, and 5 rhoptry neck proteins) have b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.028
更新日期：2014-03-01 00:00:00
abstract：:Pituitary cells from 14-day-old rats were separated by unit gravity velocity sedimentation, and a highly enriched population of gonadotrophs was established in reaggregate cell culture in serum-free and serum albumin-free defined culture media. The medium conditioned by these aggregates was concentrated, ultrafiltrate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90217-8
更新日期：1994-01-01 00:00:00
abstract：:The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90188-u
更新日期：1991-01-01 00:00:00
abstract：:Urotensin-II (U-II), a cyclic peptide widely expressed in blood vessels, has diverse vascular actions that range from potent vasoconstriction to vasodilation. Although, U-II-induced vasodilation has been shown to be partially dependent on nitric oxide (NO), the involvement of vascular adventitia-derived NO, remains un...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.07.006
更新日期：2004-11-01 00:00:00
abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80126-x
更新日期：1981-10-01 00:00:00
abstract：:The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.04.021
更新日期：2005-11-01 00:00:00
abstract：:Imidazole-related dipeptides, such as carnosine and anserine, occur widely in skeletal muscles of jawed vertebrates. All of the known enzymes that catalyze the hydrolysis of these dipeptides belong to the M20A metallopeptidase subfamily; two secretory enzymes, serum carnosinase (EC 3.4.13.20) and anserinase (EC 3.4.13...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.01.008
更新日期：2011-04-01 00:00:00
