Endothelin enhances adenosine and isoprenaline elevated cyclic AMP levels in rat cerebellar slices.

abstract：:The anorectic effect of IP injection of amylin (1 microgram/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 micrograms/kg]. The IP injection of pancreatic glucagon (400 micrograms/kg) at dark onset also reduced food intake in 24-h ...

journal_title：Peptides

authors： Lutz TA,Del Prete E,Szabady MM,Scharrer E

更新日期：1996-01-01 00:00:00

abstract：:To further characterize the structure and function of calcitonin gene-related peptide (CGRP) related peptides in fish, we have cloned cDNA sequences for CGRP, amylin, adrenomedullin (AM) and adrenomedullin-2/intermedin (IMD) in goldfish (Carassius auratus) and examined their tissue distribution. CGRP, amylin, AM and I...

journal_title：Peptides

authors： Martínez-Alvarez RM,Volkoff H,Cueto JA,Delgado MJ

更新日期：2008-09-01 00:00:00

abstract：:LL-37 is the single cathelicidin host defense peptide in humans with direct antimicrobial and immunomodulatory activities. Specific regulation of LL-37 synthesis has emerged as a novel non-antibiotic approach to disease control and prevention. Short-chain fatty acids, and butyrate in particular, were found recently to...

journal_title：Peptides

authors： Jiang W,Sunkara LT,Zeng X,Deng Z,Myers SM,Zhang G

更新日期：2013-12-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...

journal_title：Peptides

authors： Improta G,Broccardo M

更新日期：1988-07-01 00:00:00

abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...

journal_title：Peptides

authors： Kato J

更新日期：2020-10-01 00:00:00

abstract：:The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...

journal_title：Peptides

authors： Muñoz M,González-Ortega A,Rosso M,Robles-Frias MJ,Carranza A,Salinas-Martín MV,Coveñas R

更新日期：2012-12-01 00:00:00

abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...

journal_title：Peptides

authors： Chansela P,Goto-Inoue N,Zaima N,Sroyraya M,Sobhon P,Setou M

更新日期：2012-03-01 00:00:00

abstract：:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...

journal_title：Peptides

authors： Britz FC,Deitmer JW

更新日期：2002-12-01 00:00:00

abstract：:We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...

journal_title：Peptides

authors： Mosher JT,Birkemo LS,Johnson MF,Ervin GN

更新日期：1998-01-01 00:00:00

abstract：:Cocaine- and amphetamine regulated transcript (CART) is a recently discovered anorexigenic peptide, widely expressed in the central nervous system. Included among presumed hypothalamic mediated functions of CART are inhibition of food intake, stimulation of energy expenditure and regulation of hypothalamic-pituitary a...

journal_title：Peptides

authors： Fekete C,Lechan RM

更新日期：2006-08-01 00:00:00

abstract：:The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive...

journal_title：Peptides

authors： Mouri T,Takahashi K,Kawauchi H,Sone M,Totsune K,Murakami O,Itoi K,Ohneda M,Sasano H,Sasano N

更新日期：1993-05-01 00:00:00

abstract：:The beta-casein-derived octapeptide RINKKIEK is a noncompetitive inhibitor of soybean lipoxygenase (LOX). To investigate the molecular determinants for the enzyme-peptide interaction, a peptide library containing substitutional analogs of RINKKIEK was prepared by SPOT synthesis and analyzed for interaction with fluore...

journal_title：Peptides

authors： Schurink M,van Berkel WJ,Wichers HJ,Boeriu CG

更新日期：2007-12-01 00:00:00

abstract：:Liver-expressed antimicrobial peptide 2 (LEAP-2) is a 40-residue cationic peptide originally purified from human blood ultrafiltrate. The native peptide contains two disulfide bonds and is unique regarding its primary structure. Its biological role is not known but a previous study showed that chemically synthesized L...

journal_title：Peptides

authors： Hocquellet A,Odaert B,Cabanne C,Noubhani A,Dieryck W,Joucla G,Le Senechal C,Milenkov M,Chaignepain S,Schmitter JM,Claverol S,Santarelli X,Dufourc EJ,Bonneu M,Garbay B,Costaglioli P

更新日期：2010-01-01 00:00:00

abstract：:Ghrelin is a 28 amino acid peptide, primarily produced by the oxyntic mucosa X/A like neuroendocrine cells in the stomach. It is also found in the small intestine, hypothalamus, pituitary gland, pancreas, heart, adipose tissue, and immune system. In gastrointestinal neuroendocrine tumors (NETs) ghrelin release has bee...

journal_title：Peptides

authors： Vu JP,Wang HS,Germano PM,Pisegna JR

更新日期：2011-11-01 00:00:00

abstract：:The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...

journal_title：Peptides

authors： Huhman KL,Albers HE

更新日期：1994-01-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:Exposure of guinea pigs to the elevated plus maze (X-maze), an animal model of anxiety, causes an increase of extracellular serotonin (5-HT) in the lateral prefrontal cortex monitored by microdialysis. The neuropeptide cholecystokinin (CCK) plays a role in the modulation of anxiety. To compare the roles of CCK recepto...

journal_title：Peptides

authors： Rex A,Fink H

更新日期：1998-01-01 00:00:00

abstract：:Dermorphins are potent opiate-like peptides isolated from the skin of some species of frogs. They are characterized by the presence of a D-amino acid residue, which is crucial for bioactivity. A number of analogues were prepared in order to evaluate the structure-activity relationships. The syntheses were accomplished...

journal_title：Peptides

authors： de Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F,Melchiorri P,Falconieri Erspamer G,Erspamer V,Guglietta A

更新日期：1981-10-01 00:00:00

abstract：:Metabolism of orphanin FQ/nociceptin (OFQ/N) was studied in the spinal cord of rats. The heptadecapeptide was efficiently cleaved by a neutral serine endopeptidase, thus releasing the major metabolite, OFQ/N(1-11), further truncated to the final product, OFQ/N(1-6). Biologic activity of this latter fragment was tested...

journal_title：Peptides

authors： Suder P,Kotlinska J,Smoluch MT,Sällberg M,Silberring J

更新日期：1999-01-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, originally isolated from human pheochromocytomas, and then found to be widely distributed in the various body systems. ADM derives from preproadrenomedullin, a 185-amino acid residue prohormone, containing at its N-terminal a 20-amino acid sequence, named proadrenomedulli...

journal_title：Peptides

authors： Nussdorfer GG,Rossi GP,Mazzocchi G

更新日期：1997-01-01 00:00:00

abstract：:Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...

journal_title：Peptides

authors： Ruohonen ST,Abe K,Kero M,Toukola L,Ruohonen S,Röyttä M,Koulu M,Pesonen U,Zukowska Z,Savontaus E

更新日期：2009-04-01 00:00:00

abstract：:Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...

journal_title：Peptides

authors： Postal M,Martinelli AH,Becker-Ritt AB,Ligabue-Braun R,Demartini DR,Ribeiro SF,Pasquali G,Gomes VM,Carlini CR

更新日期：2012-11-01 00:00:00

abstract：:beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...

journal_title：Peptides

authors： Yamauchi R,Wada E,Yamada D,Yoshikawa M,Wada K

更新日期：2006-12-01 00:00:00

abstract：:The aspartic protease inhibitor (ATBI) purified from a Bacillus sp. is a potent inhibitor of several proteases including recombinant HIV-1 protease, pepsin, and fungal aspartic protease. In this study, we report the cloning, and over expression of a synthetic gene coding for ATBI in Escherichia coli and establish a pu...

journal_title：Peptides

authors： Vathipadiekal V,Umasankar PK,Patole MS,Rao M

更新日期：2010-01-01 00:00:00

abstract：:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...

journal_title：Peptides

authors： Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DH

更新日期：1981-01-01 00:00:00

abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...

journal_title：Peptides

authors： Varndell IM,Tapia FJ,Probert L,Buchan AM,Gu J,De Mey J,Bloom SR,Polak JM

更新日期：1982-05-01 00:00:00

abstract：:We have used high performance liquid chromatography and radioimmunoassay to characterize the CCK-like molecules in the central nervous system. The major form of CCK is the sulfated octapeptide. This molecule is distributed unevenly among various brain regions; the highest levels are found in the cortex and striatum. W...

journal_title：Peptides

authors： Beinfeld MC,Meyer DK,Brownstein MJ

更新日期：1981-01-01 00:00:00

abstract：:We investigated basal motility and the motor effects of motilin, erythromycin, and prostigmine on segments of rabbit gastrointestinal tract removed from extrinsic neural and vascular pathway and immersed in an oxygenated organ bath. Motility was recorded by means of four strain gauges sutured on the serosal surface of...

journal_title：Peptides

authors： Marzio L,Grossi L,Martelli L,Falcucci M,Lapenna D

更新日期：1994-01-01 00:00:00

abstract：:Various growth factors and their receptors are present in the nervous system. This review focuses on the presence of epidermal growth factor (EGF) and its receptors in the central nervous system (CNS). Evidence indicates that EGF in the CNS is the result of local synthesis, by intrinsic and blood-derived macrophages, ...

journal_title：Peptides

authors： Plata-Salamán CR

更新日期：1991-05-01 00:00:00