Abstract:
:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied the cardiopulmonary responses to systemically injected enkephalins in the awake, chronically instrumented dog. In these unanesthetized dogs, Leu5-ENK, Met5-ENK, and an ENK dimer increased heart rate, systemic arterial pressure, and respiratory rate in a dose-dependent fashion. D-Phe4, Met5-ENK, an analog with behavioral activity but without analgesic or in vitro opiate effects was inactive. Leu5-ENK was studied in detail; typically, heart rate and systemic pressure increased within 20 sec and returned to baseline in less than 180 sec. Intra-arterial injections produced a smaller increase in heart rate than did intravenous injections, but similar increases in systemic arterial blood pressure were recorded. These cardiovascular responses suggest that systemically injected enkephalins suppress baroreceptor reflexes and may have a role in cardiopulmonary regulation.
journal_name
Peptidesjournal_title
Peptidesauthors
Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DHdoi
10.1016/s0196-9781(81)80095-2subject
Has Abstractpub_date
1981-01-01 00:00:00pages
403-7issue
4eissn
0196-9781issn
1873-5169pii
S0196-9781(81)80095-2journal_volume
2pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.06.016
更新日期:2014-09-01 00:00:00
abstract::In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.019
更新日期:2012-03-01 00:00:00
abstract::Peptides may act through G protein-coupled receptors to influence cardiovascular performance; thus, delineating mechanisms involved in signaling is a molecular-based strategy to influence health. Molecular switches, often represented by conserved motifs, maintain a receptor in an inactive state. However, once the swit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.07.012
更新日期:2015-09-01 00:00:00
abstract::CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90051-2
更新日期:1984-01-01 00:00:00
abstract::Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.06.004
更新日期:2003-08-01 00:00:00
abstract::Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.04.019
更新日期:2005-12-01 00:00:00
abstract::Plant sucking heteropteran bugs feed regularly on small amounts of K(+)-rich plant material, in contrast to their hematophagous relatives which imbibe large volumes of Na(+)-rich blood. It was anticipated that this would be reflected in the endocrine control of Malpighian tubule (MT) secretion. To explore this, neuroe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.09.017
更新日期:2010-03-01 00:00:00
abstract::In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00286-2
更新日期:2000-09-01 00:00:00
abstract::Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.04.027
更新日期:2006-10-01 00:00:00
abstract::In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00108-4
更新日期:1999-01-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::A method has been developed for the study of somatostatin (SS) binding to dissociated cells from rat cerebral cortex. Binding of [125I] [Tyr11]SS to cells obtained by mechanical dissociation of rat cerebral cortex was dependent on time and temperature, saturable, reversible and highly specific. Under conditions of equ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90138-u
更新日期:1990-11-01 00:00:00
abstract::Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90144-0
更新日期:1986-11-01 00:00:00
abstract::I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00182-4
更新日期:1997-01-01 00:00:00
abstract::A novel peptide, de7b, was isolated from the venom of Conus delessertii, a worm-hunting species collected in the Caribbean Sea off the Yucatan Peninsula. Its primary structure was determined by automated Edman degradation and confirmed by mass spectrometry: it contains 28 amino acids, including six Cys residues. Pepti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.12.005
更新日期:2009-03-01 00:00:00
abstract::MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00043-0
更新日期:1997-01-01 00:00:00
abstract::Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.04.026
更新日期:2006-10-01 00:00:00
abstract::The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90086-9
更新日期:1982-05-01 00:00:00
abstract::Guinea pig VIP differs from VIP of several mammals by its amino acids in positions 5, 9, 19 and 26. We tested a) its ability to occupy VIP receptors in liver and lung membranes of rat and guinea pig and in the human lymphoblastic SUP-T1 cell line and b) the ensuing adenylate cyclase stimulation. In liver and lung memb...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90180-w
更新日期:1991-01-01 00:00:00
abstract::To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00016-5
更新日期:2002-05-01 00:00:00
abstract::The pineal nonapeptide hormone arginine vasotocin (AVT) (100 ng/kg) administered intra-nasally (IN) to healthy prepubertal boys, dramatically increased the amount of REM sleep, decreased REM sleep latency, and induced REM periods at sleep onset. Neither arginine vasopressin (AVP) nor oxytocin administered IN at the do...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80113-1
更新日期:1981-10-01 00:00:00
abstract::The expression of the relaxin-3 gene, detected as a new member of the insulin superfamily using human genomic databases, is abundantly present in the brain and testis. Intracerebroventricularly (icv) administered relaxin-3 stimulates food intake. Icv administered relaxin (identical to relaxin-2 in humans) affects the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.02.020
更新日期:2010-06-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several m...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.015
更新日期:2007-09-01 00:00:00
abstract::Although physiological processes related to vascular function differ greatly between resistance arteries and conduit arteries, it is not known whether the effects of calcitonin gene-related peptide (CGRP), a vasodilator neuropeptide, on these arteries differ in humans. In the present study, the conduit portion and the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00076-9
更新日期:1996-01-01 00:00:00
abstract::Our previous findings that the degree of endotoxin-induced hypotension in the dog is inversely related to ambient temperature (19 degrees through 30 degrees C) and that only increased doses of naloxone are effective at 19 degrees C suggested that opioid activity is also influenced by ambient temperature, increasing in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90007-5
更新日期:1985-01-01 00:00:00
abstract::Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170366
更新日期:2020-10-01 00:00:00
abstract::A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.09.008
更新日期:2007-11-01 00:00:00
abstract::A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.10.026
更新日期:2012-03-01 00:00:00
abstract::Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.11.013
更新日期:2006-06-01 00:00:00
abstract::In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.008
更新日期:2005-04-01 00:00:00