Calcitonin gene-related peptide (CGRP) induces more potent vasorelaxation in the resistance portion than in the conduit portion of mesenteric arteries in humans.

abstract：:In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation. PACAP also protects cereb...

journal_title：Peptides

authors： Botia B,Basille M,Allais A,Raoult E,Falluel-Morel A,Galas L,Jolivel V,Wurtz O,Komuro H,Fournier A,Vaudry H,Burel D,Gonzalez BJ,Vaudry D

更新日期：2007-09-01 00:00:00

abstract：:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...

journal_title：Peptides

authors： Minamino N,Sudoh T,Kangawa K,Matsuo H

更新日期：1985-01-01 00:00:00

abstract：:To study structure-activity relationships of growth hormone-releasing hormone (GHRH), a competitive binding assay was developed using cloned porcine adenopituitary GHRH receptors expressed in human kidney 293 cells. Specific binding of [His1, 125I-Tyr10,Nle27]hGHRH(1-32)-NH2 increased linearly with protein concentrati...

journal_title：Peptides

authors： Hassan HA,Hsiung HM,Zhang XY,Smith DP,Smiley DL,Heiman ML

更新日期：1995-01-01 00:00:00

abstract：:Thyroglobulin (Tg) is cleaved into several peptides during thyroid hormone synthesis, an oxidative process. P40, an iodinated C-terminal peptide from human Tg, has a molecular weight of about 40 kDa and contains two hormonogenic sites. P40 is the smallest peptide that is still recognized by monoclonal antibodies from ...

journal_title：Peptides

authors： El Hassani RA,Estienne V,Blanchin S,Durand-Gorde JM,Mallet B,De Micco C,Carayon P,Lalaoui K,Ruf J

更新日期：2004-06-01 00:00:00

abstract：:This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...

journal_title：Peptides

authors： Gäde G,Simek P,Marco HG

更新日期：2009-03-01 00:00:00

abstract：:Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...

journal_title：Peptides

authors： Duque HM,Mourão CBF,Tibery DV,Barbosa EA,Campos LA,Schwartz EF

更新日期：2017-09-01 00:00:00

abstract：:The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...

journal_title：Peptides

authors： Szöke B,Horváth J,Halmos G,Rékási Z,Groot K,Nagy A,Schally AV

更新日期：1994-01-01 00:00:00

abstract：:Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...

journal_title：Peptides

authors： Day TA,Maule AG

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...

journal_title：Peptides

authors： Philipp E,Wilckens T,Friess E,Platte P,Pirke KM

更新日期：1992-01-01 00:00:00

abstract：:The conformational properties of the competitive angiotensin II antagonist sarmesin [Sar-Arg-Val-Tyr(Me)-His-Pro-Phe] and its heptapeptide analogue [des1]sarmesin in dimethylsulphoxide-d6 were investigated by nuclear Overhauser effect (NOE) enhancement studies. Assignment of all backbone and side-chain protons was pos...

journal_title：Peptides

authors： Matsoukas JM,Yamdagni R,Moore GJ

更新日期：1990-03-01 00:00:00

abstract：:Diadenosine polyphosphates (APnAs) are endogenous compounds and exert diverse cardiovascular functions. However, the effects of APnAs on atrial ANP release and contractility have not been studied. In this study, the effects of diadenosine tetraphosphate (AP4A) on atrial ANP release and contractility, and their mechani...

journal_title：Peptides

authors： Yuan K,Cao C,Bai GY,Kim SZ,Kim SH

更新日期：2007-07-01 00:00:00

abstract：:The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

journal_title：Peptides

authors： Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

更新日期：2000-09-01 00:00:00

abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

journal_title：Peptides

authors： Peters J

更新日期：2012-04-01 00:00:00

abstract：:Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear. Urotensin-related peptide (URP) is a paralog of UII in that it contains the six a...

journal_title：Peptides

authors： Prosser HC,Forster ME,Richards AM,Pemberton CJ

更新日期：2008-05-01 00:00:00

abstract：:In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...

journal_title：Peptides

authors： Bickel M,Belz U

更新日期：1988-05-01 00:00:00

abstract：:Several considerations led us to directly measure, using radioimmunoassay, the levels of dynorphin-A(1-8), cholecystokinin-8, and Met5-enkephalin-Arg6-Gly7-Leu8 (MERGL) in lysed-P2 membranes, membranes incubated 60 min at 25 degrees C in 50 mM TRIS-HCl at pH 7.4, and membranes preincubated 60 min at 25 degrees C in TR...

journal_title：Peptides

authors： Rothman RB,Danks JA,Iadarola MJ

更新日期：1987-07-01 00:00:00

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...

journal_title：Peptides

authors： Wanke IE,Huang M,Rorstad OP

更新日期：1990-11-01 00:00:00

abstract：:Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...

journal_title：Peptides

authors： Lloyd PE,Kupfermann I,Weiss KR

更新日期：1987-01-01 00:00:00

abstract：:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...

journal_title：Peptides

authors： Gehlert DR,Gackenheimer SL,Millington WR,Manning AB,Chronwall BM

更新日期：1994-01-01 00:00:00

abstract：:The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...

journal_title：Peptides

authors： Ghazal P,Corsi M,Roth A,Faggioni F,Corti C,Merlo Pick E,Pucciarelli S,Ciccocioppo R,Ubaldi M

更新日期：2014-11-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:The effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in sham-operated (Sham) and vestibular-lesioned (VL) mice were examined by in situ hybridization histochemistry. Corticotrophin-releasing hormone (CRH) in the paraventricular nucleus was increased significantly in Sham...

journal_title：Peptides

authors： Sonoda S,Yoshimura M,Abe C,Morita H,Ueno H,Motojima Y,Saito R,Maruyama T,Hashimoto H,Tanaka Y,Ueta Y

更新日期：2018-07-01 00:00:00

abstract：:Glucocorticoids have been shown to decrease CRF receptor binding in the anterior pituitary. To determine whether glucocorticoids or CRF peptide modulate CRF-R1 gene expression, CRF-R1 mRNA levels in rat pituitary and brain were measured after administration of a synthetic glucocorticoid, dexamethasone (DEX) or rat/hum...

journal_title：Peptides

authors： Zhou Y,Spangler R,LaForge KS,Maggos CE,Ho A,Kreek MJ

更新日期：1996-01-01 00:00:00

abstract：:A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...

journal_title：Peptides

authors： Anderson WG,Leprince J,Conlon JM

更新日期：2008-08-01 00:00:00

abstract：:Peptidomic analysis of norepinephrine-stimulated skin secretions of the South-East Asian frog Hylarana erythraea (formerly Rana erythraea partim) has led to the identification of multiple peptides with antimicrobial activity. Structural characterization of the peptides demonstrated that they belong to the brevinin-1 (...

journal_title：Peptides

authors： Al-Ghaferi N,Kolodziejek J,Nowotny N,Coquet L,Jouenne T,Leprince J,Vaudry H,King JD,Conlon JM

更新日期：2010-04-01 00:00:00

abstract：:The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitu...

journal_title：Peptides

authors： Feng X,Liu T,Wang F,Cao R,Zhou B,Zhang Y,Mao X,Chen P,Zhang H

更新日期：2011-06-01 00:00:00

abstract：:The influence of peripheral somatostatin immunoneutralization on intravenous (i.v.) and intracerebroventricular (ICV) bombesin-induced inhibition of gastric acid secretion (GAS) was investigated with the somatostatin monoclonal antibody, CURE.S6, in rats. The somatostatin antibody, injected i.v. in conscious rats with...

journal_title：Peptides

authors： Martínez V,Yang H,Wong HC,Walsh JH,Taché Y

更新日期：1995-01-01 00:00:00

abstract：:A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...

journal_title：Peptides

authors： Cox HM,Pollock EL,Tough IR,Herzog H

更新日期：2001-03-01 00:00:00

abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...

journal_title：Peptides

authors： Deng PY,Li YJ

更新日期：2005-09-01 00:00:00