Abstract：
:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-terminus, preceded by paired Arg residues, implicating their biosynthetic relationship. Their potent uterus stimulating activity and hypertensive effect, as well as their unique C-terminal amide structure are indicative of their specialized physiological function. In addition, by utilizing a specific radioimmunoassay for neuromedin B that is a bombesin-like peptide identified in porcine spinal cord, we have isolated two novel "big" neuromedin B, designated neuromedin B-32 and B-30, from pig brain and spinal cord, indicative of their biosynthetic relationship. Nine neuromedins (B, B-30, B-32, C, K, L, N, U-8 and U-25) thus far identified in porcine spinal cord as the smooth-muscle stimulating peptides, are classified into four families; B-(bombesin-like), K-(kassinine-like), N-(neurotensin-like) and U-groups.
journal_name
Peptidesjournal_title
Peptidesauthors
Minamino N,Sudoh T,Kangawa K,Matsuo Hdoi
10.1016/0196-9781(85)90381-xsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
245-8eissn
0196-9781issn
1873-5169pii
0196-9781(85)90381-Xjournal_volume
6 Suppl 3pub_type
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