Abstract:
:Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the receptor binding of 125I-VIP was studied using the following assays: (1) isolated synaptosomes from rat cerebral cortex, (2) crude plasma membranes from hog uterine smooth muscle, and (3) purified plasma membranes and isolated hepatocytes from hog liver. Apamin inhibited the receptor-bound 125I-VIP on membranes from brain or myometrium, although the binding affinity was 100-1000 times lower than for VIP. The displacement curves for VIP and apamin were parallel suggesting that apamin interacts with both the low and high affinity VIP receptors. In membranes and cells from liver, apamin was unable to displace receptor-bound 125I-VIP in concentrations up to 50 mumol/l. The findings suggest that the VIP receptors in liver are different from those in the brain cortex and myometrium.
journal_name
Peptidesjournal_title
Peptidesauthors
Fahrenkrug J,Gammeltoft S,Staun-Olsen P,Ottesen B,Sjöquist Adoi
10.1016/0196-9781(83)90102-xsubject
Has Abstractpub_date
1983-03-01 00:00:00pages
133-6issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(83)90102-Xjournal_volume
4pub_type
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