Abstract：
:Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats. Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats. A test of the ability of AMY to form a conditioned taste aversion yielded no change in saccharin preference, as compared to controls treated with vehicle. These results suggest that although AMY has adipsic effects, the reduction in water is not of sufficient magnitude to cause the anorexia. In addition, the failure of AMY to support a conditioned taste aversion suggests that AMY does not cause anorexia by inducing malaise. Therefore, in addition to other metabolic effects, AMY may be involved in the control of food and water intake.
journal_name
Peptidesjournal_title
Peptidesauthors
Chance WT,Balasubramaniam A,Chen X,Fischer JEdoi
10.1016/0196-9781(92)90057-asubject
Has Abstractpub_date
1992-09-01 00:00:00pages
961-4issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(92)90057-Ajournal_volume
13pub_type
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