Abstract:
:To examine the relationship between glutamate receptors and the action of NC-1900 on a step-through passive avoidance (PA) task in mice, MK-801, an NMDA receptor blocker, and (S)-4-carboxyphenylglycine (4CPG), a group I metabotropic receptor antagonist, were administered intraventricularly (i.c.v.) singly or as co-injections. The i.c.v. injection of MK-801 (0.8 microg) or 4CPG (2 microg) decreased the latency on the PA task. NC-1900 (1 ng/kg, subcutaneously (s.c.)) alone prolonged the latency on the retention trial in the PA task. MK-801 (0.2 and 0.8 microg) or 4CPG (0.5 and 2 microg) significantly inhibited the action of NC-1900, while the s.c. injection of NC-1900 did not affect latency in mice that received i.c.v. co-injection of MK-801 and 4CPG at any of the doses tested. These results suggest that glutamate receptors participate in the action of NC-1900 on learning and memory in PA task performance.
journal_name
Peptidesjournal_title
Peptidesauthors
Sato T,Ishida T,Tanaka K,Chowdhurry N,Irifune M,Hirate K,Mimura T,Nishikawa Tdoi
10.1016/j.peptides.2004.12.014subject
Has Abstractpub_date
2005-05-01 00:00:00pages
893-7issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(04)00569-8journal_volume
26pub_type
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