Abstract:
:Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainstem. In the hypothalamus, all hcrt-1 positive neuronal soma also displayed hcrt-2 immunoreactivity. In the brainstem, both hcrt-1 and hcrt-2 antibodies labeled the same fibers/terminals, indicating that hcrt-1 and hcrt-2 co-localize not only in the neuronal soma (hypothalamus) but also in their fibers/terminals (brainstem). If both peptides are released following neuronal activity, then the distinct effects of these peptides in the brain are likely to depend on the types of postsynaptic receptors that are activated.
journal_name
Peptidesjournal_title
Peptidesauthors
Zhang JH,Sampogna S,Morales FR,Chase MHdoi
10.1016/s0196-9781(02)00084-0subject
Has Abstractpub_date
2002-08-01 00:00:00pages
1479-83issue
8eissn
0196-9781issn
1873-5169pii
S0196978102000840journal_volume
23pub_type
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