Isolation and cDNA cloning of cholecystokinin from the skin of Rana nigrovittata.

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by...

journal_title：Peptides

authors： Read D,Shulkes A,Fernley R,Simpson R

更新日期：1991-07-01 00:00:00

abstract：:The role of hippocampal dynorphin A (1-8) (Dyn A (1-8)) and kappa opioid receptors was investigated in the isolation-induced hypertensive rat (IHR). Male Sprague Dawley rats were either isolated (1 per cage) or grouped (3 per cage) for 7 days. Isolated rats exhibited increased blood pressure (systolic blood pressure 1...

journal_title：Peptides

authors： Wright RC,McConnaughey MM,Ingenito AJ

更新日期：2000-12-01 00:00:00

abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...

journal_title：Peptides

authors： Ivars J,Butruille L,Knauf C,Bouckenooghe T,Mayeur S,Vieau D,Valet P,Deruelle P,Lesage J

更新日期：2012-05-01 00:00:00

abstract：:Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. One of the major goals of the current cardiovascular research is to identify a reliable cardioprotective intervention that can salvage ischemic myocardium. The ...

journal_title：Peptides

authors： Alizadeh AM,Faghihi M,Sadeghipour HR,Mohammadghasemi F,Imani A,Houshmand F,Khori V

更新日期：2010-07-01 00:00:00

abstract：:Obesity is a chronic inflammatory disease significantly risen worldwide, especially among children. Adipokines, secreted from adipose tissue, are hormones involved in various cellular processes such as energy metabolism and inflammation. Among the others, adiponectin is gaining increasing interest for its insulin-sent...

journal_title：Peptides

authors： Nigro E,Piombino P,Scudiero O,Monaco ML,Schettino P,Chambery A,Daniele A

更新日期：2015-01-01 00:00:00

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9 kDa was isolated from fresh fruiting bodies of the mushroom Agrocybe cylindracea. The isolation procedure comprised ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography by fast protein liquid chromatogr...

journal_title：Peptides

authors： Ngai PH,Zhao Z,Ng TB

更新日期：2005-02-01 00:00:00

abstract：:The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...

journal_title：Peptides

authors： Currie PJ,Coscina DV

更新日期：1995-01-01 00:00:00

abstract：:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of...

journal_title：Peptides

authors： Nagoshi Y,Kuwasako K,Cao YN,Imamura T,Kitamura K,Eto T

更新日期：2004-07-01 00:00:00

abstract：:Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...

journal_title：Peptides

authors： Bernardes CP,Santos NAG,Sisti FM,Ferreira RS,Santos-Filho NA,Cintra ACO,Cilli EM,Sampaio SV,Santos AC

更新日期：2018-06-01 00:00:00

abstract：:Liver-expressed antimicrobial peptide 2 (LEAP-2) is a 40-residue cationic peptide originally purified from human blood ultrafiltrate. The native peptide contains two disulfide bonds and is unique regarding its primary structure. Its biological role is not known but a previous study showed that chemically synthesized L...

journal_title：Peptides

authors： Hocquellet A,Odaert B,Cabanne C,Noubhani A,Dieryck W,Joucla G,Le Senechal C,Milenkov M,Chaignepain S,Schmitter JM,Claverol S,Santarelli X,Dufourc EJ,Bonneu M,Garbay B,Costaglioli P

更新日期：2010-01-01 00:00:00

abstract：:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...

journal_title：Peptides

authors： Cao G,Beinfeld MC

更新日期：1992-11-01 00:00:00

abstract：:Pinealectomized (PX) and sham animals were administered either AVT (1 ng/kg) or vehicle (1 ml H20). Boxing-kicking-biting episodes were significantly reduced by administration of AVT, F(1,21) = 8.09, p less than 0.009. Crawling under behavior was increased in PXH20 animals (p less than 0.05). Non-aggressive rearing wa...

journal_title：Peptides

authors： Brown R,King MG

更新日期：1984-11-01 00:00:00

abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...

journal_title：Peptides

authors： Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

更新日期：1991-11-01 00:00:00

abstract：:Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...

journal_title：Peptides

authors： Hikosaka T,Tsuruda T,Nagata S,Kuwasako K,Tsuchiya K,Hoshiko S,Inatsu H,Chijiiwa K,Kitamura K

更新日期：2011-09-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells transition to a mesenchymal phenotype, has been implicated in the pathogenesis of renal fibrosis. Apelin, a bioactive peptide, has recently been recognized to protect against renal profibrotic activity, but the underlyi...

journal_title：Peptides

authors： Wang LY,Diao ZL,Zheng JF,Wu YR,Zhang QD,Liu WH

更新日期：2017-10-01 00:00:00

abstract：:The typical cardiovascular response to polymicrobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase. Although the factors and/or mediators responsible for producing the transition from the hyperdynamic to the hypodynamic stage are not fully understood, recent studies have...

journal_title：Peptides

authors： Wang P

更新日期：2001-11-01 00:00:00

abstract：:Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membran...

journal_title：Peptides

authors： Almaaytah A,Albalas Q

更新日期：2014-01-01 00:00:00

abstract：:The influence of peripheral somatostatin immunoneutralization on intravenous (i.v.) and intracerebroventricular (ICV) bombesin-induced inhibition of gastric acid secretion (GAS) was investigated with the somatostatin monoclonal antibody, CURE.S6, in rats. The somatostatin antibody, injected i.v. in conscious rats with...

journal_title：Peptides

authors： Martínez V,Yang H,Wong HC,Walsh JH,Taché Y

更新日期：1995-01-01 00:00:00

abstract：:Urotensin-II (U-II), a cyclic peptide widely expressed in blood vessels, has diverse vascular actions that range from potent vasoconstriction to vasodilation. Although, U-II-induced vasodilation has been shown to be partially dependent on nitric oxide (NO), the involvement of vascular adventitia-derived NO, remains un...

journal_title：Peptides

authors： Lin L,Ding WH,Jiang W,Zhang YG,Qi YF,Yuan WJ,Tang CS

更新日期：2004-11-01 00:00:00

abstract：:Pituitary cells from 14-day-old rats were separated by unit gravity velocity sedimentation, and a highly enriched population of gonadotrophs was established in reaggregate cell culture in serum-free and serum albumin-free defined culture media. The medium conditioned by these aggregates was concentrated, ultrafiltrate...

journal_title：Peptides

authors： Tilemans D,Jacobs GF,Andries M,Proost P,Devreese B,Van Damme J,Van Beeumen J,Denef C

更新日期：1994-01-01 00:00:00

abstract：:Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-ope...

journal_title：Peptides

authors： Liu B,Zhang B,Roos CM,Zeng W,Zhang H,Guo R

更新日期：2020-11-01 00:00:00

abstract：:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...

journal_title：Peptides

authors： Gafvelin G

更新日期：1990-07-01 00:00:00

abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...

journal_title：Peptides

authors： Micanovic R,Kruggel W,Ray P,Lewis RV

更新日期：1984-09-01 00:00:00

abstract：:NLP-12a and b have been identified as cholecystokinin/sulfakinin-like neuropeptides in the free-living nematode Caenorhabditis elegans. They are suggested to play an important role in the regulation of digestive enzyme secretion and fat storage. This study reports on the identification and characterization of an NLP-1...

journal_title：Peptides

authors： Peeters L,Janssen T,De Haes W,Beets I,Meelkop E,Grant W,Schoofs L

更新日期：2012-03-01 00:00:00

abstract：:Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...

journal_title：Peptides

authors： Rottkamp CA,Atwood CS,Joseph JA,Nunomura A,Perry G,Smith MA

更新日期：2002-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...

journal_title：Peptides

authors： Aldegunde M,Mancebo M

更新日期：2006-04-01 00:00:00

abstract：:Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...

journal_title：Peptides

authors： Rotondo A,Amato A,Lentini L,Baldassano S,Mulè F

更新日期：2011-01-01 00:00:00