Abstract：
:Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. One of the major goals of the current cardiovascular research is to identify a reliable cardioprotective intervention that can salvage ischemic myocardium. The aim of the present study is to evaluate the oxytocin (OT)-induced cardioprotection and the signaling pathway involved with mitochondrial ATP-dependent potassium (mitoKATP) channel in the anesthetized rat heart. Animals were divided into six groups (n=6): (1) IR; hearts were subjected to 25 min ischemia and 120 min reperfusion, (2) OT; oxytocin was administered (0.03 microg/kg i.p.) 25 min prior to ischemia, (3) ATO+OT; atosiban (ATO) was used as an OT-selective receptor antagonist (1.5 microg/kg i.p.) 10 min prior to OT administration, (4) ATO; atosiban was used 35 min prior to ischemia, (5) 5HD+OT; 5-hydroxydecanoic acid (5HD) was used as a specific inhibitor of mitoKATP channel (10mg/kg i.v.) 10 min prior to OT administration, (6) 5HD; 5HD was used 35min prior to ischemia. Then infarct size, ventricular arrhythmia and creatine kinase-MB isoenzyme (CK-MB) plasma level were measured. Hemodynamic parameters were recorded throughout the experiment. OT administration significantly decreased infarct size, CK-MB plasma level, severity and incidence of ventricular arrhythmia as compared to IR group. Administration of atosiban and 5HD abolished the cardiopreconditioning effect of OT. This study demonstrates that cardioprotective effects of OT are mediated through opening the mitoKATP channels.
journal_name
Peptidesjournal_title
Peptidesauthors
Alizadeh AM,Faghihi M,Sadeghipour HR,Mohammadghasemi F,Imani A,Houshmand F,Khori Vdoi
10.1016/j.peptides.2010.04.012subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1341-5issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00166-Xjournal_volume
31pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:The cervical sympathetic trunk-submandibular gland neuroendocrine axis plays an integral role in physiological adaptations and contributes to the maintenance of systemic homeostasis, particularly under the 'stress conditions' seen with tissue damage, inflammation, and aggressive behavior. The variety of polypeptides, ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(00)00158-3
更新日期：2000-03-01 00:00:00
abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90116-0
更新日期：1985-05-01 00:00:00
abstract：:alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80026-5
更新日期：1981-07-01 00:00:00
abstract：:Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.06.014
更新日期：2007-01-01 00:00:00
abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.01.017
更新日期：2008-06-01 00:00:00
abstract：:beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.009
更新日期：2006-12-01 00:00:00
abstract：:The brain and the retrocerebral complex of the locust, Locusta migratoria, were examined for the presence of FMRFamide-related peptides (FaRPs) using an RIA specific for -RFamide. RP-HPLC of these extracts using both C18 and phenyl columns revealed the presence of several FaRPs eluting at different percentages of acet...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90193-7
更新日期：1994-01-01 00:00:00
abstract：:Antibodies to the extreme C-terminal pentapeptide of procholecystokinin, YEYPS (in the single letter notation), have been used in radioimmunoassay and immunohistochemistry to characterize the material in rat intestine. There is a single major immunoreactive peptide in intestinal extracts that has the properties of the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90170-7
更新日期：1987-01-01 00:00:00
abstract：:125I-Ang I binding to atypical sites on Mycoplasma hyorhinis-contaminated IEC-18 cell membranes increased with increasing pH and [NaCl] (ED50 at 500 mM; maximal 13-fold increase at 2 M NaCl). Alkali metal chlorides and sodium halides increased binding with rank orders of Na+ < K+ < Rb+ < Cs+ = Li+ and F- < Cl- < Br < ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00163-6
更新日期：1999-01-01 00:00:00
abstract：:Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00581-2
更新日期：2002-01-01 00:00:00
abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90105-0
更新日期：1984-09-01 00:00:00
abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90117-7
更新日期：1984-09-01 00:00:00
abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.014
更新日期：2013-10-01 00:00:00
abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90005-3
更新日期：1989-11-01 00:00:00
abstract：:Adrenocorticotropic Hormone (ACTH), Melanocyte-Stimulating Hormone (MSH), and related peptides have been shown to have several neurogenic effects: alteration of cerebral protein synthesis, RNA synthesis, protein phosphorylation, and neurotransmitter turnover. Furthermore, there appears to be an ACTH containing circuit...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90101-2
更新日期：1982-05-01 00:00:00
abstract：:Motilin is a regulatory polypeptide of 22 amino acid residues and orginates in motilin cells scattered in the duodenal epithelium of most mammals and chickens. Motilin is released into the general circulation at about 100-min intervals during the interdigestive state and is the most important factor in controlling the...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(96)00333-6
更新日期：1997-01-01 00:00:00
abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.04.016
更新日期：2012-07-01 00:00:00
abstract：:Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.12.018
更新日期：2005-05-01 00:00:00
abstract：:Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00183-7
更新日期：2000-01-01 00:00:00
abstract：:This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.07.022
更新日期：2009-03-01 00:00:00
abstract：:Evidence on the relative roles of endothelin ET(A) and ET(B) receptors in mediating the nociceptive and hyperalgesic actions of endothelin-1 is still fragmented and conflicting, due to variations between species and/or models. This study assesses the participation of ET(A) and ET(B) receptors on the nociceptive behavi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.011
更新日期：2009-05-01 00:00:00
abstract：:The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.05.029
更新日期：2011-08-01 00:00:00
abstract：:The effect of caseinomacropeptide (CMP) (the [106-169] fragment of kappa-casein produced during digestion of milk protein), was studied in anesthetized rats using bile diversion for a pure pancreatic juice collection system. Intraduodenal administration of CMP induced a dose-related specific stimulation of pancreatic ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00307-7
更新日期：2000-10-01 00:00:00
abstract：:We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.03.009
更新日期：2014-06-01 00:00:00
abstract：:Although physiological processes related to vascular function differ greatly between resistance arteries and conduit arteries, it is not known whether the effects of calcitonin gene-related peptide (CGRP), a vasodilator neuropeptide, on these arteries differ in humans. In the present study, the conduit portion and the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00076-9
更新日期：1996-01-01 00:00:00
abstract：:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00378-8
更新日期：2001-02-01 00:00:00
abstract：:Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.10.023
更新日期：2011-02-01 00:00:00
abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90011-q
更新日期：1992-11-01 00:00:00
abstract：:The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90052-3
更新日期：1982-03-01 00:00:00
