Abstract:
:The brain and the retrocerebral complex of the locust, Locusta migratoria, were examined for the presence of FMRFamide-related peptides (FaRPs) using an RIA specific for -RFamide. RP-HPLC of these extracts using both C18 and phenyl columns revealed the presence of several FaRPs eluting at different percentages of acetonitrile. The sequences of two peptides were determined. One sequence is identical to the previously described SchistoFLRFamide (PDVDHVFLRFamide), whereas a second peptide is novel and differs from SchistoFLRFamide in positions 1 and 4 (ADVGHVFLRFamide). The bioactivity of these native and synthetic FaRPs on locust oviduct contractions has been examined. Both peptides showed inhibitory activity on the locust oviduct. Truncated versions of PDVDHVFLRFamide revealed that the essential features for inhibition lay in the sequence HVFLRFamide.
journal_name
Peptidesjournal_title
Peptidesauthors
Peeff NM,Orchard I,Lange ABdoi
10.1016/0196-9781(94)90193-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
387-92issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(94)90193-7journal_volume
15pub_type
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