Abstract：
:A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expressed in atria. We now report that ANF mRNA is present in ventricular tissue as well as in atria. This is clearly demonstrated by in situ hybridization and by Northern blot analysis. Rat ventricular ANF mRNA concentration is a hundred-fold lower than in atria. As in atria, the 126 amino acids precursor form of ANF is predominant in ventricles and it is present at a thousand-fold lower concentration. The ten-fold discrepancy in the ratio of ANF mRNA to immunoreactivity between atria and ventricles could reflect a higher rate of peptide release in the latter. Thus, ventricular ANF production may be physiologically significant in view of the much larger ventricular mass.
journal_name
Peptidesjournal_title
Peptidesauthors
Nemer M,Lavigne JP,Drouin J,Thibault G,Gannon M,Antakly Tdoi
10.1016/0196-9781(86)90145-2subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1147-52issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(86)90145-2journal_volume
7pub_type
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