Abstract:
:Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interaction with sympathetic nervous system (SNS). However, whether peripheral NPY has a direct effect on induction of the Uncoupling protein1 (UCP1)-positive adipocytes is unknown. We have used adipocytes derived from C3H10T1/2 stem cells as a model of brown-like adipocyte, and investigated the role of NPY in their differentiation and activation. In general, NPY had no effect on brown adipogenesis of C3H10T1/2 stem cell, but suppressed db-cAMP activation of brown-like adipocytes, which was due to blunting brown fat-relevant gene expression and mitochondrial function. NPY showed suppression in a receptor-dependent manner, inhibition of endogenous cAMP production and cAMP-PKA-dependent pathways p38 MAPK and CREB phosphorylation were involved in the downstream mechanisms. A novel role of NPY in the peripheral is presented, which may help decrease energy expenditure in WAT of obese subjects.
journal_name
Peptidesjournal_title
Peptidesauthors
Wan Y,Xue R,Wang Y,Zhang Q,Huang S,Wu W,Ye H,Zhang Z,Li Ydoi
10.1016/j.peptides.2014.10.018subject
Has Abstractpub_date
2015-01-01 00:00:00pages
126-33eissn
0196-9781issn
1873-5169pii
S0196-9781(14)00325-8journal_volume
63pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90102-x
更新日期:1983-03-01 00:00:00
abstract::Defense peptides play a crucial role in insect innate immunity against invading pathogens. From the hemolymph of immune-challenged greater wax moth, Galleria mellonella (Gm) larvae, eight peptides were isolated and characterized. Purified Gm peptides differ considerably in amino acid sequences, isoelectric point value...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.11.010
更新日期:2007-03-01 00:00:00
abstract::Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00021-6
更新日期:1996-01-01 00:00:00
abstract::The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.007
更新日期:2013-05-01 00:00:00
abstract::Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90131-3
更新日期:1988-07-01 00:00:00
abstract::Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.008
更新日期:2012-09-01 00:00:00
abstract::A retrograde facilitation has been demonstrated in the one trial step-down inhibitory avoidance of melanin-concentrating hormone (MCH), when it was infused into rat hippocampal formation. Considering the high density of specific binding sites for the MCH peptide on the hippocampus and the participation of this structu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00591-5
更新日期:2002-01-01 00:00:00
abstract::To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its mu-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro(6)]DM) and analyzed the c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00057-3
更新日期:2003-03-01 00:00:00
abstract::Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.014
更新日期:2011-01-01 00:00:00
abstract::The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90014-3
更新日期:1987-05-01 00:00:00
abstract::The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90087-2
更新日期:1986-09-01 00:00:00
abstract::The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00254-0
更新日期:2000-08-01 00:00:00
abstract::Medium conditioned by a highly enriched population of gonadotrophs, cultured as reaggregates in the presence of 0.01 nM GnRH, was concentrated, separated on a reversed-phase HPLC column, and tested for activity on lactotroph development in pituitary reaggregate cell cultures of 14-day-old rats. The number of cells exp...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00175-1
更新日期:1996-01-01 00:00:00
abstract::We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.04.001
更新日期:2016-05-01 00:00:00
abstract::Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.12.006
更新日期:2012-01-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.019
更新日期:2009-09-01 00:00:00
abstract::We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00379-5
更新日期:2001-04-01 00:00:00
abstract::The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00109-8
更新日期:2003-04-01 00:00:00
abstract::A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90153-2
更新日期:1988-05-01 00:00:00
abstract::A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known proteins and peptides and a molecular mass of 8kDa, was isolated from seeds of the green chickpea Cicer arietinum cv green chickpea. Cicerarin was isolated with a procedure that involved ion exchange chrom...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00134-7
更新日期:2003-05-01 00:00:00
abstract::Female Sprague-Dawley rat pups were injected SC with either ACTH(1-24) (0.5 mg/kg) or saline vehicle once daily from postnatal day 1 (day of birth) to day 7. Plasma corticosterone (CORT) levels were recorded via radioimmunoassay (RIA) on day 4 to measure adrenal response to these treatments. Hypothalamic 5-HT and DA f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90056-m
更新日期:1993-03-01 00:00:00
abstract::Incorporation of N-succinimidyl-3(4-hydroxyphenyl) propionate (Bolton-Hunter reagent) or its 125I-labeled derivative into peptides can be selectively directed towards either alpha- or epsilon-amine functions by modifying the pH of the reaction. Acylation of alpha-amino groups is favored at pH 6.5 whereas epsilon-amino...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90027-z
更新日期:1992-11-01 00:00:00
abstract::Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170195
更新日期:2020-01-01 00:00:00
abstract::As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.06.008
更新日期:2017-08-01 00:00:00
abstract::The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00150-5
更新日期:1995-01-01 00:00:00
abstract::Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00194-1
更新日期:2000-02-01 00:00:00
abstract::As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90046-2
更新日期:1981-01-01 00:00:00
abstract::Three analogs of Mast Cell Degranulating (MCD) peptide with C-terminal and one analog with N- and C-terminal deletions were synthesized and assayed for histamine-releasing activity in mast cells. Des(20-22)-MCD and des(21)-MCD markedly decreased this activity. In des(16-17,21)-MCD this activity was completely abolishe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00253-2
更新日期:1998-01-01 00:00:00
abstract::The acute behavioral effects of some neurohypophyseal hormones after intracerebroventricular injection in mice were examined. The effects, consisting mainly of a dose-dependent stimulation of certain behaviors, were demonstrated in three different behavioral tests. The type of the induced behaviors was dependent on th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80003-4
更新日期:1981-04-01 00:00:00
abstract::The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum diluti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90047-7
更新日期:1994-01-01 00:00:00