Abstract：
:Three analogs of Mast Cell Degranulating (MCD) peptide with C-terminal and one analog with N- and C-terminal deletions were synthesized and assayed for histamine-releasing activity in mast cells. Des(20-22)-MCD and des(21)-MCD markedly decreased this activity. In des(16-17,21)-MCD this activity was completely abolished. By contrast, when the C- and N-termini were truncated in des(1-2,20-22)-MCD, the full activity of MCD peptide was restored. The possibility that these analogs trigger or inhibit oxygen radicals from neutrophils was examined in a cell-free system with a chemiluminescence assay. None of the above analogs exhibited inflammatory or anti-inflammatory activity. Changes in biological activities were correlated with structural changes, as seen by circular dichroism (CD) spectroscopy.
journal_name
Peptidesjournal_title
Peptidesauthors
Buku A,Maulik G,Hook WAdoi
10.1016/s0196-9781(97)00253-2subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1-5issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00253-2journal_volume
19pub_type
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