Abstract:
:The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in the submucosa and only small amounts in the mucosa. The results are consistent with a neuronal location of this peptide in the human gut. Over 65% of total immunoreactivity coeluted with the authentic peptide in both molecular exclusion chromatography and HPLC, while most of the remainder activity eluted earlier on gel filtration. The latter material probably represents N-terminally extended Met5-enkephalin-Arg6-Gly7-Leu8. Taken together with previous studies, our results appear to indicate that there are important species differences in post-translational processing of proenkephalin A in gut nerves.
journal_name
Peptidesjournal_title
Peptidesauthors
Ferri GL,Morreale RA,Dockray GJdoi
10.1016/0196-9781(86)90087-2subject
Has Abstractpub_date
1986-09-01 00:00:00pages
735-9issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(86)90087-2journal_volume
7pub_type
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