Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury.

abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...

journal_title：Peptides

authors： Chang CL,Roh J,Hsu SY

更新日期：2004-10-01 00:00:00

abstract：:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by...

journal_title：Peptides

authors： Read D,Shulkes A,Fernley R,Simpson R

更新日期：1991-07-01 00:00:00

abstract：:The very first step in the study of the endocrine control of insect molting was taken in 1922. Stefan Kopec characterized a factor in the brain of the gypsy moth, Lymantria dispar which appeared to be essential for metamorphosis. This factor was later identified as the neuropeptide prothoracicotropic hormone (PTTH), t...

journal_title：Peptides

authors： Marchal E,Vandersmissen HP,Badisco L,Van de Velde S,Verlinden H,Iga M,Van Wielendaele P,Huybrechts R,Simonet G,Smagghe G,Vanden Broeck J

更新日期：2010-03-01 00:00:00

abstract：:Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...

journal_title：Peptides

authors： Singh RG,Nguyen NN,Cervantes A,Kim JU,Stuart CE,Petrov MS

更新日期：2019-09-01 00:00:00

abstract：:The synthesis, purification, and characterization of biotinylated analogues of motilin are reported. The C-terminal of canine motilin was extended by the addition of a cysteine residue, and then biotinylated. Biotinyl motilin was purified by following HPLC and characterized by amino acid analysis. Biotinylation of the...

journal_title：Peptides

authors： Sakai T,Satoh M,Hayashi H,Fujikura K,Sano I,Koyama H,Tatemoto K,Itoh Z

更新日期：1994-01-01 00:00:00

abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...

journal_title：Peptides

authors： Iwata T,Hardee E,Frohlich ED,Cole FE

更新日期：1989-05-01 00:00:00

abstract：:Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...

journal_title：Peptides

authors： Hoare SR,Sullivan SK,Pahuja A,Ling N,Crowe PD,Grigoriadis DE

更新日期：2003-12-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...

journal_title：Peptides

authors： Evangelou A,Zikos C,Benaki D,Pelecanou M,Bouziotis P,Papadopoulos M,Borovickova L,Vesela I,Elbert T,Kunesová G,Pirmettis I,Paravatou-Petsotas M,Slaninová J,Livaniou E

更新日期：2009-12-01 00:00:00

abstract：:Intraperitoneal (i.p.) administration of the synthetic agonist of the glucagon like peptide-1 (GLP-1) receptor exenatide reduces food intake. Here, we evaluated possible peripheral pathways for this reduction. Exenatide (0.5 μg/kg, i.p.) was given to three, overnight food-deprived, groups of rats: total subdiaphragmat...

journal_title：Peptides

authors： Hunt JV,Washington MC,Sayegh AI

更新日期：2012-02-01 00:00:00

abstract：:Peptic digestion of bovine hemoglobin at low degree of hydrolysis yields an intermediate peptide fraction exhibiting antibacterial activity against Micrococcus luteus A270, Listeria innocua, Escherichia coli and Salmonella enteritidis after separation by reversed-phase HPLC. From this fraction a pure peptide was isola...

journal_title：Peptides

authors： Daoud R,Dubois V,Bors-Dodita L,Nedjar-Arroume N,Krier F,Chihib NE,Mary P,Kouach M,Briand G,Guillochon D

更新日期：2005-05-01 00:00:00

abstract：:The effects of adrenomedullin (ADM) on C6 glioma cells were investigated. [125I]ADM bound with high affinity (Kd = 24 nM) to a single class of sites (Bmax = 36,000/cell) in C6 cells. Specific [125I]ADM binding was inhibited with high affinity by ADM (IC50 value of 10 nM) but not ADM(22-52) or pro-adrenomedullin N-term...

journal_title：Peptides

authors： Moody TW,Miller MJ,Mártinez A,Unsworth E,Cuttitta F

更新日期：1997-01-01 00:00:00

abstract：:The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...

journal_title：Peptides

authors： Ghazal P,Corsi M,Roth A,Faggioni F,Corti C,Merlo Pick E,Pucciarelli S,Ciccocioppo R,Ubaldi M

更新日期：2014-11-01 00:00:00

abstract：:Previously, we described a gene, flp-1, that encodes seven FMRFamide-like peptides from two alternatively spliced transcripts in the nematode Caenorhabditis elegans. To determine whether all or a subset of the predicted peptides coded for by flp-1 are produced in vivo, we undertook the isolation of FMRFamide-like pept...

journal_title：Peptides

authors： Rosoff ML,Doble KE,Price DA,Li C

更新日期：1993-03-01 00:00:00

abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...

journal_title：Peptides

authors： Palm S,Roman E,Nylander I

更新日期：2012-07-01 00:00:00

abstract：:Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...

journal_title：Peptides

authors： Schalla M,Prinz P,Friedrich T,Scharner S,Kobelt P,Goebel-Stengel M,Rose M,Stengel A

更新日期：2017-10-01 00:00:00

abstract：:Urocortin (Ucn) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related peptides recently characterized in mammals. Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands. They also have a distinct pattern of distribution, both in the ...

journal_title：Peptides

authors： Martinez V,Wang L,Million M,Rivier J,Taché Y

更新日期：2004-10-01 00:00:00

abstract：:[3H]Neurotensin (NT) was found to bind specifically and with high affinity to crude membranes prepared from rat uterus. Scatchard analysis of saturation binding studies indicated that [3H]NT apparently binds to two sites (high affinity Kd 0.5 nM; low affinity Kd 9 nM) with the density of high affinity sites (41 fmoles...

journal_title：Peptides

authors： Pettibone DJ,Totaro JA

更新日期：1987-11-01 00:00:00

abstract：:Intrahypothalamic injection of amylin (AMY) was shown to reduce the intake of rat chow and water for 8 and 4 h, respectively, in schedule-fed rats. Amylin also reduced water intake to a much lesser degree in 24-h water-deprived rats. A test of the ability of AMY to form a conditioned taste aversion yielded no change i...

journal_title：Peptides

authors： Chance WT,Balasubramaniam A,Chen X,Fischer JE

更新日期：1992-09-01 00:00:00

abstract：:Besides its well known endocrinological effects, thyrotropin-releasing hormone (TRH) has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders. The aim of this study was to assess if transdermal delivery of TRH and its analogue, M-TRH, in the presence of enhancers, i...

journal_title：Peptides

authors： Magnusson BM,Koskinen LO,Koch M,Karlsson K

更新日期：2001-01-01 00:00:00

abstract：:Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...

journal_title：Peptides

authors： Wang M,Rong M,Xiao Y,Liang S

更新日期：2012-03-01 00:00:00

abstract：:Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...

journal_title：Peptides

authors： Mori K,Kim J,Sasaki K

更新日期：2011-02-01 00:00:00

abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

journal_title：Peptides

authors： Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

更新日期：2018-09-01 00:00:00

abstract：:Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...

journal_title：Peptides

authors： Dillen S,Verdonck R,Zels S,Van Wielendaele P,Vanden Broeck J

更新日期：2014-03-01 00:00:00

abstract：:Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...

journal_title：Peptides

authors： Rotondo A,Amato A,Lentini L,Baldassano S,Mulè F

更新日期：2011-01-01 00:00:00

abstract：:CGRP has potent cardiovascular effects but its role in heart failure is unclear. Effects of CGRP on calcium concentrations in fresh adult rat cardiomyocytes, cultured adult cardiomyocytes and neonatal cardiomyocytes were determined by real time fluorescence spectrophotometry. Treatment of cultured adult cardiomyocytes...

journal_title：Peptides

authors： Schiess MC,Poindexter BJ,Brown BS,Bick RJ

更新日期：2005-03-01 00:00:00

abstract：:Various growth factors and their receptors are present in the nervous system. This review focuses on the presence of epidermal growth factor (EGF) and its receptors in the central nervous system (CNS). Evidence indicates that EGF in the CNS is the result of local synthesis, by intrinsic and blood-derived macrophages, ...

journal_title：Peptides

authors： Plata-Salamán CR

更新日期：1991-05-01 00:00:00

abstract：:HPLC characterization of tilapia pituitary endorphins using an antibody specific for N-terminally acetylated endorphins yielded three major peaks in the neurointermediate lobe, but none in the pars distalis. The melanotropes secreted two of the immunoreactive products in vitro, one of which coeluted with Xenopus laevi...

journal_title：Peptides

authors： Balm PH,Hovens ML,Wendelaar Bonga SE

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...

journal_title：Peptides

authors： Tanaka M,Tomimatsu Y,Sakimura K,Ootani Y,Sako Y,Kojima T,Aso K,Yano T,Hirai K

更新日期：2017-09-01 00:00:00

abstract：:Amylin and the structurally and functionally related peptide calcitonin gene-related peptide (CGRP) have been shown to reduce food intake in rats. The aim of the present study was to compare the anorectic potency of both peptides over a wide dose range when administered into the lateral brain ventricle (ICV). Furtherm...

journal_title：Peptides

authors： Lutz TA,Rossi R,Althaus J,Del Prete E,Scharrer E

更新日期：1998-01-01 00:00:00