当前位置： SCI文献检索 > PEPTIDES期刊下所有文献 > Intermedin, a novel calcitonin family peptide that exists in teleosts as well as in mammals: a comparison with other calcitonin/intermedin family peptides in vertebrates.

Intermedin, a novel calcitonin family peptide that exists in teleosts as well as in mammals: a comparison with other calcitonin/intermedin family peptides in vertebrates.

Abstract：

:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing of a variety of ligand/GPCR signaling systems. Among the ligands of type II GPCRs, the calcitonin family peptides including calcitonin, alpha-calcitonin gene-related peptide (alphaCGRP), betaCGRP, adrenomedullin, and amylin are among the best studied hormones, and the founding member, calcitonin, was originally identified and isolated from teleosts. This unique group of peptides shares a conserved tertiary structure with an N-terminal disulfide-bridged ring. In mammals, these peptides signal through two closely related type II GPCRs and three unique receptor activity-modifying proteins. Recently, based on the analysis of multiple vertebrate genomes, we identified a novel calcitonin/CGRP family peptide named intermedin. Here we show that in humans the five paralogous family genes, calcitonin, CGRP, amylin, adrenomedullin, and intermedin, evolved before the emergence of modern vertebrates, and that teleost genomes carry multiple copies of these co-evolved hormone genes. Sequence comparison showed that each of these genes is highly conserved in different vertebrates and that multiple copies of these peptides in teleosts could be derived from ancient genome duplication and/or lineage-specific intragenic duplications. The present article provides an overview of the calcitonin/intermedin family peptides found in teleost and mammalian genomes, and describes their putative functions. In addition, we demonstrate that one of the intermedin orthologs deduced from the pufferfish (Fugu rubripes) genome shares a conserved signaling activity with mammalian intermedin. The combined results indicate that the physiology associated with each of these family peptides likely evolved during early vertebrate evolution and diverged to serve select physiological functions in different vertebrates.

journal_name

Peptides

journal_title

Peptides

authors

Chang CL,Roh J,Hsu SY

doi

10.1016/j.peptides.2004.05.021

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1633-42

issue

10

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(04)00316-X

journal_volume

25

pub_type

杂志文章,评审

相关文献

PEPTIDES文献大全
  • The effect of halogenation on the antimicrobial activity, antibiofilm activity, cytotoxicity and proteolytic stability of the antimicrobial peptide Jelleine-I.

    abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2018.11.006

    authors： Jia F,Zhang Y,Wang J,Peng J,Zhao P,Zhang L,Yao H,Ni J,Wang K

    更新日期：2019-02-01 00:00:00

  • Biosynthesis of LHRH: inferences from immunocytochemical studies.

    abstract：:Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(83)90096-7

    authors： King JC,Anthony EL

    更新日期：1983-11-01 00:00:00

  • α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions.

    abstract：:Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hor...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2010.07.018

    authors： Machado I,González P,Schiöth HB,Lasaga M,Scimonelli TN

    更新日期：2010-11-01 00:00:00

  • Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway.

    abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2020.170446

    authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

    更新日期：2020-11-13 00:00:00

  • Selective effect of castration on the anterior pituitary VIP receptor of male rats.

    abstract：:We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(90)90146-v

    authors： Wanke IE,Huang M,Rorstad OP

    更新日期：1990-11-01 00:00:00

  • CART in the brain of vertebrates: circuits, functions and evolution.

    abstract：:Cocaine- and amphetamine-regulated transcript peptide (CART) with its wide distribution in the brain of mammals has been the focus of considerable research in recent years. Last two decades have witnessed a steady rise in the information on the genes that encode this neuropeptide and regulation of its transcription an...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2014.01.004

    authors： Subhedar NK,Nakhate KT,Upadhya MA,Kokare DM

    更新日期：2014-04-01 00:00:00

  • Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS.

    abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2009.03.019

    authors： Davis J,Jones A,Lewis RJ

    更新日期：2009-07-01 00:00:00

  • Characterization of endorphins from the pituitary of the spiny dogfish Squalus acanthias.

    abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(86)90071-9

    authors： Lorenz RG,Tyler AN,Faull KF,Makk G,Barchas JD,Evans CJ

    更新日期：1986-01-01 00:00:00

  • The Y1 receptor for NPY: a key modulator of the adaptive immune system.

    abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2006.09.030

    authors： Wheway J,Herzog H,Mackay F

    更新日期：2007-02-01 00:00:00

  • Significance of the N- and C-terminal regions of CAP-1, a cuticle calcification-associated peptide from the exoskeleton of the crayfish, for calcification.

    abstract：:Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2006.12.005

    authors： Inoue H,Ohira T,Nagasawa H

    更新日期：2007-03-01 00:00:00

  • Localization of neurokinin B in the central nervous system of the rat.

    abstract：:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(92)90192-6

    authors： Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JM

    更新日期：1992-07-01 00:00:00

  • Cellular colocalization of diuretic peptides in locusts: a potent control mechanism.

    abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(94)00158-3

    authors： Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

    更新日期：1995-01-01 00:00:00

  • Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6.

    abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2011.03.009

    authors： Kantyka T,Fischer J,Wu Z,Declercq W,Reiss K,Schröder JM,Meyer-Hoffert U

    更新日期：2011-06-01 00:00:00

  • Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats.

    abstract：:Herein the effect of orexin receptor type-1 antagonist SB-334867 on the development of tolerance to analgesic effects of morphine was studied in rats. To incite tolerance, morphine sulfate was injected intraperitoneally (i.p., 10mg/kg) once a day for 7 days. The tail flick test was used to evaluate antinociceptive eff...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2012.02.023

    authors： Ranjbar-Slamloo Y,Azizi H,Fathollahi Y,Semnanian S

    更新日期：2012-05-01 00:00:00

  • Change in substance P in a firearm wound and its significance.

    abstract：:The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(98)00068-0

    authors： Xinan L,Suguang L,Liangchao Z,Lei C

    更新日期：1998-01-01 00:00:00

  • Suppression of feeding by cholecystokinin but not bombesin is attenuated in dorsomedial hypothalamic nuclei lesioned rats.

    abstract：:Rats with dorsomedial hypothalamic lesions (DMN-L) or sham operations were injected IP with saline or the satiety peptide cholecystokinin (CCK) at 3.0 and 6.0 micrograms/kg at the onset of the dark phase. Food consumption was then measured 15, 30 and 60 min later. Compared to saline baseline intake, CCK suppressed fee...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(84)90085-8

    authors： Bellinger LL,Bernardis LL

    更新日期：1984-05-01 00:00:00

  • In vitro enhancement of natural cytotoxicity by atrial natriuretic peptide fragment 4-28.

    abstract：:The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(91)90145-f

    authors： Moss RB,Golightly MG

    更新日期：1991-07-01 00:00:00

  • Specific neuroanatomical and neurochemical correlates of grooming and satiety effects of bombesin.

    abstract：:Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(88)90249-5

    authors： Johnston SA,Merali Z

    更新日期：1988-01-01 00:00:00

  • High glucose promotes the release and expression of novel vasoactive peptide, coupling factor 6, in human umbilical vein endothelial cells.

    abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2006.11.006

    authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

    更新日期：2007-03-01 00:00:00

  • Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus.

    abstract：:The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(95)00020-k

    authors： Currie PJ,Coscina DV

    更新日期：1995-01-01 00:00:00

  • Characterization of [125I]beta-endorphin binding sites in the rat caudal dorsomedial medulla.

    abstract：:[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(98)00024-2

    authors： D'Souza MM,Carr JA

    更新日期：1998-01-01 00:00:00

  • Multiple antigenic peptides designed to structurally related Drosophila peptides.

    abstract：:We have isolated TDVDHVFLRFamide (DMS), FDDYGHMRFamide (DSK), and DPKQDFMRFamide from Drosophila melanogaster. These peptides, structurally related by a common C-terminus -XRFamide, where X = L or M, are encoded by three different genes. To determine cellular expression, we have generated antisera to multiple antigeni...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(96)00279-3

    authors： Nichols R,McCormick J,Lim I

    更新日期：1997-01-01 00:00:00

  • Possible mechanisms of positive inotropic action of synthetic human calcitonin gene-related peptide in isolated rat atrium.

    abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(86)90038-0

    authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

    更新日期：1986-07-01 00:00:00

  • Relationship between larval-pupal metamorphosis and transcript expression of insulin-like peptide and insulin receptor in Spodoptera littoralis.

    abstract：:Insulin-like peptides (ILPs) affect a wide variety of biological events, such as metabolism, lifespan, growth and reproduction. Two ILPs (Spoli-ILP1 and Spoli-ILP2) were identified in the cotton leafworm, Spodoptera littoralis, while the functions and developmental characters are not fully understood. In the present s...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2010.10.033

    authors： Iga M,Smagghe G

    更新日期：2011-03-01 00:00:00

  • Differential distribution of two molecular forms of gonadotropin-releasing hormone in discrete brain areas of goldfish (Carassius auratus).

    abstract：:Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay us...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(88)90174-x

    authors： Yu KL,Sherwood NM,Peter RE

    更新日期：1988-05-01 00:00:00

  • Circadian oscillations of RPCH gene expression in the eyestalk of the crayfish Cherax quadricarinatus.

    abstract：:The RPCH and beta-actin cDNAs from the crayfish Cherax quadricarinatus were amplified, cloned and sequenced. The primary structure sequences of these cDNAs were compared to other members of the AKH/RPCH family. Fluctuations in the amount of the C. quadricarinatus RPCH and beta-actin mRNAs, as cDNAs, were quantified ev...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2005.05.018

    authors： Martínez-Pérez F,Zinker S,Aguilar G,Valdés J,Aréchiga H

    更新日期：2005-12-01 00:00:00

  • Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095.

    abstract：:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2005.06.006

    authors： Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler R

    更新日期：2005-12-01 00:00:00

  • Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes.

    abstract：:Previous studies have shown that different calcitonins interact with planar lipid membranes to form ion channels. In this study, glycosylation of eel calcitonin (eCt) at different positions (Ct3-GlcNAc, Ct14-GlcNAc, Ct20-GlcNAc, Ct26-GlcNAc) is shown to preserve molecular structure and slightly change the energy of in...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2005.09.011

    authors： Meleleo D,Micelli S,Toma K,Haneda K,Gallucci E

    更新日期：2006-04-01 00:00:00

  • C-type natriuretic peptide effects on cardiovascular nitric oxide system in spontaneously hypertensive rats.

    abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2010.03.030

    authors： Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MA

    更新日期：2010-07-01 00:00:00

  • Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion.

    abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2016.01.015

    authors： Jafri L,Saleem S,Calderwood D,Gillespie A,Mirza B,Green BD

    更新日期：2016-04-01 00:00:00