Abstract:
:Amylin and the structurally and functionally related peptide calcitonin gene-related peptide (CGRP) have been shown to reduce food intake in rats. The aim of the present study was to compare the anorectic potency of both peptides over a wide dose range when administered into the lateral brain ventricle (ICV). Furthermore, we also tested the influence of a lesion in the area postrema/nucleus of the solitary tract (AP/NTS) region on the anorectic effects of amylin and CGRP after ICV administration because AP/NTS lesion has been shown to reduce the anorectic effects of both peptides when injected intraperitoneally (IP). Amylin [1-510 pmol/rat (0.004-2 microg/rat) ICV] and CGRP [1-131 pmol/rat (0.004-0.5 microg/rat) ICV] dose-dependently reduced food intake in food-deprived rats. At a dose of 26 pmol/rat (0.1 microg/rat), amylin almost completely suppressed food intake for 1 h after injection. Amylin [EC50 = 2 pmol/rat (0.007 microg/rat)] was markedly more potent than CGRP [57 pmol/rat (0.215 microg/rat)] with regard to its anorectic effect. A lesion in the AP/NTS region did not influence the anorectic effects of amylin and CGRP after administration into the lateral ventricle. It is concluded that amylin is more potent than CGRP in reducing food intake after administration into the lateral brain ventricle. Receptors in the forebrain may mediate the anorectic effects of both peptides when administered via this route.
journal_name
Peptidesjournal_title
Peptidesauthors
Lutz TA,Rossi R,Althaus J,Del Prete E,Scharrer Edoi
10.1016/s0196-9781(98)00114-4subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1533-40issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(98)00114-4journal_volume
19pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The aims of these studies were to determine the precise molecular nature of immunoreactive (IR-) vasopressin (AVP) in the ovine hypothalamo-pituitary axis and to examine a possible role for glucocorticoids in regulating both AVP processing and levels in this axis. The IR-AVP in extracts of paraventricular nucleus, med...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90119-2
更新日期:1993-07-01 00:00:00
abstract::In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00164-5
更新日期:2003-06-01 00:00:00
abstract::We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.03.015
更新日期:2006-07-01 00:00:00
abstract::Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-termina...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.015
更新日期:2006-07-01 00:00:00
abstract::Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00190-3
更新日期:1997-01-01 00:00:00
abstract::Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.08.021
更新日期:2013-11-01 00:00:00
abstract::Galanin has been shown to be present in substantial quantities in the human and rat genitourinary tract by radioimmunoassay and immunocytochemistry. The highest concentrations measured by radioimmunoassay were found in the human vas deferens, corpus cavernosum and spongiosum and in the vagina and cervix. In man gel ch...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90052-5
更新日期:1986-01-01 00:00:00
abstract::The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00068-0
更新日期:1998-01-01 00:00:00
abstract::The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential ant...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.05.022
更新日期:2006-11-01 00:00:00
abstract::Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.014
更新日期:2011-01-01 00:00:00
abstract::Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90040-2
更新日期:1983-07-01 00:00:00
abstract::Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear. Urotensin-related peptide (URP) is a paralog of UII in that it contains the six a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.013
更新日期:2008-05-01 00:00:00
abstract::Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90081-0
更新日期:1984-05-01 00:00:00
abstract::Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.018
更新日期:2014-03-01 00:00:00
abstract::The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00254-0
更新日期:2000-08-01 00:00:00
abstract::Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.002
更新日期:2013-03-01 00:00:00
abstract::Peptidomic analysis of norepinephrine-stimulated skin secretions of the South-East Asian frog Hylarana erythraea (formerly Rana erythraea partim) has led to the identification of multiple peptides with antimicrobial activity. Structural characterization of the peptides demonstrated that they belong to the brevinin-1 (...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.12.013
更新日期:2010-04-01 00:00:00
abstract::Dihydroergotoxine (DHET) is comprised of equal part of the mesylates of dihydroergocristine, dihydroergocornine and dihydroergocryptine. In the standard radioreceptor assays, DHET components displaced the CNS-receptor binding of [3H]-enkephalin (ENK) and [3H]thyrotropin releasing hormone (TRH). The inhibitory effect o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90050-0
更新日期:1984-01-01 00:00:00
abstract::Although physiological processes related to vascular function differ greatly between resistance arteries and conduit arteries, it is not known whether the effects of calcitonin gene-related peptide (CGRP), a vasodilator neuropeptide, on these arteries differ in humans. In the present study, the conduit portion and the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00076-9
更新日期:1996-01-01 00:00:00
abstract::The extractability of neurotensin (NT) from porcine ileal mucosa was studied by comparison of eight extraction procedures. Tissue content of neurotensin-like immunoreactivity was quantitated and characterized by sequence-specific radioimmunoassays and gel filtration chromatography. Homogenization prior to boiling in e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90038-6
更新日期:1987-07-01 00:00:00
abstract::An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.009
更新日期:2005-04-01 00:00:00
abstract::Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.032
更新日期:2013-03-01 00:00:00
abstract::Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00194-0
更新日期:1997-01-01 00:00:00
abstract::To study structure-activity relationships of growth hormone-releasing hormone (GHRH), a competitive binding assay was developed using cloned porcine adenopituitary GHRH receptors expressed in human kidney 293 cells. Specific binding of [His1, 125I-Tyr10,Nle27]hGHRH(1-32)-NH2 increased linearly with protein concentrati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02026-8
更新日期:1995-01-01 00:00:00
abstract::The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90161-5
更新日期:1985-07-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.009
更新日期:2013-05-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.12.007
更新日期:2016-02-01 00:00:00
abstract::Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90077-6
更新日期:1989-01-01 00:00:00