Abstract:
:Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-terminal peptide of human PTHrP. Using affinity chromatography, we applied extracts of DU 145 prostate cancer cells over PTHrP (140-173)-Sepharose and eluted with 8 M urea. After concentration and electrophoresis, protein bands were excised and subjected to mass spectroscopy analyses. Proteins identified included those associated with protection from oxidative stress, DNA repair, protection from apoptosis, and proteins involved in membrane trafficking and cytoskeletal rearrangement. These novel protein-protein interactions further support the hypothesis that the carboxy-terminus of PTHrP plays a role in cell survival.
journal_name
Peptidesjournal_title
Peptidesauthors
Grzesiak JJ,Burton DW,Deftos LJ,Bouvet Mdoi
10.1016/j.peptides.2006.01.015subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1898-901issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00064-7journal_volume
27pub_type
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