Abstract：
:Amylin can evoke insulin resistance by antagonizing insulin in a non-competitive manner. Here, we investigated the glycogenolytic effect of amylin in isolated skeletal muscle and compared it to the effects of a calcitonin gene-related peptide (CGRP). Amylin alone had no statistically significant effect on glucose transport. However, amylin decreased insulin-stimulated glucose transport by about 30%. The involvement of cAMP could not be detected at the concentrations shown to promote glycogenolysis. Previously, it has been shown that increased glycogen synthase kinase 3 (GSK3) activity plays a role in insulin resistance. Here, the ratio of GSK3 alpha:beta isoforms in rat soleus was found to be 1.2:1. We found that amylin increased GSK3alpha activity, which in turn led to increased phosphorylation of glycogen synthase and decreased glycogen synthesis de novo.
journal_name
Peptidesjournal_title
Peptidesauthors
Abaffy T,Cooper GJdoi
10.1016/j.peptides.2004.08.016subject
Has Abstractpub_date
2004-12-01 00:00:00pages
2119-25issue
12eissn
0196-9781issn
1873-5169pii
S0196-9781(04)00374-2journal_volume
25pub_type
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